Antibacterial Effect of Hypochlorous Acid Solution on Nasal Discharge from Patients with Chronic Rhinosinusitis

Abstract

Purpose The antibacterial effect of hypochlorous acid (HOCl) solution on nasal secretion of patients with chronic rhinosinusitis (CRS) was investigated. Materials and Methods Five swab specimens were collected from the middle meatus of CRS patients. The first one was placed directly in a Thanswab tube while all of the others were placed randomly into 4 glass tubes containing either HOCl solution, normal saline (NS), 75% alcohol, or povidone-iodine (PVPI) solution for one minute in the first part and for 5 minutes in the second part of the study before transfer to a Thanswab tube. Results Bacteria were cultured from 27 of 50 specimens when they were put directly in a Thanswab tube and from 26 after soaking in HOCl solution, 27 in NS, 13 in 75% alcohol, and 25 in PVPI solution for one minute. In the second part of the study, bacteria were cultured from 14 of 32 specimens when they were put directly in a Thanswab tube and from 14 after soaking in HOCl solution, 13 in NS, 3 in 75% alcohol, and 11 in PVPI solution for 5 minutes. Conclusions This study showed that HOCL solution did not exert an antibacterial effect on nasal secretion from CRS patients within 5 minutes.

Evaluation of the Effect of Different Antiseptic Solutions on Aerobic Bacterial Wound Infection

“…On the other hand, Wu et al, 11 found that there is no good antibacterial effect after soaking specimens into antiseptic solutions in general. However, this could be explained by the different methodology they applied.…”

“…8, 9 Recently, HOCl solution displayed bactericidal effects when employed as a nasal irrigant to treat pediatric chronic sinusitis. 10,11 Some disadvantages of using HOCl have been facing researchers as it was found to be highly corrosive and gradually losing its bactericidal effect with longterm preservation, therefore conditions of long-term storage and safety measures must be applied. Where the safety standard concentration within the World Health Organization for invivo use or drinking water is 5 mg/L.…”

Can the Nasal Cavity Help Tackle COVID-19?

“…Hypochlorous acid (HClO), which is known as a potent broad-spectrum antibacterial agent, has shown strong antimicrobial (antibacterial, fungicidal or virucidal) effect in nasal formulations [146,147].…”

A sprayable Acid-Oxidizing solution containing hypochlorous acid (AOS2020) efficiently and safely inactivates SARS-Cov-2: a new potential solution for upper respiratory tract hygiene

“…Hypochlorous acid (HClO) is a potent broad-spectrum fast-acting antibacterial agent with a favourable safety profile [14]. In nasal formulations, it has shown bactericidal, fungicidal, or virucidal effects [15,16].…”