Improved microwave biosensor for non-invasive dielectric characterization of biological tissues

Deshours, Frédérique; Alquié, G.; Kokabi, Hamid; Rachedi, Kammel; Tlili, Malika; Hardinata, Satria; Koskas, Fabien

doi:10.1016/j.mejo.2018.01.027

Cited by 25 publications

(17 citation statements)

References 9 publications

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“…On 18 October 2011, the European Commission adopted the following definition of a nanomaterial: "A natural, incidental or manufactured material containing particles, in an unbound state or as an successfully used in the development of highly sensitive biosensors, also including enzymes, nucleic acids, deoxyribonucleic acid, living cells, biological tissues, etc. [32][33][34][35]. Carbonaceous nanomaterials have been also used as labels in electrochemical immunosensors and immunoassays.…”

Section: Nanomaterials Used In Development Of Electrochemical Sensorsmentioning

confidence: 99%

Carbonaceous Nanomaterials Employed in the Development of Electrochemical Sensors Based on Screen-Printing Technique—A Review

Bounegru

Apetrei

2020

Catalysts

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This paper aims to revise research on carbonaceous nanomaterials used in developing sensors. In general, nanomaterials are known to be useful in developing high-performance sensors due to their unique physical and chemical properties. Thus, descriptions were made for various structural features, properties, and manner of functionalization of carbon-based nanomaterials used in electrochemical sensors. Of the commonly used technologies in manufacturing electrochemical sensors, the screen-printing technique was described, highlighting the advantages of this type of device. In addition, an analysis was performed in point of the various applications of carbon-based nanomaterial sensors to detect analytes of interest in different sample types.

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Section: Nanomaterials Used In Development Of Electrochemical Sensorsmentioning

confidence: 99%

Carbonaceous Nanomaterials Employed in the Development of Electrochemical Sensors Based on Screen-Printing Technique—A Review

Bounegru

Apetrei

2020

Catalysts

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“…Permittivity measurements can be performed with different methods [8]: with a resonant cavity for high accuracy however this technique suppose manipulation of the sample, or with free-space method or transmission lines and resonant structures. The last method has already been used for measurement over chemical [9] or biological samples [10], [11]. In this case a resonant structure is loaded with the material under consideration, and the shift in the resonance frequency is correlated to the effective permittivity over the sensor.…”

Section: A State Of the Art Of High Frequency Measurementmentioning

confidence: 99%

“…This device also enables optical measurement for latter experiments (Ibidi -µ-Slide 2 Well Glass Bottom). Different structures of resonator can be found in the literature, the most commonly used shape is based on a ring resonator [10], [11]. The length of the resonator perimeter is directly linked to the resonance wavelength; in the case of a in vitro culture, cells will agglutinate around the place they are deposed, i.e.…”

Section: B Resonator Designmentioning

confidence: 99%

A microstrip resonator based sensor for GHz characterization of in vitro cell culture

Kolbl

Boulboul

Commereuc

et al. 2018

2018 12th International Conference on Sensing Technology (ICST)

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This contribution describes a sensor for GHz characterization of in vitro cell culture, that overcomes the limitation in high frequency of classical bio-impedance spectroscopy. The sensor we developed enables to monitor a thin layer of approximatively 30µm of cells in their liquid culture medium for a relative permittivity in the range of 5 to 55. Here, we demonstrate the measurement principle using a Finite Element model, which has been validated with experimental response. Our sensor has a minimal sensitivity of 0.3M Hz. We also used a multiphysics model to demonstrate that this technology does not affect tissue safety for input power level compatible with a sufficient measurement signal on noise ratio. This technology will be used in experiments aiming at the exploration of biomarkers for post-implantation inflammatory reactions of active devices.

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“…With regard to optical biosensors, it needs a long settling time for detection and is highly susceptible to change the test results for ambient light [33][34][35][36][37][38][39][40][41]. Recently, a biosensor based on radio frequency (RF) techniques has attracted enormous attention and is regarded as a promising and competitive candidate for implementing third-generation glucose biosensors [42][43][44][45][46][47]. Compared to other types of biosensors, RF biosensors offer the following advantages: first, they are different from the electrochemical biosensors, which are subject to the constraints of the use environment and performance degradation with service time.…”

Section: Introductionmentioning

confidence: 99%

Reusable, Non-Invasive, and Ultrafast Radio Frequency Biosensor Based on Optimized Integrated Passive Device Fabrication Process for Quantitative Detection of Glucose Levels

Yao

Yue

et al. 2020

Sensors

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The increase in the number of people suffering diabetes has been the driving force behind the development of glucose sensors to overcome the current testing shortcomings. In this work, a reusable, non-invasive and ultrafast radio frequency biosensor based on optimized integrated passive device fabrication process for quantitative detection of glucose level was developed. With the aid of the novel biosensor design with hammer-shaped capacitors for carrying out detection, both the resonance frequency and magnitude of reflection coefficient can be applied to map the different glucose levels. Meanwhile, the corresponding fabrication process was developed, providing an approach for achieving quantitative detection and a structure without metal-insulator-metal type capacitor that realizes low cost and high reliability. To enhance the sensitivity of biosensor, a 3-min dry etching treatment based on chlorine/argon-based plasma was implemented for realizing hydrophilicity of capacitor surface to ensure that the biosensor can be touched rapidly with glucose. Based on above implementation, a non-invasive biosensor having an ultrafast response time of superior to 0.85 s, ultralow LOD of 8.01 mg/dL and excellent reusability verified through five sets of measurements are realized. The proposed approaches are not limited the development of a stable and accurate platform for the detection of glucose levels but also presents a scheme toward the detection of glucose levels in human serum.

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Improved microwave biosensor for non-invasive dielectric characterization of biological tissues

Cited by 25 publications

References 9 publications

Carbonaceous Nanomaterials Employed in the Development of Electrochemical Sensors Based on Screen-Printing Technique—A Review

Carbonaceous Nanomaterials Employed in the Development of Electrochemical Sensors Based on Screen-Printing Technique—A Review

A microstrip resonator based sensor for GHz characterization of in vitro cell culture

Reusable, Non-Invasive, and Ultrafast Radio Frequency Biosensor Based on Optimized Integrated Passive Device Fabrication Process for Quantitative Detection of Glucose Levels

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