A microstrip resonator based sensor for GHz characterization of in vitro cell culture

Abstract

This contribution describes a sensor for GHz characterization of in vitro cell culture, that overcomes the limitation in high frequency of classical bio-impedance spectroscopy. The sensor we developed enables to monitor a thin layer of approximatively 30µm of cells in their liquid culture medium for a relative permittivity in the range of 5 to 55. Here, we demonstrate the measurement principle using a Finite Element model, which has been validated with experimental response. Our sensor has a minimal sensitivity of 0.3M Hz. We also used a multiphysics model to demonstrate that this technology does not affect tissue safety for input power level compatible with a sufficient measurement signal on noise ratio. This technology will be used in experiments aiming at the exploration of biomarkers for post-implantation inflammatory reactions of active devices.

Functionalised microwave sensors for real-time monitoring of copper and zinc concentration in mining-impacted water

“…reflection coefficient magnitude, as |S 11 |) provide a spectral response that depends on the composition and concentration of the MUT. Some of the advantages of this technique compared with optical and electrochemical methods are (i) the immediate measurement response when a water sample is in contact with the EM field; (ii) its noninvasiveness, considering this is a field-propagation-based technique (Kölbl et al 2018); (iii) its low power (1 mW) and measurement costs. Some of the disadvantages are related to the capability to detect every minor change in the MUT measurement, such as temperature and density (Al-Kizwini et al 2013).…”