Improved Lactic Acid Production by In Situ Removal of Lactic Acid During Fermentation and a Proposed Scheme for Its Recovery

Boonmee, Mallika; Cotano, Onanong; Amnuaypanich, Sittipong; Grisadanurak, Nurak

doi:10.1007/s13369-015-1824-5

Cited by 30 publications

(28 citation statements)

References 36 publications

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“…26 Th is method was also combined with reactive extraction using organic solvents, yielding up to 70% recovery of LA. 55 A two-step separation process including both anion and cation exchange chromatography was carried out with the fermentation broth of a novel substrate Zizyphus oenophlia, obtaining LA with 99% purity. 30 Th e combination of both electrodialysis and ion exchange results in a hybrid method called electrodeionization, allowing continuous membrane regeneration by an electric fi eld.…”

Section: Batch Fed-batch and Continuous Fermentationmentioning

confidence: 99%

Biotechnological advances in lactic acid production by lactic acid bacteria: lignocellulose as novel substrate

Cubas-Cano

González‐Fernández

Ballesteros

et al. 2018

Biofuels Bioprod Bioref

143

101

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The production of high added-value products from lignocellulose is proposed as a suitable alternative to petroleum-based resources in terms of environmental preservation, sustainability, and circular economy. Lactic acid is a versatile building block that can be produced via fermentative routes by several groups of microorganisms, including yeasts and microalgae, which are bacteria recognized to achieve the highest concentrations. Lactic acid, among other substances, can be used as a starting point in the production of poly-lactic acid, which is a biopolymer with many applications due to its resistance, durability, biodegradability, and biocompatibility. Lactic acid production can be performed from lignocellulosic biomass. However, lactic acid production from lignocellulose faces several hurdles such as carbohydrate hydrolysis to release sugars, the co-utilization of sugar mixtures by the fermenting microorganism, and the presence of degradation compounds released during pretreatment. In this review, a general overview of lactic-acid bacterial fermentation from lignocellulose is provided, starting from the potential substrates and their composition, the different metabolic pathways involved, and the purifi cation steps. The main challenges are discussed and the newest approaches to solve the limitations of the process are proposed.

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Section: Batch Fed-batch and Continuous Fermentationmentioning

confidence: 99%

Biotechnological advances in lactic acid production by lactic acid bacteria: lignocellulose as novel substrate

Cubas-Cano

González‐Fernández

Ballesteros

et al. 2018

Biofuels Bioprod Bioref

143

101

View full text Add to dashboard Cite

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“…Furthermore, the pH fall could also be prevented by combining different separation methods in order to avoid the accumulation of LA or acetic acid in the culture. In this sense, the combined effect of anion exchange and organic solvent extraction presented a high LA recovery yield in Lactococcus lactis fermentation . High LA yields were also obtained from glucose fermentation of Pediococcus pentosaceus coupled with the combination of electrodialysis and ion exchange extraction …”

Section: Resultsmentioning

confidence: 92%

“…In this sense, the combined effect of anion exchange and organic solvent extraction presented a high LA recovery yield in Lactococcus lactis fermentation. 35 High LA yields were also obtained from glucose fermentation of Pediococcus pentosaceus coupled with the combination of electrodialysis and ion exchange extraction. 36 Lactic acid production from WSH obtained with different hydrolysis methods…”

Section: Lactic Acid Production From Xylose In Wspmentioning

confidence: 99%

Lactobacillus pentosus CECT 4023 T co‐utilizes glucose and xylose to produce lactic acid from wheat straw hydrolysate: Anaerobiosis as a key factor

Cubas-Cano

González‐Fernández

Ballesteros

et al. 2018

Biotechnology Progress

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Lactic acid is a versatile chemical that can be produced via fermentation of lignocellulosic materials. The heterolactic strain Lactobacillus pentosus CECT 4023 T, that can consume glucose and xylose, was studied to produce lactic acid from steam exploded wheat straw prehydrolysate. The effect of temperature and pH on bacterial growth was analyzed. Besides, the effect of oxygen on lactic acid production was tested and fermentation yields were compared in different scenarios. This strain showed very high tolerance to the inhibitors contained in the wheat straw prehydrolysate. The highest lactic acid yields based on present sugar, around 0.80 g g−1, were obtained from glucose in presence of 25%, 50%, and 75% v v−1 of prehydrolysate in strict anaerobiosis. Lactic fermentation of wheat straw hydrolysate obtained after enzymatic hydrolysis of the prehydrolysate yielded 0.39 g of lactic acid per gram of released sugars, which demonstrated the high potential of L. pentosus to produce lactic acid from hemicellulosic hydrolysates. Results presented herein not only corroborated the ability of L. pentosus to grow using mixtures of sugars, but also demonstrated the suitability of this strain to be applied as an efficient lactic acid producer in a lignocellulosic biorefinery approach. © 2018 American Institute of Chemical Engineers Biotechnol. Prog., 35: e2739, 2019

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“…The recovery of this molecule from fermentation broths has been widely studied, and the ISPR approach has proved to enhance the productivity and yield of several lactic acid production processes (Boonmee et al, 2016;Gao et al, 2009;Wasewar et al, 2004). Liquidliquid reactive extraction stands out from the other approaches studied, because it can selectively remove acids from diluted solutions.…”

Section: Downstream Processesmentioning

confidence: 99%

Process engineering for microbial production of 3-hydroxypropionic acid

Fouchécour

Sánchez-Castañeda

Saulou‐Bérion

et al. 2018

Biotechnology Advances

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Due to concerns about the unsustainability and predictable shortage of fossil feedstocks, research efforts are currently being made to develop new processes for production of commodities using alternative feedstocks. 3-Hydroxypropionic acid (CAS 503-66-2) was recognised by the US Department of Energy as one of the most promising value-added chemicals that can be obtained from biomass. This article aims at reviewing the various strategies implemented thus far for 3-hydroxypropionic acid bioproduction. Special attention is given here to process engineering issues. The variety of possible metabolic pathways is also described in order to highlight how process design can be guided by their understanding. The most recent advances are described here in order to draw up a panorama of microbial 3-hydroxypropionic acid production: best performances to date, remaining hurdles and foreseeable developments. Important milestones have been achieved, and process metrics are getting closer to commercial relevance. New strategies are continuously being developed that involve new microbial strains, new technologies, or new carbon sources in order to overcome the various hurdles inherent to the different microbial routes.

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Improved Lactic Acid Production by In Situ Removal of Lactic Acid During Fermentation and a Proposed Scheme for Its Recovery

Cited by 30 publications

References 36 publications

Biotechnological advances in lactic acid production by lactic acid bacteria: lignocellulose as novel substrate

Biotechnological advances in lactic acid production by lactic acid bacteria: lignocellulose as novel substrate

Lactobacillus pentosus CECT 4023 T co‐utilizes glucose and xylose to produce lactic acid from wheat straw hydrolysate: Anaerobiosis as a key factor

Process engineering for microbial production of 3-hydroxypropionic acid

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