Improved endothelial function after a modified harvesting technique of the internal thoracic artery

Grapow, Martin

doi:10.1016/s1010-7940(03)00122-2

Cited by 8 publications

(6 citation statements)

References 16 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently published organ-bath studies have shown that a slight modification of the surgical technique of internal thoracic artery harvesting, avoiding blood stasis and alteration in wall tension, may significantly improve the preservation of endothelial function of the arterial graft [7]. In the present study plasma concentrations of soluble adhesion molecules of the selectin class, thrombomodulin and the morphological structures of the endothelial cell layer after the same surgical procedures were investigated.…”

Section: Discussionmentioning

confidence: 91%

“…We recently demonstrated the impact of internal thoracic artery preparation on endothelial function in vitro [7]. We compared the functional activity of the internal thoracic artery when prepared by the "traditional" harvesting technique with a slightly modified method.…”

Section: Introductionmentioning

confidence: 99%

“…nal thoracic artery, even for an extremely short time, diminishes the endothelium-dependent relaxation of the artery induced by acetylcholine, and increases the force of its contractile response to 5-hydroxytryptamine and endothelin-1, suggesting loss of the basal vasodilating properties of the endothelium [7]. Disturbing the critical balance between endothelium-derived relaxing and contracting factors is believed to predispose the vascular smooth muscle to increased tone, decreased vasomotion, changes in structure or geometry and, eventually, to atherosclerosis with graft failure.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Protecting the Endothelial Integrity of Internal Thoracic Arteries

Grapow

Konerding²,

Müller‐Schweinitzer³

et al. 2005

Thorac cardiovasc Surg

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Protecting the Endothelial Integrity of Internal Thoracic Arteries

Grapow

Konerding²,

Müller‐Schweinitzer³

et al. 2005

Thorac cardiovasc Surg

View full text Add to dashboard Cite

show abstract

“…They have reported that the clipped ITA had higher contractile responses compared to perfused ITA. But, they did not report the endothelial integrity and ultrastructurall changes of the conduits [13].…”

Section: Discussionmentioning

confidence: 97%

Histologic examination of the clipped internal thoracic artery by transmission electron microscope in patients undergoing coronary artery bypass grafting

Ozkara¹

2012

WJCD

View full text Add to dashboard Cite

Objectives: As we known that the internal thoracic artery (ITA) has an excellent patency rate in coronary artery bypass grafting (CABG). However, early graft failure due to occlusion and spasm is still the major problem after coronary artery bypass surgery. We examined histopathologic findings of the clipped internal thoracic artery (ITA) in patients undergoing CABG using transmission electron microscope (TEM). Methods: To investigate the histopathololojic ITA examination, 60 patients were randomly selected. The ITA was harvested in a standart fashion with the use of low voltage electrocotery and its distal end was cut prior to bifurcation and clipped. Just before the ITA anastomosis 1 mm lenght of ITA ring was cut and saved in 2.5% Glutaraldehide solution for fixation and examination of transmission electron microscope (TEM). One blinded anatomopatholog examined all specimens and described the endothelial integrity according to the score system proposed by Fischlein et al. Results: In ten cases (17.5%) different degree of histopathologic findings (endothelial cells, intercellular and intracellular organels and adventitia) were recorded The most important histopatholojic findings of ITA were as follows: endothelial vacuolisation, intimal thickening and/or intimal seperation, subendothelial edema, swallowing of cytoplasma and mitocondria. Conclusion: Our results showed that the endothelial pathology is high when the ITA clipped. Unfortunataly, because our study did not include the non-clipped ITA we have not concluded the comparison or statistical results. In our opinion, for absolute definition of the effects of the clipping the ITA it should be planned the comparative results between the clipped and non-clipped ITA histologic examinations.

show abstract

“…15 All grafts were harvested with the surrounding fat, and flushing with any spasmolytic solution or mechanical dilation of the vessel was strictly avoided.…”

Section: Methodsmentioning

confidence: 99%

Reactive oxygen species mediate functional differences in human radial and internal thoracic arteries from smokers

Müller‐Schweinitzer

Müller

Reineke

et al. 2010

Journal of Vascular Surgery

View full text Add to dashboard Cite

show abstract

Improved endothelial function after a modified harvesting technique of the internal thoracic artery

Abstract: These data suggest that leaving the ITA perfused during harvesting might improve considerably the endothelial function of the graft.

Cited by 8 publications

References 16 publications

Protecting the Endothelial Integrity of Internal Thoracic Arteries

Protecting the Endothelial Integrity of Internal Thoracic Arteries

Histologic examination of the clipped internal thoracic artery by transmission electron microscope in patients undergoing coronary artery bypass grafting

Reactive oxygen species mediate functional differences in human radial and internal thoracic arteries from smokers

Contact Info

Product

Resources

About