Protecting the Endothelial Integrity of Internal Thoracic Arteries

Abstract

Biochemical and structural results support our findings that leaving the internal thoracic artery perfused preserves endothelial function in the arterial graft.

All we need to know about internal thoracic artery harvesting and preparation for myocardial revascularization: a systematic review

“…There were also profound endothelial lining changes in the clipped group, while no signs of endothelial cell loss found in the perfused group under the electron microscope. So, their biochemical and electron microscopy results confirmed that perfused ITAs maintain the functional integrity of the endothelium while the functional integrity in the clipped artery is disrupted [ 64 ]. Another study performed a different research methodology to know the effect of clipping on ITAs' endothelium.…”

Does Endovenous Laser Ablation Induce Endothelial Damage at the Saphenofemoral Junction?

“…15 P-selectin and TM can be measured in plasma in their soluble ((s)) forms and have proved to be reliable indicators of platelet and endothelial activation. [16][17][18][19] It has been demonstrated that (s) P-selectin is released in unstable angina within the first 3 hours, 20 and (s) P-selectin is measurable within 30 minutes after percutaneous transluminal angioplasty (PTA). 21 In trauma patients, sTM has been found after 10 minutes.…”

“…TM suppresses blood coagulation and is an important component of the protein C anticoagulant pathway 15 . P‐selectin and TM can be measured in plasma in their soluble ((s)) forms and have proved to be reliable indicators of platelet and endothelial activation 16–19 . It has been demonstrated that (s) P‐selectin is released in unstable angina within the first 3 hours, 20 and (s) P‐selectin is measurable within 30 minutes after percutaneous transluminal angioplasty (PTA) 21 .…”