Reactive oxygen species mediate functional differences in human radial and internal thoracic arteries from smokers

Müller‐Schweinitzer, Else; Müller, Sandra; Reineke, David; Kern, Thomas; Carrel, Thierry; Eckstein, Friedrich S.; Grapow, Martin

doi:10.1016/j.jvs.2009.09.040

Cited by 19 publications

(5 citation statements)

References 37 publications

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“…The endothelium of IMAs is resistant to ROS and hence less susceptible to damage by external stimuli such as smoking or dyslipidemia. IMAs produce, at the baseline or after external stimulation, high levels of NO, rendering it a conduit with a better patency than the RA when tested in active smokers ( 33 ). The IMA endothelium also has fewer intercellular junctions and fenestrations as compared to the SVG endothelium, which may play a role in preventing the infiltration of lipoproteins into the subendothelial space of IMA ( 34 ).…”

Section: Conduits For Cabgmentioning

confidence: 99%

Conduits’ Biology Regulates the Outcomes of Coronary Artery Bypass Grafting

Gharibeh

Ferrari

Ouimet

et al. 2021

JACC: Basic to Translational Science

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Section: Conduits For Cabgmentioning

confidence: 99%

Conduits’ Biology Regulates the Outcomes of Coronary Artery Bypass Grafting

Gharibeh

Ferrari

Ouimet

et al. 2021

JACC: Basic to Translational Science

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“…In smokers the RA shows a higher vasoconstrictor response to ET-1 and an attenuated endotheliumdependent relaxation, probably due to enhanced production of reactive oxygen species [39]. In contrast, neither histopathologic nor morphometric differences were found between RA of patients older than 70 years and those of younger controls [40].…”

Section: Morpho-functional Features In Specific Patient Populationsmentioning

confidence: 88%

Morpho-Functional Features of the Radial Artery: Implications for Use as a Coronary Bypass Conduit

Gaudino¹,

Crea²,

Cammertoni³

et al. 2014

The Annals of Thoracic Surgery

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“…In accordance with previous findings [ 6 , 10 , 39 ], smoking and diabetes were found in our study to act as a trigger for accelerating RAP formation. Research has stated that in smokers, the RA is less responsive to acetylcholine and has enhanced reactive oxygen species compared with the internal mammary artery [ 40 ]. Subtle intimal defects caused by atherosclerosis provide potential risk of spasm and injury in revascularization, and may even be a mechanism for late graft failure [ 41 – 43 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of radial artery atherosclerosis in acute coronary syndrome patients: an in vivo study using optical coherence tomography

Tang

Wang

et al. 2022

BMC Cardiovasc Disord

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Background Radial artery (RA) atherosclerosis in acute coronary syndrome (ACS) patients has not been systematically observed in vivo. The study aims to characterize plaque morphology and intimal hyperplasia of the RA in patients with ACS, using optical coherence tomography (OCT). Methods In this retrospective study involving 239 ACS patients underwent RA OCT without guidewire shadow, 3 groups were divided according to the following criteria: radial artery plaque (RAP) group included patients with fibrous, lipid or calcified plaque; patients without RAP were further classified into radial intimal hyperplasia (RIH) group (intima media thickness ratio [IMR] ≥ 1) or normal group (IMR < 1). The presence and characteristics of RAP and its related risk factors were identified. Results The RAP, RIH and normal groups included 76 (31.8%), 69 (28.9%) and 94 (39.3%) patients, respectively. Patients in RAP group were the oldest, compared with those in the RIH and normal groups (p < 0.001), and more frequently had triple vessel disease (p = 0.004). The percentage of plaque rupture (72.4% vs. 56.4%, p = 0.018) and calcification (42.1% vs. 27.6%, p = 0.026) at culprit lesion were significantly higher in patients with RAP than those without RAP. A total of 148 RAP were revealed by OCT, including fibrous (72, 48.6%), lipid (50, 33.8%) and calcified plaques (26, 17.6%). The microvessels were also frequently observed in the RAP group than that in RIH and normal groups (59.2% vs. 8.7% vs. 9.6%, p < 0.001). Multivariate logistic regression analysis showed that age, diabetes, and smoking history (all p < 0.05) were independent risk factors for RAP. Conclusions In terms of insights gained from OCT, RA atherosclerosis is not uncommon in ACS patients by OCT, sharing several morphological characters with early coronary atherosclerosis. Aging, diabetes, and smoking are risk factors for RAP.

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Reactive oxygen species mediate functional differences in human radial and internal thoracic arteries from smokers

Cited by 19 publications

References 37 publications

Conduits’ Biology Regulates the Outcomes of Coronary Artery Bypass Grafting

Conduits’ Biology Regulates the Outcomes of Coronary Artery Bypass Grafting

Morpho-Functional Features of the Radial Artery: Implications for Use as a Coronary Bypass Conduit

Assessment of radial artery atherosclerosis in acute coronary syndrome patients: an in vivo study using optical coherence tomography

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