Improved drug delivery and accelerated diabetic wound healing by chondroitin sulfate grafted alginate-based thermoreversible hydrogels

Shah, Syed Ahmed; Sohail, Muhammad; Khan, Shujaat Ali; Kousar, Mubeen

doi:10.1016/j.msec.2021.112169

Cited by 67 publications

(30 citation statements)

References 113 publications

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“…The hydrogel was subcutaneously injected for 24 h followed by histological examination. The in vivo wound healing results showed the upregulation of fibroblasts-like cells, collagen deposition, and differentiated keratinocytes stimulating dermo-epidermal junction ( Shah et al, 2021 ).…”

Section: Design Considerationsmentioning

confidence: 99%

“…When designing wound dressing, they can be compounded with proteins to form glycoproteins to provide cells in the wound with a microenvironment similar to the ECM. In addition, polysaccharide molecules themselves can participate in the immune modulation process in the body, so designing a hydrogel with an appropriate degradation rate can promote wound healing from the perspective of immune regulation ( Schepetkin & Quinn, 2006 ; Shah et al, 2021 ).…”

Section: Design Considerationsmentioning

confidence: 99%

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Polysaccharide-Based Hydrogels for Wound Dressing: Design Considerations and Clinical Applications

Cui

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

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Wound management remains a worldwide challenge. It is undeniable that patients with problems such as difficulties in wound healing, metabolic disorder of the wound microenvironment and even severely infected wounds etc. always suffer great pain that affected their quality of lives. The selection of appropriate wound dressings is vital for the healing process. With the advances of technology, hydrogels dressings have been showing great potentials for the treatment of both acute wounds (e.g., burn injuries, hemorrhage, rupturing of internal organs/aorta) and chronic wounds such as diabetic foot and pressure ulcer. Particularly, in the past decade, polysaccharide-based hydrogels which are made up with abundant and reproducible natural materials that are biocompatible and biodegradable present unique features and huge flexibilities for modifications as wound dressings and are widely applicable in clinical practices. They share not only common characteristics of hydrogels such as excellent tissue adhesion, swelling, water absorption, etc., but also other properties (e.g., anti-inflammatory, bactericidal and immune regulation), to accelerate wound re-epithelialization, mimic skin structure and induce skin regeneration. Herein, in this review, we highlighted the importance of tailoring the physicochemical performance and biological functions of polysaccharide-based hydrogel wound dressings. We also summarized and discussed their clinical states of, aiming to provide valuable hints and references for the future development of more intelligent and multifunctional wound dressings of polysaccharide hydrogels.

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Section: Design Considerationsmentioning

confidence: 99%

Section: Design Considerationsmentioning

confidence: 99%

Polysaccharide-Based Hydrogels for Wound Dressing: Design Considerations and Clinical Applications

Cui

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

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“…Hydrogels prepared with various ratios of hyaluronic acid, Pluronic F-127, and κ-carrageenan were transferred into glass vials. All vials were kept in a water bath at 25 • C and the temperature was slowly increased to 37 • C. The thermosensitive behavior of developed formulations was evaluated by increasing the temperature [34,35].…”

Section: Sol-gel Phase Transition (T Sol-gel )mentioning

confidence: 99%

“…The FTIR spectra (Figure 1B) of the κ-carrageenan showed that the bands appeared at 847.35, 907.85, 1189.78, and 1208.65 cm −1 due to D-galactose-4-sulfate, glycosidic linkage, 3,6-anhydrous-D-galactose, and the ester sulfate stretching of the backbone of κ-carrageenan, respectively [33,34]. The bands at 1541.35, 1564.70, and 1649.20 cm −1 were due to functional groups such as carboxamide or carboxylate [35]. These bands are recognized by C=O stretching in carboxamide functional groups and the asymmetric as well as symmetric stretching of carboxylate functional groups.…”

Section: Ftirmentioning

confidence: 99%

Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing

et al. 2022

Self Cite

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The in situ injectable hydrogel system offers a widespread range of biomedical applications in prompt chronic wound treatment and management, as it provides self-healing, maintains a moist wound microenvironment, and offers good antibacterial properties. This study aimed to develop and evaluate biopolymer-based thermoreversible injectable hydrogels for effective wound-healing applications and the controlled drug delivery of meropenem. The injectable hydrogel was developed using the solvent casting method and evaluated for structural changes using proton nuclear magnetic resonance, Fourier transforms infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy. The results indicated the self-assembly of hyaluronic acid and kappa-carrageenan and the thermal stability of the fabricated injectable hydrogel with tunable gelation properties. The viscosity assessment indicated the in-situ gelling ability and injectability of the hydrogels at various temperatures. The fabricated hydrogel was loaded with meropenem, and the drug release from the hydrogel in phosphate buffer saline (PBS) with a pH of 7.4 was 96.12%, and the simulated wound fluid with a pH of 6.8 was observed to be at 94.73% at 24 h, which corresponds to the sustained delivery of meropenem. Antibacterial studies on P. aeruginosa, S. aureus, and E. coli with meropenem-laden hydrogel showed higher zones of inhibition. The in vivo studies in Sprague Dawley (SD) rats presented accelerated healing with the drug-loaded injectable hydrogel, while 90% wound closure with the unloaded injectable hydrogel, 70% in the positive control group (SC drug), and 60% in the negative control group was observed (normal saline) after fourteen days. In vivo wound closure analysis confirmed that the developed polymeric hydrogel has synergistic wound-healing potential.

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“…The cytotoxicity analysis and pharmacokinetic profile of the hydrogel showed that the hydrogel increased the drug release time and had no cytotoxicity toward fibroblasts. 14 Han et al prepared a silver nanoparticles/gelatin hydrogel containing silver nanoparticles (AgNPs) for bone regeneration, which significantly enhanced the alkaline phosphatase (ALP) levels and mineralization in vitro. 15 Similarly, Kamel et al used a calcium-enriched nanofibrillated cellulose hydrogel for bone engineering tissue.…”

Section: Introductionmentioning

confidence: 99%

A Composite Deferoxamine/Black Phosphorus Nanosheet/Gelatin Hydrogel Scaffold for Ischemic Tibial Bone Repair

Xu¹,

Gan²,

Wang³

et al. 2022

IJN

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Introduction Bone delay union is mostly caused by lack of blood supply. Although autografts, allografts and artificial bone have been widely used to treat bone delay union, the bone regeneration fails in the ischemic site accompanied by the bone donor site complications and disease transmission. Recently, there is a growing recognition of the importance of hydrogel scaffolds which are regarded as an eligible engineer tissue for bone repair. However, hydrogel is still limited in improving neovascularization. Methods In this work, black phosphorus nanosheet and deferoxamine (BPN-DFO) were loaded in the gelatin hydrogel to overcome the high risk of bone delay union and systemically investigated the regeneration capability of BPN-DFO hydrogel in vitro and vivo. Results The resulting BPN-DFO hydrogel scaffold showed superior swollen, degradation and release rate, as well as satisfied biocompatibility. BPN-DFO hydrogel shown the significant up-expression of mRNA related to bone regeneration and cell proliferation. In vivo, the proposed BPN-DFO hydrogel significantly improved osteogenesis and neovascularization in the ischemic tibial bone site of SD rats with acute femoral artery occlusion. Both macroscopic and histological evaluation of new regenerated bone showed newly formed blood vessel and collagen using BPN-DFO hydrogel. The immunohistochemistry and RT-PCR revealed that the bone regeneration could be improved via BMP/Runx2 pathway. Conclusion The BPN-DFO hydrogel possesses potential tissue engineer material for ischemic bone defect treatment. However, furthermore studies are needed to testify the safety and efficacy of BPN-DFO hydrogel.

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Improved drug delivery and accelerated diabetic wound healing by chondroitin sulfate grafted alginate-based thermoreversible hydrogels

Cited by 67 publications

References 113 publications

Polysaccharide-Based Hydrogels for Wound Dressing: Design Considerations and Clinical Applications

Polysaccharide-Based Hydrogels for Wound Dressing: Design Considerations and Clinical Applications

Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing

A Composite Deferoxamine/Black Phosphorus Nanosheet/Gelatin Hydrogel Scaffold for Ischemic Tibial Bone Repair

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