A Composite Deferoxamine/Black Phosphorus Nanosheet/Gelatin Hydrogel Scaffold for Ischemic Tibial Bone Repair

Xu, Dingli; Gan, Kaifeng; Wang, Yan; Wu, Zeting; Wang, Yulong; Zhang, Song; Peng, Yujie; Fang, Xuguang; Wei, Hua; Zhang, Yansheng; Ma, Weihu; Chen, Jing

doi:10.2147/ijn.s351814

Cited by 14 publications

(2 citation statements)

References 57 publications

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“…In vivo studies from a model of a skull lesion in a rabbit shown that BPNs accelerated bone repair. Xu et al [ 37 ] prepared scaffolds by loading BPNs and deferoxamine (BPN-DFO) into gelatin hydrogels using a similar approach. In ischemic tibial areas of SD (Sprague Dawley) rats with acute femoral artery blockage, the scaffolds displayed excellent swelling, degradation, and release rates, and significantly enhanced osteogenesis and blood vessel development.…”

Section: Biomedical Application Of Black Phosphorus Hybrids Hydrogelmentioning

confidence: 99%

Research progress on black phosphorus hybrids hydrogel platforms for biomedical applications

Zhao

Jiang

et al. 2023

J Biol Eng

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Hydrogels, also known as three-dimensional, flexible, and polymer networks, are composed of natural and/or synthetic polymers with exceptional properties such as hydrophilicity, biocompatibility, biofunctionality, and elasticity. Researchers in biomedicine, biosensing, pharmaceuticals, energy and environment, agriculture, and cosmetics are interested in hydrogels. Hydrogels have limited adaptability for complicated biological information transfer in biomedical applications due to their lack of electrical conductivity and low mechanical strength, despite significant advances in the development and use of hydrogels. The nano-filler-hydrogel hybrid system based on supramolecular interaction between host and guest has emerged as one of the potential solutions to the aforementioned issues. Black phosphorus, as one of the representatives of novel two-dimensional materials, has gained a great deal of interest in recent years owing to its exceptional physical and chemical properties, among other nanoscale fillers. However, a few numbers of publications have elaborated on the scientific development of black phosphorus hybrid hydrogels extensively. In this review, this review thus summarized the benefits of black phosphorus hybrid hydrogels and highlighted the most recent biological uses of black phosphorus hybrid hydrogels. Finally, the difficulties and future possibilities of the development of black phosphorus hybrid hydrogels are reviewed in an effort to serve as a guide for the application and manufacture of black phosphorus -based hydrogels. Graphical Abstract Recent applications of black phosphorus hybrid hydrogels in biomedicine.

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Section: Biomedical Application Of Black Phosphorus Hybrids Hydrogelmentioning

confidence: 99%

Research progress on black phosphorus hybrids hydrogel platforms for biomedical applications

Zhao

Jiang

et al. 2023

J Biol Eng

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“…In contrast, in situ hydrogels fabricated with calcium-enriched nano-fibrillated cellulose exhibited improved biocompatibility, cell attachment, alkaline phosphatase, and calcium deposition activity [62]. Hydroxyapatite, being one of the most biocompatible agents, combined with cellulose to develop into nanocomposites for bone cell proliferation, were three-dimensionally printed and evaluated for the sustained release of strontium and calcium ions and substantial proliferation, bone marrow stem cell differentiation, and bone tissue revival [63]. In another study, cellulose nanocrystals doped with gelatin and alginate developed into 3D-printed hydrogel scaffolds presented considerable matrix mineralization in the bone tissue [64].…”

Section: Cellulosementioning

confidence: 99%

Polymeric Theragnostic Nanoplatforms for Bone Tissue Engineering

Banerjee

Madhyastha

2023

JNT

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Nanomaterial-based tissue engineering strategies are precisely designed and tweaked to contest specific patient needs and their end applications. Though theragnostic is a radical term very eminent in cancer prognosis, of late, theragnostic approaches have been explored in the fields of tissue remodulation and reparation. The engineering of theragnostic nanomaterials has opened up avenues for disease diagnosis, imaging, and therapeutic treatments. The instantaneous monitoring of therapeutic strategy is expected to co-deliver imaging and pharmaceutical agents at the same time, and nanoscale carrier moieties are convenient and efficient platforms in theragnostic applications, especially in soft and hard tissue regeneration. Furthermore, imaging modalities have extensively contributed to the signal-to-noise ratio. Simultaneously, there is an accumulation of high concentrations of therapeutic mediators at the defect site. Given the confines of contemporary bone diagnostic systems, the clinical rationale demands nano/biomaterials that can localize to bone-diseased sites to enhance the precision and prognostic value for osteoporosis, non-healing fractures, and/or infections, etc. Furthermore, bone theragnostics may have an even greater clinical impact and multimodal imaging procedures can overcome the restrictions of individual modalities. The present review introduces representative theragnostic polymeric nanomaterials and their advantages and disadvantages in practical use as well as their unique properties.

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Black Phosphorus Accelerates Bone Regeneration Based on Immunoregulation

Qiu,

Tulufu,

Tang

et al. 2023

Advanced Science

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A fundamental understanding of inflammation and tissue healing suggests that the precise regulation of the inflammatory phase, both in terms of location and timing, is crucial for bone regeneration. However, achieving the activation of early inflammation without causing chronic inflammation while facilitating quick inflammation regression to promote bone regeneration continues to pose challenges. This study reveals that black phosphorus (BP) accelerates bone regeneration by building an osteogenic immunological microenvironment. BP amplifies the acute pro‐inflammatory response and promotes the secretion of anti‐inflammatory factors to accelerate inflammation regression and tissue regeneration. Mechanistically, BP creates an osteoimmune‐friendly microenvironment by stimulating macrophages to express interleukin 33 (IL‐33), amplifying the inflammatory response at an early stage, and promoting the regression of inflammation. In addition, BP‐mediated IL‐33 expression directly promotes osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), which further facilitates bone repair. To the knowledge, this is the first study to reveal the immunomodulatory potential of BP in bone regeneration through the regulation of both early‐stage inflammatory responses and later‐stage inflammation resolution, along with the associated molecular mechanisms. This discovery serves as a foundation for the clinical use of BP and is an efficient approach for managing the immune microenvironment during bone regeneration.

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A Composite Deferoxamine/Black Phosphorus Nanosheet/Gelatin Hydrogel Scaffold for Ischemic Tibial Bone Repair

Cited by 14 publications

References 57 publications

Research progress on black phosphorus hybrids hydrogel platforms for biomedical applications

Research progress on black phosphorus hybrids hydrogel platforms for biomedical applications

Polymeric Theragnostic Nanoplatforms for Bone Tissue Engineering

Black Phosphorus Accelerates Bone Regeneration Based on Immunoregulation

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