Improved drug carriage and protective potential against Cisplatin-induced toxicity using Boldine-loaded PLGA nanoparticles

Mondal, Jesmin; Patra, Mousumi; Panigrahi, A. K.; Khuda‐Bukhsh, Anisur Rahman

doi:10.1016/j.jaim.2017.11.002

Cited by 15 publications

(8 citation statements)

References 44 publications

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“…Recent studies have focused on the use of poly(lactide- co -glycolic) acid as a material for the synthesis of nanoparticles to encapsulate therapeutic agents for the treatment of Alzheimer’s disease [42] and brain cancer [43,44]. In vitro studies showed that the use of polymeric nanoparticles enhanced drug delivery to the brain, with reduced oxidative stress, inflammation and plaque load through the improved delivery of curcumin for treating Alzheimer’s disease [42], and efficient internalization of doxorubicin into the human glioma cells, resulting in cytotoxic effect on cancer cells [43].…”

Section: Nanotechnology Approaches For Crossing the Blood-brain Bamentioning

confidence: 99%

“…In vitro studies showed that the use of polymeric nanoparticles enhanced drug delivery to the brain, with reduced oxidative stress, inflammation and plaque load through the improved delivery of curcumin for treating Alzheimer’s disease [42], and efficient internalization of doxorubicin into the human glioma cells, resulting in cytotoxic effect on cancer cells [43]. Additionally, the in vivo experiment regarding the co-delivery of cisplatin and boldine, an antioxidant agent, using the poly(lactide- co -glycolic) nanocarriers resulted in an effective target-specific delivery for therapeutic use in brain cancer therapy [44]. Furthermore, the use of a positively charged polymer, poly(ethylene imine) [45], and of the poly(ethylene imine)-poly( l -lysine) copolymer [46] as gene delivery vehicles has been reported.…”

Section: Nanotechnology Approaches For Crossing the Blood-brain Bamentioning

confidence: 99%

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Blood-Brain Delivery Methods Using Nanotechnology

et al. 2018

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Pathologies of the brain, of which brain cancer, Alzheimer’s disease, Parkinson’s disease, stroke, and multiple sclerosis, are some of the most prevalent, and that presently are poorly treated due to the difficulties associated with drug development, administration, and targeting to the brain. The existence of the blood-brain barrier, a selective permeability system which acts as a local gateway against circulating foreign substances, represents the key challenge for the delivery of therapeutic agents to the brain. However, the development of nanotechnology-based approaches for brain delivery, such as nanoparticles, liposomes, dendrimers, micelles, and carbon nanotubes, might be the solution for improved brain therapies.

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Section: Nanotechnology Approaches For Crossing the Blood-brain Bamentioning

confidence: 99%

Section: Nanotechnology Approaches For Crossing the Blood-brain Bamentioning

confidence: 99%

Blood-Brain Delivery Methods Using Nanotechnology

et al. 2018

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“…Studies regarding the treatment of brain cancer focused on the delivery of various anti-cancer drugs using nanocarriers. Specifically, poly(lactide- co -glycolic) acid nanoparticles containing doxorubicin, cisplatin, and boldine resulted in an efficient internalization into the glioma cells, inducing cytotoxic effects [86] and an effective target-specific delivery [87]. Other polymeric nanocarriers for the treatment of brain cancer include polyethylene glycol and poly(ω-pentadecalactone- co - p -dioxanone) [88] or polyethylene glycol and poly(lactic- co -glycolic) acid [89] block copolymer nanoparticles which led to an improved drug release efficiency and a decrease in tumor size.…”

Section: Nanomedicine In Central Nervous System Disordersmentioning

confidence: 99%

Neuronanomedicine: An Up-to-Date Overview

et al. 2019

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The field of neuronanomedicine has recently emerged as the bridge between neurological sciences and nanotechnology. The possibilities of this novel perspective are promising for the diagnosis and treatment strategies of severe central nervous system disorders. Therefore, the development of nano-vehicles capable of permeating the blood–brain barrier (BBB) and reaching the brain parenchyma may lead to breakthrough therapies that could improve life expectancy and quality of the patients diagnosed with brain disorders. The aim of this review is to summarize the recently developed organic, inorganic, and biological nanocarriers that could be used for the delivery of imaging and therapeutic agents to the brain, as well as the latest studies on the use of nanomaterials in brain cancer, neurodegenerative diseases, and stroke. Additionally, the main challenges and limitations associated with the use of these nanocarriers are briefly presented.

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“…The ease of PLGA nanoparticle functionalization, and biodegradability are the major features that make it a suitable candidate for drug delivery. (5,6) Coating of blood brain targeting nanoparticles with a surfactant such as polysorbate 80 is one of the strategies to deliver drug molecules to brain in a more effective way. 7The polysorbate 80 coating enables receptor-mediated endocytosis across the blood-brain barrier by adsorbing to plasma proteins such as apolipoprotein E. The method proved far more efficient as drug delivery system compared to the free drug used.…”

Section: Introductionmentioning

confidence: 99%