Improved determination of tramadol hydrochloride in biological fluids and pharmaceutical preparations utilizing a modified carbon paste electrode

Shawish, Hazem M. Abu; Ghalwa, Nasser Abu; Zaggout, Faried R.; Saadeh, Salman M.; Aldalou, Ayoub R.; Assi, Anwar A. Abou

doi:10.1016/j.bej.2009.10.019

Cited by 36 publications

(19 citation statements)

References 32 publications

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“…Table I depicts a comparison of BDD electrode analytical performance created in this study with the other electroanalytical studies in earlier published report. As understood from this table, BDD electrode presented a more sensitive electroanalytical response than modified carbon paste electrode (M-CPE) 12 , coated wire electrode (CWE) 23 , carbon nanoparticles glassy carbon electrode (CNPs/GCE) 24 and multiwalled carbon nanotube glassy carbon (MWCNT/ /GCE) 25 electrodes. However, some electroanalytical studies 1, 3,13,14,[26][27][28][29] reported in the literature shown higher sensitivity than the developed method.…”

Section: Effect Of Anionic Surfactantmentioning

confidence: 85%

“…Therefore, its determination in biological samples such as blood, urine, and serum are great importance because the results of analyses provide information about long-term abuse and can also be used for forensic purposes 2-6 . To date, a number of studies have been performed including high performance liquid chromatography 7,8 , spectrophotometry 9 , electrochemiluminescence 10 , gas chromatography 11 and electrochemical methods [12][13][14] for quantitative analysis of TRH from drugs, biological fluids, environmental water samples. Electrochemical methods, one of these methods, provide not only benefits such as speed, precision, selectivity and cost compliance for chemical analysis, but also provide useful information about the oxido-reduction mechanism of the corresponding electroactive species.…”

Section: Introductionmentioning

confidence: 99%

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Determination of tramadol in pharmaceutical forms and urine samples using a boron-doped diamond electrode

Keskin

Allahverdiyeva

Şeyho

et al. 2020

JSCS

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The present work describes the electroanalytical investigation and a novel voltammetric method for a cheap, fast and simple quantification of tramadol (TRH) using a boron-doped diamond (BDD) electrode. TRH displayed one well-defined, irreversible and adsorption-controlled oxidation peak at about +1.58 V (vs. Ag/AgCl) in Britton-Robinson buffer (BR, 0.1 mol L -1 , pH 3.0) using cyclic voltammetry (CV) technique. The voltammetric responses of the oxidation peaks are dependent on pH and its sensitivity was significantly enhanced in the existence of surfactant media (sodium dodecyl sulphate, SDS). In optimized experiment conditions, employing square-wave stripping mode, it was found that there was an excellent correlation between oxidation peak current and TRH concentration in the range of 0.25 to 50.0 μg mL -1 (8.34×10 -7 --1.67×10 -4 mol L -1 ), with a detection limit of 0.072 μg mL -1 (2.40×10 -7 mol L -1 ) in 0.1 mol L -1 BR buffer (pH 3.0) solution comprising 8×10 -4 mol L -1 SDS at +1.52 V (after 30 s accumulation at open-circuit condition). The developed approach can be used for the quantification of TRH in the pharmaceutical formulations and the spiked human urine samples with acceptable recoveries.

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Section: Effect Of Anionic Surfactantmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Determination of tramadol in pharmaceutical forms and urine samples using a boron-doped diamond electrode

Keskin

Allahverdiyeva

Şeyho

et al. 2020

JSCS

View full text Add to dashboard Cite

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“…The spectrofluorimetry [16], HPLC with DAD detection [17], HPLC with UV detection [18][19][20], HPLC with fluorescence detection [21][22][23][24], LC/PDA-ESI-MS/MS [24], potentiometry [25,26], square-wave voltammetric method with amperometric detection [27], gas chromatography with mass spectrophotometer [28,29], gas chromatography with nitrogen-phosphorus detection [30], HPTLC [31][32][33] methods reported for the determination of TDL are sensitive enough but require expensive or sophisticated instruments, involve procedures with rigorous control of the experimental conditions, require long and tedious pretreatment of the samples and laborious clean up procedures prior to analysis and are not simple for routine analysis. However, spectrophotometric methods are particularly attractive because of ease in accessibility and their quick applicability to routine analysis.…”

Section: Introductionmentioning

confidence: 99%

Enzymatic Assay of Opioid Analgesic, Tramadol, Using Horseradish Peroxidase

N¹,

Srilakshmi

Alekya³

et al. 2014

ILNS

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Three novel and sensitive enzymatic methods have been developed for the quantification of tramadol in pharmaceutical dosage forms. The proposed methods are based on the reaction of tramadol with 3-methylbenzothiazoline-2-one hydrazone (method A), aniline (method B) and aminoantipyrine in the presence of hydrogen peroxide and horseradish peroxidase to give colored complexes. The colored complexes obtained with 3-methylbenzothiazoline-2-one hydrazone, aniline and aminoantipyrine exhibit absorption maxima at 480 nm, 550 nm and 530 nm, respectively. Regression analysis of Beer's plots showed good correlation for tramadol in the concentration range (μg/mL) 2-12 for the methods A & B and 4-24 for the method C. The experimental parameters were studied and optimized. The precision and accuracy of the methods were satisfactory. The proposed methods were successfully applied for the quantification of tramadol in 3 brands of commercially available tablet dosage forms. The results were compared satisfactorily with the official method.

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“…Paracetamol or acetaminophen (APAP) and morphine are two analgesic drugs widely used for the treatment of pain and fever. However, over dosage results in liver and kidney damage and may lead to death [79,80]. Therefore, it is necessary to investigate the simultaneous separation of these compounds with TZ at the modified electrode.…”

Section: Interference Studymentioning

confidence: 99%

“…Determination of TZ may be interfering with co-existing biological compounds in the human fluid such as ascorbic acid, uric acid [78,79], dopamine [79] and paracetamol [79,80]. Paracetamol or acetaminophen (APAP) and morphine are two analgesic drugs widely used for the treatment of pain and fever.…”

Section: Interference Studymentioning

confidence: 99%

Ionic Liquid Crystals Modifier for Selective Determination of Terazosin Antihypertensive Drug in Presence of Common Interference Compounds

Atta

BinSabt

Hassan³

et al. 2017

Crystals

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Electrochemical sensor was fabricated based on carbon paste electrode modified with an ionic liquid crystal ILC (2-chloro-1,3-dimethyl-imidazolidinium hexafluorophosphate) in presence of sodium dodecyl sulfate for the selective electrochemical determination of Terazosin (TZ) in presence of common interference compounds. The electrode performance was compared in presence of other ionic liquids ILs (1-Butyl-4-methyl pyridinium tetrafluoroborate) and (1-n-Hexyl-3-methyl imidazolium tetrafluoroborate). Ultrasensitive determination of Terazosin HCl at the ILC modified electrode in the linear dynamic ranges of 0.002 to 0.09 µmol·L −1 and 0.2 to 30 µmol·L −1 with correlation coefficients 0.996 and 0.995 and LODs 1.69 × 10 −11 mol·L −1 and 6.43 × 10 −9 mol·L −1 , respectively, were obtained. Selective determination of TZ in presence of uric acid and ascorbic acid and simultaneous determination of binary mixtures of TZ/dopamine, TZ/paracetamol and TZ/Morphine were also determined successfully using the modified sensor.

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Improved determination of tramadol hydrochloride in biological fluids and pharmaceutical preparations utilizing a modified carbon paste electrode

Cited by 36 publications

References 32 publications

Determination of tramadol in pharmaceutical forms and urine samples using a boron-doped diamond electrode

Determination of tramadol in pharmaceutical forms and urine samples using a boron-doped diamond electrode

Enzymatic Assay of Opioid Analgesic, Tramadol, Using Horseradish Peroxidase

Ionic Liquid Crystals Modifier for Selective Determination of Terazosin Antihypertensive Drug in Presence of Common Interference Compounds

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