Improved Determination of Mebeverine Hydrochloride in Urine, Serum and Pharmaceutical Preparations Utilizing a Modified Carbon Paste Electrode

Ali, Tamer Awad; Omar, M. M.; Abdrabou, Veronia N.

doi:10.1016/s1452-3981(23)04859-9

Cited by 22 publications

(1 citation statement)

References 34 publications

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“…To ascertain the specificity of the suggested method, recovery studies were carried out by standard addition technique, by adding 25 ml aliquots (10 −5 −10 −3 mol l −1 ) of drug solution to 25 ml (10 −3 mol l −1 ) of pharmaceutical solution. [57][58][59][60] The drug concentration in sample solution was calculated by recording the change in mV reading for each increment using the following equation:…”

Section: Methodsmentioning

confidence: 99%

Optimization of Highly Sensitive Screen Printed Electrode Modified With Cerium (IV) Oxide Nanoparticles for Electrochemical Determination of Oxymetazoline Hydrochloride Using Response Surface Methodology

Abdel-Raoof

Abdel-Monem

Almrasy

et al. 2020

J. Electrochem. Soc.

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In the present work, a sensitive optimized electrochemical screen-printed electrode chemically modified with cerium nanoparticles was assigned for the determination of oxymetazoline hydrochloride. The sensing membrane was based on incorporation of ion paring agent i.e. tetraphenylborate associated with the drug as an electroactive material. Asides, paraffin oil was used as a pasting liquid for in this screen-printed electrode whereas cerium nanoparticles, commonly known as nanoceria, were used as oxide ion conductors to increase the electrode surface area and electrical conductivity. Optimization of the experimental parameters was performed using a response surface methodology which enables a graphical clarification of the linkage between different experimental factors and the slope response. The modified sensor with cerium nanoparticles displays a stable and significant linear response with a reproducible potential for five months at Nernstian slope of 59.07 ± 0.76 mV decade−1 over the concentration range (5 × 10−6−1 × 10−2 mol.l−1) at 25 ± oC with a detection limit of 9.72 × 10−7 mol l−1. Furthermore, the proposed approach was successfully used for the analysis of the drug in its pure and dosage form.

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Section: Methodsmentioning

confidence: 99%

Optimization of Highly Sensitive Screen Printed Electrode Modified With Cerium (IV) Oxide Nanoparticles for Electrochemical Determination of Oxymetazoline Hydrochloride Using Response Surface Methodology

Abdel-Raoof

Abdel-Monem

Almrasy

et al. 2020

J. Electrochem. Soc.

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Economic Electrochemical Sensors for the Determination of Eszopiclone in Pharmaceutical Formulation with Greenness Profile Assessment

et al. 2022

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Electrochemical‐ion‐selective‐sensors offer green, rapid, economic and simple analytical‐tool in pharmaceutical industry, control processes, physiological measurements and environmental monitoring. In this study, two sensors were introduced for eszopiclone (EZP) determination in pure‐form and in pharmaceutical‐dosage‐forms using drug‐ion‐exchanger association complex fabrication technique. Two different ion‐exchangers were used and compared, tetrakis (4‐chlorophenyl) borate in sensor1 and tetraphenyl borate in sensor 2. Such sensors showed superior performance at pH 3.5 over a wide‐range of EZP concentration. The proposed method was also assessed using GAPI and analytical Eco‐scale. Low cost, short analysis‐time, simplicity and greenness of the proposed sensors allow their use for high‐through‐put analysis in quality‐control laboratories.

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Utility of gold nanoparticles/silica modified electrode for rapid selective determination of mebeverine in micellar medium: comparative discussion and application in human serum

Salama

Zaazaa

Azab

et al. 2015

Ionics

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Improved Determination of Mebeverine Hydrochloride in Urine, Serum and Pharmaceutical Preparations Utilizing a Modified Carbon Paste Electrode

Cited by 22 publications

References 34 publications

Optimization of Highly Sensitive Screen Printed Electrode Modified With Cerium (IV) Oxide Nanoparticles for Electrochemical Determination of Oxymetazoline Hydrochloride Using Response Surface Methodology

Optimization of Highly Sensitive Screen Printed Electrode Modified With Cerium (IV) Oxide Nanoparticles for Electrochemical Determination of Oxymetazoline Hydrochloride Using Response Surface Methodology

Economic Electrochemical Sensors for the Determination of Eszopiclone in Pharmaceutical Formulation with Greenness Profile Assessment

Utility of gold nanoparticles/silica modified electrode for rapid selective determination of mebeverine in micellar medium: comparative discussion and application in human serum

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