Utility of gold nanoparticles/silica modified electrode for rapid selective determination of mebeverine in micellar medium: comparative discussion and application in human serum

Graphite Studded with Facile-Synthesized Cu2O Nanoparticle-Based Cubes as a Novel Electrochemical Sensor for Highly Sensitive Voltametric Determination of Mebeverine Hydrochloride

“…The literature survey reveals several analytical methods for MEB quantification, such as chromatographic [21,22], GC-MS [23], spectrophotometric [24,25], spectrofluorometric [25,26] and electrochemical methods [27][28][29][30][31][32][33]. Carbon paste electrodes (CPEs) have been applied successfully for MEB quantification either using potentiometric [31] or voltametric techniques [32,33]. This can be attributed to their low cost, low background currents, possibility to be used over a wide studied potential window, ease of surface renewability as well as modification simplicity and utilization variety when compared with other solid electrodes [34][35][36][37].…”

A Green Method for the Determination of Mebeverine in Its Pharmaceutical Products and Human Serum Based On Diatom Modified Carbon Paste Electrode Using Square Wave Adsorptive Anodic Stripping Voltammetry (SW-AdASV)

“…1) potent direct antispasmodic agent used mainly for the smooth muscles of the gastrointestinal tract and particularly effective against the colonic spasm [1] It is used in the treatment of abdominal pain and spasm associated with gastrointestinal disorders such as mucous colitis [2] Due to the vital importance of MV.HCl, there are many reported methods for its determination in its pharmaceutical formulations and in biological fluids. Among these methods are HPLC [3][4][5][6][7], spectrophotometry [8][9][10][11], GC-MS [12], and electrochemistry [13][14][15][16]. On one side, most of the reported chromatographic is expensive method of analysis required a high maintenance cost, high acquisition cost, time-consuming procedures, senetive equilibration, it also may requires derivatization treatment prior to analysis and expensive grades of reagents, eluents, and equipment [3][4][5][6][7]12], On other side, there are some reported electrochemical methods based on potentiometry [13], square-wave anodic stripping voltammetry (SW-ASV) [14,16] and differential pulse voltammetry (DPV) [15] listed in (Table 1).…”

“…Among these methods are HPLC [3][4][5][6][7], spectrophotometry [8][9][10][11], GC-MS [12], and electrochemistry [13][14][15][16]. On one side, most of the reported chromatographic is expensive method of analysis required a high maintenance cost, high acquisition cost, time-consuming procedures, senetive equilibration, it also may requires derivatization treatment prior to analysis and expensive grades of reagents, eluents, and equipment [3][4][5][6][7]12], On other side, there are some reported electrochemical methods based on potentiometry [13], square-wave anodic stripping voltammetry (SW-ASV) [14,16] and differential pulse voltammetry (DPV) [15] listed in (Table 1). It is noticed that Potentiometry and SW-AdASV onto bare Carbon paste electrode CPE did not offer a sufficient sensitive quantitation limit of MV.HCl that can cover pharmacokinetic studies and therapeutic drug monitoring.…”

“…mL -1 (< 2.15×10 -8 M) after a single oral dose of 405 mg of mebeverine hydrochloride [6] or in the range of 25 to 0.73 ng mL -1 (5.36×10 -8 M to 1.57×10 -9 M) after oral administration of two Colona ® tablets (100 mg Mebeverine + 25 mg Sulpiride) [7]. The other SW-AdASV using gold nanoparticles/silica gel [15] indicated narrow linear segment variations of the (i p ) with MV.HCl conc. in addition to hard procedures of preparation and expensive chemicals, moreover, the reported SW-AdASV on functionalized multiwall carbon nanotube modified carbon paste electrode dependes on in expensive materials, which was further functionalized.…”

Desenvolvimento de eletrodos de pasta de carbono a base de polidimetilsiloxano aplicados para a quantificação de propranolol em formulações farmacêuticas

“…Diferentes modificadores são utilizados para o preparo dos CMCPE empregados na determinação de fármacos em formulações farmacêuticas e fluídos biológicos. Dentre eles pode-se destacar: nanotubos de carbono de paredes múltiplas [46], nanopartículas de metais [47,48], zeólitas [49], óxido de grafeno [50], compostos inorgânicos [51], sílica funcionalizada [52], entre outros.…”