Improved cardiac function and dietary fatty acid metabolism after modest weight loss in subjects with impaired glucose tolerance

Labbé, Sébastien M.; Noll, Christophe; Grenier-Larouche, Thomas; Kunach, Margaret; Bouffard, Léandre; Phoenix, Serge; Guérin, Brigitte; Baillargeon, Jean-Patrice; Langlois, Marie‐France; Turcotte, Éric; Carpentier, André C.

doi:10.1152/ajpendo.00638.2013

Cited by 23 publications

(36 citation statements)

References 47 publications

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“…At time 260 min before meal intake, [ and electrocardiogram gating was performed, allowing the application of PET ventriculography to determine cardiac function, as previously published (14,15 (16), was mixed into Intralipid 20% (Baxter, Mississauga, Ontario, Canada), incorporated into gel capsules (T U B Enterprises), and given orally with the liquid meal. A dynamic list-mode PET scan centered on the thoracoabdominal segment was performed between time 90 and 120 min, and a whole-body PET/CT acquisition at time 360 min was performed as previously described (13).…”

Section: Experimental Protocolsmentioning

confidence: 99%

“…For dynamic PET acquisitions, myocardial and hepatic fractional DFA uptakes (K i ) were determined using Patlak linearization (17) as previously described (14,15). For whole-body scans, the mean value of pixels (mean standard uptake value [SUV]) for all tissues of interest was recorded (14,15).…”

Section: Pet/ct Image Analysesmentioning

confidence: 99%

“…For whole-body scans, the mean value of pixels (mean standard uptake value [SUV]) for all tissues of interest was recorded (14,15). Liver volume was extrapolated by drawing the liver surface on each 5 mm slice of the whole-body CT scan at time 360 min using OsiriX 5.8.2 software (Pixmeo SARL, Bernex, Switzerland).…”

Section: Pet/ct Image Analysesmentioning

confidence: 99%

“…For analysis of ventricular function, PET data from [ 11 C]-acetate images were analyzed as previously described (14,15).…”

Section: Pet/ct Image Analysesmentioning

confidence: 99%

“…Recently, using the noninvasive method of positron emission tomography (PET) imaging with the oral administration of 14(R,S)-[ acid analog (13), we have shown that subjects with impaired glucose tolerance (IGT) display an increase in myocardial DFA uptake and partitioning (defined as the relative biodistribution of DFA among all organs) that is associated with reduced left ventricular function (14). These metabolic and functional cardiac abnormalities were corrected after a 1-year lifestyle intervention with modest weight loss (15). As this lifestyle intervention included an individually tailored change in diet and physical activity, it was not possible to determine whether weight loss, change in insulin sensitivity, change in diet, or change in physical activity was responsible for correction of the cardiac DFA metabolic abnormalities.…”

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confidence: 99%

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Seven-Day Caloric and Saturated Fat Restriction Increases Myocardial Dietary Fatty Acid Partitioning in Impaired Glucose-Tolerant Subjects

et al. 2015

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Subjects with impaired glucose tolerance (IGT) have increased myocardial partitioning of dietary fatty acids (DFAs) with left ventricular dysfunction, both of which are improved by modest weight loss over 1 year induced by lifestyle changes. Here, we determined the effects of a 7-day hypocaloric diet (2500 kcal/day) low in saturated fat (<7% of energy) (LOWCAL study) versus isocaloric with the usual amount saturated fat (∼10% of energy) diet (ISOCAL) on DFA metabolism in subjects with IGT. Organ-specific DFA partitioning and cardiac and hepatic DFA fractional uptake rates were measured in 15 IGT subjects (7 males/8 females) using the oral 14(R,S)-[18 F]-fluoro-6-thia-heptadecanoic acid positron emission tomography method after 7 days of an ISOCAL diet versus a LOWCAL diet using a randomized crossover design. The LOWCAL diet led to reductions in weight and postprandial insulin area under the curve. Myocardial DFA partitioning over 6 h was increased after the LOWCAL diet (2.3 6 0.1 vs. 1.9 6 0.2 mean standard uptake value, P < 0.04). However, the early (90-120 min) myocardial DFA fractional uptake was unchanged after the LOWCAL diet (0.055 6 0.025 vs. 0.046 6 0.009 min 21, P = 0.7). Liver DFA partitioning was unchanged, but liver fractional uptake of DFA tended to be increased. Very short-term caloric and saturated fat dietary restrictions do not lead to the same changes in organ-specific DFA metabolism as those associated with weight loss in subjects with IGT.

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Section: Experimental Protocolsmentioning

confidence: 99%

Section: Pet/ct Image Analysesmentioning

confidence: 99%

Section: Pet/ct Image Analysesmentioning

confidence: 99%

“…For analysis of ventricular function, PET data from [ 11 C]-acetate images were analyzed as previously described (14,15).…”

Section: Pet/ct Image Analysesmentioning

confidence: 99%

mentioning

confidence: 99%

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Seven-Day Caloric and Saturated Fat Restriction Increases Myocardial Dietary Fatty Acid Partitioning in Impaired Glucose-Tolerant Subjects

et al. 2015

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Imaging of myocardial fatty acid oxidation

Mather

DeGrado

2016

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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Myocardial fuel selection is a key feature of the health and function of the heart, with clear links between myocardial function and fuel selection and important impacts of fuel selection on ischemia tolerance. Radiopharmaceuticals provide uniquely valuable tools for in vivo, non-invasive assessment of these aspects of cardiac function and metabolism. Here we review the landscape of imaging probes developed to provide noninvasive assessment of myocardial fatty acid oxidation (MFAO). Also, we review the state of current knowledge that myocardial fatty acid imaging has helped establish of static and dynamic fuel selection that characterizes cardiac and cardiometabolic disease and the interplay between fuel selection and various aspects of cardiac function.

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Abnormal Myocardial Dietary Fatty Acid Metabolism and Diabetic Cardiomyopathy

Carpentier

2018

Canadian Journal of Cardiology

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Improved cardiac function and dietary fatty acid metabolism after modest weight loss in subjects with impaired glucose tolerance

Abstract: Carpentier AC. Improved cardiac function and dietary fatty acid metabolism after modest weight loss in subjects with impaired glucose tolerance.

Cited by 23 publications

References 47 publications

Seven-Day Caloric and Saturated Fat Restriction Increases Myocardial Dietary Fatty Acid Partitioning in Impaired Glucose-Tolerant Subjects

Seven-Day Caloric and Saturated Fat Restriction Increases Myocardial Dietary Fatty Acid Partitioning in Impaired Glucose-Tolerant Subjects

Imaging of myocardial fatty acid oxidation

Abnormal Myocardial Dietary Fatty Acid Metabolism and Diabetic Cardiomyopathy

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