Abnormal Myocardial Dietary Fatty Acid Metabolism and Diabetic Cardiomyopathy

Carpentier, André C.

doi:10.1016/j.cjca.2017.12.029

Cited by 54 publications

(42 citation statements)

References 134 publications

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“…Increased plasma FFA are not only a hallmark of metabolic syndrome, dyslipidaemia and type 2 diabetes, but are also implicated in several ways in cardiomyopathy [ 128 ] and other diseases of the circulatory system. Several observations indicate their possible impact on plasma zinc speciation and export from plasma in the context of cardiovascular disease (or its diagnosis) and are described in the following sub-sections.…”

Section: Cardiovascular Disease and Haemostasismentioning

confidence: 99%

Crosstalk between zinc and free fatty acids in plasma

Coverdale

Khazaipoul

Arya

et al. 2019

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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In mammalian blood plasma, serum albumin acts as a transport protein for free fatty acids, other lipids and hydrophobic molecules including neurodegenerative peptides, and essential metal ions such as zinc to allow their systemic distribution. Importantly, binding of these chemically extremely diverse entities is not independent, but linked allosterically. One particularly intriguing allosteric link exists between free fatty acid and zinc binding. Albumin thus mediates crosstalk between energy status/metabolism and organismal zinc handling. In recognition of the fact that even small changes in extracellular zinc concentration and speciation modulate the function of many cell types, the albumin-mediated impact of free fatty acid concentration on zinc distribution may be significant for both normal physiological processes including energy metabolism, insulin activity, heparin neutralisation, blood coagulation, and zinc signalling, and a range of disease states, including metabolic syndrome, cardiovascular disease, myocardial ischemia, diabetes, and thrombosis.

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Section: Cardiovascular Disease and Haemostasismentioning

confidence: 99%

Crosstalk between zinc and free fatty acids in plasma

Coverdale

Khazaipoul

Arya

et al. 2019

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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“…Stearic and oleic acids also both increased clotting time and reduced the mechanical stability of the clot through a decreased rigidity, a higher deformability and a decreased internal resistance to shear stress [144]. In addition, plasma FFA levels also impact on the function of the heart as they increase its susceptibility to oxidative stress and ischemic damage [145]. Indeed, excess FFAs also lead to the formation of toxic lipids (in particular diacylglycerides and ceramide) thus promoting endoplasmic reticulum stress, mitochondrial dysfunction and the generation of reactive oxygen species [5].…”

Section: Changes In Lipid Metabolism At the Origin Of Atherosclerosismentioning

confidence: 99%

“…These toxic lipids also activate protein kinase C (PKC) [5]. PKC activation impairs intracellular Ca 2+ handling in the heart, affecting cardiac contractibility and promoting cardiac fibrosis and hypertrophy [145,146]. While n-3 unsaturated FFAs have been shown to have anti-arrhythmic and cardioprotective effects, saturated FFAs can lead to electrophysiological remodelling and sustained and fatal arrhythmias [147].…”

Section: Changes In Lipid Metabolism At the Origin Of Atherosclerosismentioning

confidence: 99%

Coagulatory Defects in Type-1 and Type-2 Diabetes

Sobczak

Stewart

2019

IJMS

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Diabetes (both type-1 and type-2) affects millions of individuals worldwide. A major cause of death for individuals with diabetes is cardiovascular diseases, in part since both types of diabetes lead to physiological changes that affect haemostasis. Those changes include altered concentrations of coagulatory proteins, hyper-activation of platelets, changes in metal ion homeostasis, alterations in lipid metabolism (leading to lipotoxicity in the heart and atherosclerosis), the presence of pro-coagulatory microparticles and endothelial dysfunction. In this review, we explore the different mechanisms by which diabetes leads to an increased risk of developing coagulatory disorders and how this differs between type-1 and type-2 diabetes.

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“…This systemic condition produces changes in the metabolism of cardiomyocytes, which increase their metabolism of fatty acids. 15 This leads to fibrosis and a loss of contractile properties, which decrease the compliance of the heart so cause diastolic dysfunction.…”

Section: Does Diabetic Cardiomyopathy Have a Simple Physiopathology?mentioning

confidence: 99%

Diabetic Cardiomyopathy: Five Major Questions with Simple Answers

Rodríguez-Ramos

2019

US Cardiology Review

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Diabetes is a major risk factor for heart disease. Diabetic cardiomyopathy is a long-lasting process that affects the myocardium in patients who have no other cardiac conditions. The condition has a complex physiopathology which can be subdivided into processes that cause diastolic and/or systolic dysfunction. It is believed to be more common than reported, but this has not been confirmed by a large study. Diagnosis can involve imaging; biomarkers cannot be used to identify diabetic cardiomyopathy at an early stage. In people with diabetes, there should be a focus on prevention and, if diabetic cardiomyopathy develops, the objective is to delay disease progression. Further studies into identifying and managing diabetic cardiomyopathy are essential to reduce the risk of heart failure in people with diabetes.

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Abnormal Myocardial Dietary Fatty Acid Metabolism and Diabetic Cardiomyopathy

Cited by 54 publications

References 134 publications

Crosstalk between zinc and free fatty acids in plasma

Crosstalk between zinc and free fatty acids in plasma

Coagulatory Defects in Type-1 and Type-2 Diabetes

Diabetic Cardiomyopathy: Five Major Questions with Simple Answers

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