2015
DOI: 10.1016/j.actbio.2015.07.043
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Improved burn wound healing by the antimicrobial peptide LLKKK18 released from conjugates with dextrin embedded in a carbopol gel

Abstract: This work presents a newly developed formulation that holds great potential as a therapeutic approach for burn treatment. It is based on the sustained delivery of an antimicrobial peptide - LLKKK18 - from conjugates with dextrin, after degradation of dextrin backbone upon exposure to wound α-amylases. Conjugates were further embedded in Carbopol®, a commercially available hydrogel, suitable for topical administration and that provides a moist environment to the wound. Overall, we obtained an efficient, safe an… Show more

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Cited by 70 publications
(58 citation statements)
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“…Wound healing may have occurred because of the regulation of collagen expression23 and an increase in the tensile strength of the wounds24. Healing activity depends on collagen formation and angiogenesis25.…”
Section: Discussionmentioning
confidence: 99%
“…Wound healing may have occurred because of the regulation of collagen expression23 and an increase in the tensile strength of the wounds24. Healing activity depends on collagen formation and angiogenesis25.…”
Section: Discussionmentioning
confidence: 99%
“…Burn injuries give rise to complex wounds and may be life threatening to third‐degree burn patients . More than 100 million people are affected by burn injuries every year worldwide according to the World Health Organization (WHO) . If not treated timely, wound necrosis progresses toward nearby tissue and lead to fatal consequences .…”
Section: Introductionmentioning
confidence: 99%
“…[16,17] It has been used in drug delivery systems for buccal, transdermal, [18] ocular, rectal, vaginal, [19] nasal [20] and wound dressing applications. [21] 2 Experimental…”
Section: Introductionmentioning
confidence: 99%