Improved bone ingrowth of tricalcium phosphate filled Poly(methyl methacrylate) (PMMA) bone cements in vivo

Gao, Shan; Lv, Yang; Yuan, Leilei; Ren, Hongyan; Wu, Teng; Liu, Bingchuan; Zhang, Yawen; Zhou, Rubing; Li, Ailing; Zhou, Fang

doi:10.1016/j.polymertesting.2019.02.015

Cited by 21 publications

(11 citation statements)

References 37 publications

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“…Different factors are important for the mechanical properties of nanomaterials, as nanoparticle selection, production process, grain size, and grain boundary structure [ 55 ]. By introducing nanostructured titania fibers at 1 wt.% into the cement matrix, with the fibers acting as a reinforcing phase, an increase in resistance to brittle cracking and flexural mechanical strength was substantially improved [ 56 ]. The use of hydroxyethyl methacrylate (HEMA) for improving the affinity of TCP/PMMA blends system significantly increased the mechanical properties [ 57 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Different Nanometals Implemented in PMMA Bone Cement on Biological and Mechanical Properties

et al. 2022

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Cemented arthroplasty is a common process to fix prostheses when a patient becomes older and his/her bone quality deteriorates. The applied cements are biocompatible, can transfer loads, and dampen vibrations, but do not provide antibacterial protection. The present work is aimed at the development of cement with antibacterial effectivity achieved with the implementation of nanoparticles of different metals. The powders of Ag, Cu with particles size in a range of 10–30 nm (Cu10) and 70–100 nm (Cu70), AgCu, and Ni were added to PMMA cement. Their influence on compression strength, wettability, and antibacterial properties of cement was assessed. The surface topography of samples was examined with biological and scanning electron microscopy. The mechanical properties were determined by compression tests. A contact angle was observed with a goniometer. The biological tests included an assessment of cytotoxicity (XTT test on human cells Saos-2 line) and bacteria viability exposure (6 months). The cements with Ag and Cu nanopowders were free of bacteria. For AgCu and Ni nanoparticles, the bacterial solution became denser over time and, after 6 months, the bacteria clustered into conglomerates, creating a biofilm. All metal powders in their native form in direct contact reduce the number of eukaryotic cells. Cell viability is the least limited by Ag and Cu particles of smaller size. All samples demonstrated hydrophobic nature in the wettability test. The mechanical strength was not significantly affected by the additions of metal powders. The nanometal particles incorporated in PMMA-based bone cement can introduce long-term resistance against bacteria, not resulting in any serious deterioration of compression strength.

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Section: Introductionmentioning

confidence: 99%

Influence of Different Nanometals Implemented in PMMA Bone Cement on Biological and Mechanical Properties

et al. 2022

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“…The extracts of cements were prepared according to the ISO10993 standard. [70,71] In brief, the aforementioned sterilized cement discs were incubated in MEM medium (cement sample to medium ratio: 0.2 g mL −1 ) at 37 °C for 24 h. Meanwhile, cells were seeded into a 96-well plate at a density of 8 × 10 3 cells mL −1 and 100 µL growth medium per well. After being incubated for 24 h at 37 °C/5% CO 2 , the medium solution was removed and replaced with 100 µL of the cement extracts in each well.…”

Section: Methodsmentioning

confidence: 99%

Bone Tumor Suppression in Rabbits by Hyperthermia below the Clinical Safety Limit Using Aligned Magnetic Bone Cement

Gao

et al. 2021

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composition [14,19] of MNPs. For example, we obtained an SLP of 3417 W metal g 1 − at a field of 33 kA m −1 and 380 kHz in Co 0.03 Mn 0.27 Fe 2.7 O 4 /SiO 2 MNPs. [14] In recent years, great progress has been made on in vivo magnetic hyperthermia treatments of solid tumors. [20][21][22][23][24][25][26][27] It was reported that tumors in mice can be eliminated after receiving magnetic hyperthermia treatment using coreshell MNPs. [6] Systemically delivered ZnMn-ferrite MNPs were shown to have increased the intratumoral temperature to above 42 °C in mice, which significantly inhibited prostate cancer growth. [28] More recently, studies also focused on heat-triggered drug release and highly efficient heat-induced immunotherapy instead of using heating alone. [20,24,29] In addition to injected or delivered MNPs, magnetic composite implants and magnetic scaffolds were also used for local hyperthermia. [30][31][32][33][34][35][36][37] The first magnetic hyperthermia was attempted in 1957 for metastasis in lymph nodes. [1] In 2005, the first clinical application of interstitial hyperthermia using MNPs in locally recurrent prostate cancer was reported. [38] Maier-Hauff et al. published results from a Phase I clinical study involving 14 patients with recurrent glioblastoma multiforme. [39,40] These clinical studies were performed using a commercial machine (Mag-Force MFH 300F). A roadmap for magnetic hyperthermia Demonstrating highly efficient alternating current (AC) magnetic field heating of nanoparticles in physiological environments under clinically safe field parameters has remained a great challenge, hindering clinical applications of magnetic hyperthermia. In this work, exceptionally high loss power of magnetic bone cement under the clinical safety limit of AC field parameters, incorporating direct current field-aligned soft magnetic Zn 0.3 Fe 2.7 O 4 nanoparticles with low concentration, is reported. Under an AC field of 4 kA m −1 at 430 kHz, the aligned bone cement with 0.2 wt% nanoparticles achieves a temperature increase of 30 °C in 180 s. This amounts to a specific loss power value of 327 W g g 1 1 m me et ta al l − − and an intrinsic loss power of 47 nHm 2 kg −1 , which is enhanced by 50-fold compared to randomly oriented samples. The highperformance magnetic bone cement allows for the demonstration of effective hyperthermia suppression of tumor growth in the bone marrow cavity of New Zealand White Rabbits subjected to rapid cooling due to blood circulation, and significant enhancement of survival rate.

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“…In this context, a number of synthetic and natural materials, such as polymers including CS and poly( ε ‐caprolactone), have already been suggested and produced as bone substitutes and fillers 157–169 . Various types of BG particles such as 45S5 Bioglass have been embedded in bone adhesives to enhance cell ingrowth which is critical for clinical applications 170–172 .…”

Section: Composite‐based Bcsmentioning

confidence: 99%

Poly(methyl methacrylate) bone cement, its rise, growth, downfall and future

Bakhtiari

Bakhsheshi-Rad

Karbasi

et al. 2020

Polymer International

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Poly(methyl methacrylate) (PMMA)‐based bone cements (BCs) can be defined as a family of materials that consist of powder and liquid phases which after mixing form a plastic paste that can self‐set once implanted in the human body. PMMA‐based BCs are easily molded and adapted to complex bone cavities or used in orthodontic applications to restore dental damage. The main advantages of the use of cement are the excellent primary fixation between bone and implant and, therefore, the faster recovery of the patient. Despite the initial success rate of implant fixation with BCs, they have some disadvantages such as local tissue damage due to exothermic polymerization reactions, mechanical mismatch between native bone and cement, lack of bone regeneration and bioactivity and poor mechanical properties which may cause the failure of the BCs. BCs are still considered as a top option for bone repair. Due to the disadvantages highlighted, research has focused on alternative materials used with PMMA‐based BCs. This review aims to critically review the BCs and emerging materials used in combination with PMMA‐based BCs. These materials include titania, apatite–wollastonite (A‐W), glass ceramic (GC) and hydroxyapatite (HA). The review discusses the properties of these materials and their pathway to clinical study. Among the various kinds of reinforcement, HA has been extensively used. So, in this review, we compare the effects of HA as reinforcement in PMMA‐based BCs. Upcoming study of PMMA‐based BCs should concentrate on trialing combinations of these reinforcing agents as this might improve beneficial characteristics. © 2020 Society of Industrial Chemistry

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Improved bone ingrowth of tricalcium phosphate filled Poly(methyl methacrylate) (PMMA) bone cements in vivo

Cited by 21 publications

References 37 publications

Influence of Different Nanometals Implemented in PMMA Bone Cement on Biological and Mechanical Properties

Influence of Different Nanometals Implemented in PMMA Bone Cement on Biological and Mechanical Properties

Bone Tumor Suppression in Rabbits by Hyperthermia below the Clinical Safety Limit Using Aligned Magnetic Bone Cement

Poly(methyl methacrylate) bone cement, its rise, growth, downfall and future

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