Imposed hydrophobic interactions by NaCl: accountable attribute for the synthesis of spiro[acenaphthylene-1,5′-pyrrolo[1,2-c]thiazole] derivatives via 1,3-dipolar cycloaddition reaction in aqueous medium

Abstract

The significance of hydrophobicity for the synthesis of spiro[acenaphthylene-1,5′-pyrrolo[1,2-c]thiazole] derivatives by a 1,3-dipolar cycloaddition reaction in aqueous medium is outlined.

Chemical Waltz of Organic Molecules “On Water”: Saline-Assisted Sustainable Regioselective Synthesis of Fluorogenic Heterobioconjugates via Click Reaction

“…These kosmotropes capture the hydrophobic reactant molecules inside the cavity and thus decrease the interaction of reactant molecules. 43−45 Therefore, the reaction cannot be carried out in water alone. Compounds like NaCl act as a “salting-out” agent, which increases the hydrophobic effect and thus disturbs the kosmotropes by increasing the cavity formation energy cost in aqueous solution.…”

Rapid and Efficient Uncatalyzed Knoevenagel Condensations from Binary Mixture of Ethanol and Water

“…The reactions with heteroaromatic aldehydes (entries 20,22) finished in a short time. As the n-pyridinecarboxyaldehydes (n = 3 or 4, entries 20, 21) are rather reactive electrophiles and are completely miscible in water, the reactions with these substrates were incredibly fast (in seconds).…”

“…In the earliest works, the amines used to catalyze the reactions presented a considerable level of toxicity. 16,17 Thus, many papers have been published in recent years concerning proposals for ecofriendly reaction conditions, [18][19][20][21][22] in accordance with the principles of green chemistry. [22][23][24][25] From this perspective, many researchers have developed new catalysts involving the mentioned principles.…”

Graphene oxide‐catalyzed CSp3–H activation of methylarenes in aqueous medium: A unified metal‐free access to amides and benzimidazoles

“…Thus, in extension of our work and in view of this, we demonstrate the metal‐free oxidative coupling of unreactive reactant partner methylarenes and anilines for the formation of amide bonds using GO nanosheets in the presence of TBHP as a co‐oxidant under aqueous medium at room temperature (Scheme ). We have found that the carboxylic acid functional groups on GO nanosheets play a vital role in this metal‐free strategy.…”