Imported fire ant field reaction and immunotherapy safety characteristics: The IFACS study

Shell, Mark S. La; Calabria, Christopher W.; Quinn, James A.

doi:10.1016/j.jaci.2010.02.041

Cited by 34 publications

(18 citation statements)

References 35 publications

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“…218 Prospective studies investigating the sensitivity and specificity of LLRs and the effect of immunotherapy protocol modifications based on them are needed.…”

Section: Safety Of Immunotherapy Local Reactionsmentioning

confidence: 99%

Allergen immunotherapy: A practice parameter third update

Cox

Nelson

Lockey

et al. 2011

Journal of Allergy and Clinical Immunology

1,005

1,054

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“…218 Prospective studies investigating the sensitivity and specificity of LLRs and the effect of immunotherapy protocol modifications based on them are needed.…”

Section: Safety Of Immunotherapy Local Reactionsmentioning

confidence: 99%

Allergen immunotherapy: A practice parameter third update

Cox

Nelson

Lockey

et al. 2011

Journal of Allergy and Clinical Immunology

1,005

1,054

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“…It was supposed that SARs are mainly elicited by multiple stings. Recently, it was shown that the majority of SARs already occurred after only one sting [35 ]. For the treatment of ant venom allergy, only whole-body extracts are available.…”

Section: Venom For Specific Immunotherapymentioning

confidence: 99%

Management of occupational Hymenoptera allergy

Ruëff

Châtelain

Przybilla

2011

Current Opinion in Allergy &Amp; Clinical Immunology

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If an intensely exposed patient presents with a systemic anaphylactic sting reaction, efficacy of venom immunotherapy should be demonstrated by a tolerated sting challenge before allowing this patient to return to his/her occupation. Patients with bee venom allergy and an intense exposure should be treated with an increased maintenance dose of 200 μg bee venom. Patients with a history of large local reactions should be provided with an emergency kit, which should contain oral antihistamines and corticosteroids. In patients in whom local sting reactions induce symptoms of high clinical significance, an off-label use of venom immunotherapy may be discussed.

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“…For patients with anaphylactic reactions to Hymenoptera venom, or patients who cannot avoid future exposures, the only causative treatment which reduces the risk of subsequent systemic reactions is venom immunotherapy (VIT) with a protection rate ranging from 75 to 98%, being the only mode of immunotherapy currently approved is subcutaneous (SCIT). The IFACS study demonstrated that IFA SCIT is safe and that SRs that do occur tend to be mild [17,18].…”

Section: Discussionmentioning

confidence: 99%