Importance of the surface area ratio on cytokines production by human monocytes in vitro induced by various hydroxyapatite particles

Grandjean-Laquerriere, Alexia; Laquerrière, Patrice; Guenounou, Moncef; Laurent-Maquin, Dominique; Phillips, Terry M.

doi:10.1016/j.biomaterials.2004.07.036

Cited by 64 publications

(54 citation statements)

References 21 publications

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“…This feature was confirmed by the result of the nitrogen adsorption method ( Table 1) that revealed that Osteobiol® particles, though larger, possess a much larger specific surface area than those of Bonelike® (about 15 fold), which appears to be also an advantage in terms biological response [46].…”

Section: Accepted M Manuscriptmentioning

confidence: 55%

Comparison of a xenogeneic and an alloplastic material used in dental implants in terms of physico-chemical characteristics and in vivo inflammatory response

Figueiredo

Coimbra

Cabrita

et al. 2013

Materials Science and Engineering: C

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Two commercial bone grafts used in dentistry (Osteobiol Gen-Os®, a xenograft of porcine origin, and Bonelike®, a hydroxyapatite based synthetic material), in the form of granules, were characterized and evaluated in vivo regarding the intensity of the tissue inflammatory response. These biomaterials were characterized in terms of morphology, particle size distribution, porosity and pore size, specific surface are and density. The chemical composition and structure of the materials were accessed by Fourier-Transform Infrared Spectroscopy (FTIR) and X-ray Diffraction (XRD). The graft materials were implanted in the gluteus maximus muscles of Wistar rats and the inflammatory response evaluated through histological analysis, after one week of implantation.The results showed that the two grafts have quite different characteristics in practically all the evaluated properties. While Osteobiol® exhibits a structure and composition similar to the natural bone, Bonelike® is constituted by a main crystalline phase of hydroxyapatite and two secondary phases of -and -tricalcium phosphate. Osteobiol® granules, besides being larger, are irregular, and exhibit sharp-edged tips, while those of Bonelike® are approximately cylindrical, with round contours, and more uniform in size. The in vivo response evaluated from the inflammatory infiltrates revealed that although both implants did not cause severe inflammation, Bonelike® granules elicit a consistently more intense inflammatory reaction than that triggered by the granules of Osteobiol®, particularly in terms of collagen production and formation of fibrous capsule. This reaction was partly explained in terms of the characteristics evaluated for the granules of this material.

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Section: Accepted M Manuscriptmentioning

confidence: 55%

Comparison of a xenogeneic and an alloplastic material used in dental implants in terms of physico-chemical characteristics and in vivo inflammatory response

Figueiredo

Coimbra

Cabrita

et al. 2013

Materials Science and Engineering: C

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“…These authors concluded that macrophages infiltrating the sites of lipid accumulation secrete cytokines that induce the phenotypic differentiation of VSMCs into functional osteoblast-like cells. Given that calcium phosphate displays pro-inflammatory properties (75)(76)(77), Shanahan (78) suggested that these processes may lead to a vicious cycle of inflammation and calcification, which would eventually propitiate atherosclero- sis. We recently found that mineralo-organic NPs of calcium phosphate do not activate pro-inflammatory reactions in macrophages but that large particle aggregates led to caspase-1 activation and secretion of pro-inflammatory IL-1␤ (17).…”

Section: Discussionmentioning

confidence: 99%

Membrane Vesicles Nucleate Mineralo-organic Nanoparticles and Induce Carbonate Apatite Precipitation in Human Body Fluids

Martel

Cheng

et al. 2013

Journal of Biological Chemistry

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Background: Membrane vesicles (MVs) released from various cells are associated with human diseases. Results: MVs isolated from human serum induce the formation of mineralo-organic nanoparticles in culture. Conclusion: MVs represent a nucleating factor that promotes the formation of mineralo-organic nanoparticles and the precipitation of mineral deposits in body fluids. Significance: The ectopic precipitation of carbonate apatite deposits in body fluids and tissues may be initiated in part by MVs.

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“…Needle-shaped microparticles have been found to induce the highest production of inflammatory cytokines [77][78][79]. Cai et al [75] reported that the cytotoxic effect of n-HA on MSCs was dependent on their size and ζ potential values.…”

Section: Biological Propertiesmentioning

confidence: 99%

Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

Yousefi

Oudadesse

Akbarzadeh

et al. 2014

Nanotechnology Reviews

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Critical-sized bone defects have, in many cases, posed challenges to the current gold standard treatments. Bioactive glasses are reported to be able to stimulate more bone regeneration than other bioactive ceramics; however, the difficulty in producing porous scaffolds made of bioactive glasses has limited their extensive use in bone regeneration. On the other hand, calcium phosphate ceramics such as synthetic hydroxyapatite and tricalcium phosphate are widely used in the clinic, but they stimulate less bone regeneration. This paper gives an overview of the recent developments in the field of bioactive nanoparticles, with a focus on nanohydroxyapatite and bioactive glasses for bone repair and regeneration. First, a brief overview of the chemical structure and common methods used to produce synthetic nanohydroxyapatite and bioactive glasses has been presented. The main body of the paper covers the physical and biological properties of these biomaterials, as well as their composites with biodegradable polymers used in bone regeneration. A summary of existing challenges and some recommendations for future directions have been brought in the concluding section of this paper.

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Importance of the surface area ratio on cytokines production by human monocytes in vitro induced by various hydroxyapatite particles

Cited by 64 publications

References 21 publications

Comparison of a xenogeneic and an alloplastic material used in dental implants in terms of physico-chemical characteristics and in vivo inflammatory response

Comparison of a xenogeneic and an alloplastic material used in dental implants in terms of physico-chemical characteristics and in vivo inflammatory response

Membrane Vesicles Nucleate Mineralo-organic Nanoparticles and Induce Carbonate Apatite Precipitation in Human Body Fluids

Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

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