Importance of Drava Sveda: A Review

Sahu, Lalravi; Sinha, K. P.; M, Ashvini Kumar; Ba, Lohith

doi:10.7897/2277-4343.085265

Cited by 2 publications

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“…However, there are only a handful of studies 48 49 50 51 52 53 focusing on the functioning of otolith organs and semicircular canals (SCCs) in DM2 individuals. Ocular and cervical vestibular-evoked myogenic potentials (o-VEMPs and c-VEMPs) are known to assess the functioning of the otolith organs.The video head impulse test (vHIT) can assess the SCCs in all the three different planes.…”

Section: Resultsmentioning

confidence: 99%

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Auditory and Vestibular Functioning in Individuals with Type-2 Diabetes Mellitus: A Systematic Review

Kumar

Singh

Apeksha

et al. 2021

Int Arch Otorhinolaryngol

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Introduction Diabetes mellitus is a metabolic disease associated with a rise in the level of blood glucose. Individuals with diabetes mellitus are more likely to develop hearing loss, tinnitus, and dizziness due to macro- and microvascular complications. The extent to which auditory and vestibular functions are impaired in individuals with type-2 diabetes mellitus is still under debate. Objective To systematically review studies focusing on auditory and vestibular functions in individuals with type-2 diabetes mellitus. Data Synthesis A search was conducted in the PubMed, MedlinePlus, Ingenta Connect and Google Scholar databases for articles published until June 2019. A total of 15,980 articles were primarily retrieved, 33 of which were shortlisted based on the inclusion criteria set by the investigators for the systematic review. Out of 33 full-length articles, 26 evaluated the functioning of the auditory system, while 7 evaluated the functioning of the vestibular system. Most studies related to auditory functioning reported a significant effect of type-2 diabetes mellitus on the peripheral auditory system, whereas studies on vestibular functioning reported no significant effect of diabetes mellitus on the functioning of the peripheral vestibular end-organ. Conclusion Overall, the results of various audiological and peripheral vestibular tests reveal distinctive peripheral and/or central auditory and vestibular end-organ impairments in individuals with type-2 diabetes mellitus.

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Section: Resultsmentioning

confidence: 99%

“…49 Similarly, reduced amplitudes in both c-VEMPs and o-VEMPs were observed in DM2 individuals. 50 Vestibular dysfunctions in DM2 individuals could be aconsequence of sensory or motor polyneuropathy. 49…”

Section: Resultsmentioning

confidence: 99%

Auditory and Vestibular Functioning in Individuals with Type-2 Diabetes Mellitus: A Systematic Review

Kumar

Singh

Apeksha

et al. 2021

Int Arch Otorhinolaryngol

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“…Owing to the problems associated with existing chemotherapies, there is an urgent need to discover and develop novel antileishmanial drugs. In this context, six‐membered aromatic heterocycles containing nitrogen, such as pyridine and pyrazine, have received attention from the scientific community due to their broad spectrum of biological activities, including antineoplastic, antibacterial, antifungal, anticonvulsant, antiviral, and anti‐inflammatory. The aim of this work was to synthesize and evaluate the biological activity and mechanism of action of 2‐pyrazyl and 2‐pyridylhydrazone derivatives, new classes of antileishmanial agents.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Biological Activity, and Mechanism of Action of 2‐Pyrazyl and Pyridylhydrazone Derivatives, New Classes of Antileishmanial Agents

et al. 2018

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In this work, we report the antileishmanial activity of 23 compounds based on 2-pyrazyl and 2-pyridylhydrazone derivatives. The compounds were tested against the promastigotes of Leishmania amazonensis and L. braziliensis, murine macrophages, and intracellular L. amazonensis amastigotes. The most potent antileishmanial compound was selected for investigation into its mechanism of action. Among the evaluated compounds, five derivatives [(E)-3-((2-(pyridin-2-yl)hydrazono)methyl)benzene-1,2-diol (2 b), (E)-4-((2-(pyridin-2-yl)hydrazono)methyl)benzene-1,3-diol (2 c), (E)-4-nitro-2-((2-(pyrazin-2-yl)hydrazono)methyl)phenol (2 s), (E)-2-(2-(pyridin-2-ylmethylene)hydrazinyl)pyrazine (2 u), and (E)-2-(2-((5-nitrofuran-2-yl)methylene)hydrazinyl)pyrazine (2 v)] exhibited significant activity against L. amazonensis amastigote forms, with IC values below 20 μm. The majority of the compounds did not show any toxic effect on murine macrophages. Preliminary studies on the mode of action of members of this hydrazine-derived series indicate that the accumulation of reactive oxygen species (ROS) and disruption of parasite mitochondrial function are important for the pharmacological effect on L. amazonensis promastigotes.

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Importance of Drava Sveda: A Review

Cited by 2 publications

References 0 publications

Auditory and Vestibular Functioning in Individuals with Type-2 Diabetes Mellitus: A Systematic Review

Auditory and Vestibular Functioning in Individuals with Type-2 Diabetes Mellitus: A Systematic Review

Synthesis, Biological Activity, and Mechanism of Action of 2‐Pyrazyl and Pyridylhydrazone Derivatives, New Classes of Antileishmanial Agents

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