Implicaciones de las poliaminas en la salud infantil

Ruiz-Cano, Domingo; Pérez‐Llamas, Francisca; Zamora, Salvador

doi:10.5546/aap.2012.244

Cited by 9 publications

(14 citation statements)

References 52 publications

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“…On the other hand, polyamines can also be found in food of both animal and plant origin. An important source of polyamines for humans is breast milk and infant formula (2, 4).…”

Section: Introductionmentioning

confidence: 99%

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Polyamines in Food

et al. 2019

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The polyamines spermine, spermidine, and putrescine are involved in various biological processes, notably in cell proliferation and differentiation, and also have antioxidant properties. Dietary polyamines have important implications in human health, mainly in the intestinal maturation and in the differentiation and development of immune system. The antioxidant and anti-inflammatory effect of polyamine can also play an important role in the prevention of chronic diseases such as cardiovascular diseases. In addition to endogenous synthesis, food is an important source of polyamines. Although there are no recommendations for polyamine daily intake, it is known that in stages of rapid cell growth (i.e., in the neonatal period), polyamine requirements are high. Additionally, de novo synthesis of polyamines tends to decrease with age, which is why their dietary sources acquire a greater importance in an aging population. Polyamine daily intake differs among to the available estimations, probably due to different dietary patterns and methodologies of data collection. Polyamines can be found in all types of foods in a wide range of concentrations. Spermidine and spermine are naturally present in food whereas putrescine could also have a microbial origin. The main polyamine in plant-based products is spermidine, whereas spermine content is generally higher in animal-derived foods. This article reviews the main implications of polyamines for human health, as well as their content in food and breast milk and infant formula. In addition, the estimated levels of polyamines intake in different populations are provided.

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“…On the other hand, polyamines can also be found in food of both animal and plant origin. An important source of polyamines for humans is breast milk and infant formula (2, 4).…”

Section: Introductionmentioning

confidence: 99%

“…Polyamines play an essential role in cell growth and proliferation, the stabilization of negative charges of DNA, RNA transcription, protein synthesis, the regulation of the immune response, apoptosis, the regulation of ion channels, particularly by blocking potassium channels, and as antioxidants (2, 4, 5, 7, 9–12).…”

Section: Introductionmentioning

confidence: 99%

Polyamines in Food

et al. 2019

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“…It has been claimed that polyamines influence the development and differentiation of cells (16,27). It is known that at low doses, polyamines cause colon cancer to advance (28).…”

Section: Discussionmentioning

confidence: 99%

“…It is thought that putrescine plays a role in the growth and differentiation of cells. It can be considered to be a storage location for amine in the body (16,17). It has been claimed that it can cause cell growth because it stores amine, but that nitrous oxide derivatives synthesized from amine can cause damage to cells.…”

Section: Introductionmentioning

confidence: 99%

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The protective effects of cysteamine, putrescine, and the combination of cysteamineand putrescine on fibrosarcoma induced in mice with 3-methylcholanthrene

Doğan¹,

Aksu²,

Erdağ³

et al. 2016

Turk J Vet Anim Sci

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In this study, the protective effects of cysteamine, putrescine, and the combination of cysteamine and putrescine were investigated in mice with fibrosarcoma induced with 3-methylcholanthrene (3-MC). A total of 135 adult male albino mice (Mus musculus), 2-3 months old and weighing 20 ± 2.0 g, were used in this study. All groups (each consisting of 15 mice) were fed ad libitum. The experimental groups were Group 1 (drinking water), Group 2 (0.2 mL sesame oil s.c.), Group 3 (1 mg 3-MC/0.2 mL sesame oil), Group 4 (0.1% cysteamine), Group 5 (0.1% putrescine), Group 6 (0.1% cysteamine + putrescine), Group 7 (1 mg 3-MC/0.2 sesame oil + 0.1% cysteamine), Group 8 (1 mg 3-MC/0.2 mL sesame oil + 0.1% putrescine), and Group 9 (1 mg 3-MC/0.2 mL sesame oil + 0.1% cysteamine + 0.1% putrescine). Experimental groups were given cysteamine and/or putrescine mixed with drinking water right after being injected with 3-MC subcutaneously. After 7 months, the mice were euthanized by means of cervical dislocation and were evaluated morphologically and histopathologically. The results showed that the number of tumors of 3-MC-induced fibrosarcoma were reduced from the highest to the lowest by cysteamine, cysteamine + putrescine, and putrescine, respectively.

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