Implementation of the European multicentre database of healthy controls for [123I]FP-CIT SPECT increases diagnostic accuracy in patients with clinically uncertain parkinsonian syndromes

Albert, Nathalie L.; Diemling, Markus; Xiong, Guoming; Bartenstein, Peter; Koch, Walter; Varrone, Andrea; Dickson, John; Tossici-Bolt, Livia; Séra, Teréz; Asenbaum, S.; Booij, Jan; Atay, Lütfiye Özlem; Kluge, Andreas; Ziebell, Morten; Darcourt, Jacques; Nobili, Flavio; Pagani, Marco; Sabri, Osama; Hesse, Swen; Laere, Koen Van; Tatsch, Klaus; Fougère, Christian la

doi:10.1007/s00259-015-3304-2

Cited by 29 publications

(25 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The values of sensitivity and specificity given in this paper are lower than that normally reported for [ 123 I]FP-CIT SPECT [3]. This is a likely reflection of the cohort of patients included in this study that were mixed in nature, including typical and atypical parkinsonian syndromes, and patients with Lewy body dementia.…”

Section: Discussioncontrasting

confidence: 56%

See 1 more Smart Citation

The impact of reconstruction and scanner characterisation on the diagnostic capability of a normal database for [123I]FP-CIT SPECT imaging

et al. 2017

Self Cite

View full text Add to dashboard Cite

BackgroundThe use of a normal database for [123I]FP-CIT SPECT imaging has been found to be helpful for cases which are difficult to interpret by visual assessment alone, and to improve reproducibility in scan interpretation. The aim of this study was to assess whether the use of different tomographic reconstructions affects the performance of a normal [123I]FP-CIT SPECT database and also whether systems benefit from a system characterisation before a database is used.Seventy-seven [123I]FP-CIT SPECT studies from two sites and with 3-year clinical follow-up were assessed quantitatively for scan normality using the ENC-DAT normal database obtained in well-documented healthy subjects. Patient and normal data were reconstructed with iterative reconstruction with correction for attenuation, scatter and septal penetration (ACSC), the same reconstruction without corrections (IRNC), and filtered back-projection (FBP) with data quantified using small volume-of-interest (VOI) (BRASS) and large VOI (Southampton) analysis methods. Test performance was assessed with and without system characterisation, using receiver operating characteristics (ROC) analysis for age-independent data and using sensitivity/specificity analysis with age-matched normal values. The clinical diagnosis at follow-up was used as the standard of truth.ResultsThere were no significant differences in the age-independent quantitative assessment of scan normality across reconstructions, system characterisation and quantitative methods (ROC AUC 0.866–0.924). With BRASS quantification, there were no significant differences between the values of sensitivity (67.4–83.7%) or specificity (79.4–91.2%) across all reconstruction and calibration strategies. However, the Southampton method showed significant differences in sensitivity between ACSC (90.7%) vs IRNC (76.7%) and FBP (67.4%) reconstructions with calibration. Sensitivity using ACSC reconstruction with this method was also significantly better with calibration than without calibration (65.1%). Specificity using the Southampton method was unchanged across reconstruction and calibration choices (82.4–88.2%).ConclusionsThe ability of a normal [123I]FP-CIT SPECT database to assess clinical scan normality is equivalent across all reconstruction, system characterisation, and quantification strategies using BRASS quantification. However, when using the Southampton quantification method, performance is sensitive to the reconstruction and calibration strategy used.

show abstract

Section: Discussioncontrasting

confidence: 56%

“…In a substantial number of studies, visual assessment is adequate to accurately interpret images; however, with difficult to interpret cases, quantification of striatal tracer binding can be beneficial in coming to a more confident interpretation of the scan [3, 4] or to increase confidence in less-experienced readers [5]. …”

Section: Introductionmentioning

confidence: 99%

The impact of reconstruction and scanner characterisation on the diagnostic capability of a normal database for [123I]FP-CIT SPECT imaging

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…SPECT imaging using [ 123 I]FP-CIT is routinely assessed via visual interpretation by an expert reader in clinical studies. However, in difficult-to-interpret cases, quantification of striatal DAT binding helps clinicians to reach a more confident interpretation of the scan [3] or helps to increase confidence in less-experienced readers [4]. Whether a SPECT scan is considered normal or abnormal sometimes relies on a comparison of individual values to a reference database obtained in healthy controls.…”

Section: Introductionmentioning

confidence: 99%

Japanese multicenter database of healthy controls for [123I]FP-CIT SPECT

Matsuda

Murata

Mukai

et al. 2018

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

PurposeThe aim of this multicenter trial was to generate a [123I]FP-CIT SPECT database of healthy controls from the common SPECT systems available in Japan.MethodsThis study included 510 sets of SPECT data from 256 healthy controls (116 men and 140 women; age range, 30–83 years) acquired from eight different centers. Images were reconstructed without attenuation or scatter correction (NOACNOSC), with only attenuation correction using the Chang method (ChangACNOSC) or X-ray CT (CTACNOSC), and with both scatter and attenuation correction using the Chang method (ChangACSC) or X-ray CT (CTACSC). These SPECT images were analyzed using the Southampton method. The outcome measure was the specific binding ratio (SBR) in the striatum. These striatal SBRs were calibrated from prior experiments using a striatal phantom.ResultsThe original SBRs gradually decreased in the order of ChangACSC, CTACSC, ChangACNOSC, CTACNOSC, and NOACNOSC. The SBRs for NOACNOSC were 46% lower than those for ChangACSC. In contrast, the calibrated SBRs were almost equal under no scatter correction (NOSC) conditions. A significant effect of age was found, with an SBR decline rate of 6.3% per decade. In the 30–39 age group, SBRs were 12.2% higher in women than in men, but this increase declined with age and was absent in the 70–79 age group.ConclusionsThis study provided a large-scale quantitative database of [123I]FP-CIT SPECT scans from different scanners in healthy controls across a wide age range and with balanced sex representation. The phantom calibration effectively harmonizes SPECT data from different SPECT systems under NOSC conditions. The data collected in this study may serve as a reference database. Electronic supplementary materialThe online version of this article (10.1007/s00259-018-3976-5) contains supplementary material, which is available to authorized users.

show abstract

“…12 Dopaminergic deficiency in PD is illustrated by asymmetric reduced uptake of the radiotracer [ 123 I]-FP-CIT in the striatum. 13 Reduced uptake is most notable contralateral to the side of presenting symptoms, with a gradient of reduced uptake from the putamen to the caudate head.…”

mentioning

confidence: 99%

Relationship between [¹²³I]-FP-CIT SPECT and clinical progression in Parkinson's disease

et al. 2016

View full text Add to dashboard Cite

show abstract

Implementation of the European multicentre database of healthy controls for [123I]FP-CIT SPECT increases diagnostic accuracy in patients with clinically uncertain parkinsonian syndromes

Cited by 29 publications

References 22 publications

The impact of reconstruction and scanner characterisation on the diagnostic capability of a normal database for [123I]FP-CIT SPECT imaging

The impact of reconstruction and scanner characterisation on the diagnostic capability of a normal database for [123I]FP-CIT SPECT imaging

Japanese multicenter database of healthy controls for [123I]FP-CIT SPECT

Relationship between [¹²³I]-FP-CIT SPECT and clinical progression in Parkinson's disease

Contact Info

Product

Resources

About

Implementation of the European multicentre database of healthy controls for [123I]FP-CIT SPECT increases diagnostic accuracy in patients with clinically uncertain parkinsonian syndromes

Cited by 29 publications

References 22 publications

The impact of reconstruction and scanner characterisation on the diagnostic capability of a normal database for [123I]FP-CIT SPECT imaging

The impact of reconstruction and scanner characterisation on the diagnostic capability of a normal database for [123I]FP-CIT SPECT imaging

Japanese multicenter database of healthy controls for [123I]FP-CIT SPECT

Relationship between [123I]-FP-CIT SPECT and clinical progression in Parkinson's disease

Contact Info

Product

Resources

About

Relationship between [¹²³I]-FP-CIT SPECT and clinical progression in Parkinson's disease