Japanese multicenter database of healthy controls for [123I]FP-CIT SPECT

Abstract

PurposeThe aim of this multicenter trial was to generate a [123I]FP-CIT SPECT database of healthy controls from the common SPECT systems available in Japan.MethodsThis study included 510 sets of SPECT data from 256 healthy controls (116 men and 140 women; age range, 30–83 years) acquired from eight different centers. Images were reconstructed without attenuation or scatter correction (NOACNOSC), with only attenuation correction using the Chang method (ChangACNOSC) or X-ray CT (CTACNOSC), and with both scatter and attenuation correction using the Chang method (ChangACSC) or X-ray CT (CTACSC). These SPECT images were analyzed using the Southampton method. The outcome measure was the specific binding ratio (SBR) in the striatum. These striatal SBRs were calibrated from prior experiments using a striatal phantom.ResultsThe original SBRs gradually decreased in the order of ChangACSC, CTACSC, ChangACNOSC, CTACNOSC, and NOACNOSC. The SBRs for NOACNOSC were 46% lower than those for ChangACSC. In contrast, the calibrated SBRs were almost equal under no scatter correction (NOSC) conditions. A significant effect of age was found, with an SBR decline rate of 6.3% per decade. In the 30–39 age group, SBRs were 12.2% higher in women than in men, but this increase declined with age and was absent in the 70–79 age group.ConclusionsThis study provided a large-scale quantitative database of [123I]FP-CIT SPECT scans from different scanners in healthy controls across a wide age range and with balanced sex representation. The phantom calibration effectively harmonizes SPECT data from different SPECT systems under NOSC conditions. The data collected in this study may serve as a reference database. Electronic supplementary materialThe online version of this article (10.1007/s00259-018-3976-5) contains supplementary material, which is available to authorized users.

Single-site 123I-FP-CIT reference values from individuals with non-degenerative parkinsonism—comparison with values from healthy volunteers

“…We obtained an overall rate of SBR decline per decade, averaged over all striatal VOIs and over both genders, of 4.80% (Flash3D) and 5.02% (FBP). This agrees with what has been reported in the literature for healthy volunteers (between 3.6 and 7.5% per decade) (Nicastro et al 2016;Varrone et al 2013;Matsuda et al 2018;Fig. 8 Examples of three test cases used to validate the generated databases: two positive (first and second rows) and one negative (third row) case.…”

“…We also found that regardless of gender and irrespective of the reconstruction method, the rate of SBR decline was faster for putamen compared to that for caudate, and even more so in the posterior region of the putamen compared to that in the anterior region. There are conflicting results on this topic in the literature (Varrone et al 2013;Matsuda et al 2018;Eusebio et al 2012;Kaasinen et al 2015;Volkow et al 2007;Nobili et al 2013) which we believe deserves further investigations.…”

“…However, conflicting reports have been published regarding interhemispheric differences in SBR values. For example, in (Matsuda et al 2018), the authors have reported greater SBRs on the right side, while others have reported greater SBRs on the left side (e.g., (Varrone et al 2013)). Others, like us, found no interhemispheric differences in any of the measured SBRs (Kaasinen et al 2015;Lavalaye et al 2000).…”

“…Our cohort was rigorously selected, in two separate stages, from a pool of patients' data collected over 8 years at the same center and acquired on the same SPECT-CT imaging system following the same acquisition and processing protocols. This helped overcome the inter-center variability and the challenge of recruiting a large enough cohort of healthy volunteers as in the previously published European (n = 139) (Varrone et al 2013) and Japanese (n = 256) (Matsuda et al 2018) databases. To the best of our knowledge, this is the largest cohort of patients with normal 123 I-FP-CIT SPECT, and a well-balanced gender distribution (50.65% men and 49.35% women) across a wide age range (16-88 years).…”

Levodopa-Responsive Primary Slow Orthostatic Tremor: A Premotor Sign of Parkinson’s Disease?

“…The SBR values were 3.31 in the right striatum and 3.50 in the left striatum ( Fig. 2), which are decreased compared with age-matched normal subjects [4].…”