Relationship between [<sup>123</sup>I]-FP-CIT SPECT and clinical progression in Parkinson's disease

Ramani, Lucille; Malek, Naveed; Patterson, J.; Nissen, Thomas; Newman, EJ

doi:10.1111/ane.12613

Cited by 12 publications

(11 citation statements)

References 30 publications

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“…Differences in the striatum support previous neuropathological models for PD motor subtypes in vivo, where AR have reduced dopaminergic projections to the dorsal putamen and TD have reduced projections in the lateral putamen and caudate nucleus 97 . Contrary to these findings, several SPECT studies found no difference between motor subtypes in the anterior or posterior putamen 110–112 . Interestingly, there seems to be a differential pattern of progression in the FP‐CIT binding in the ipsi‐ and contralateral putamen, since nTD had decreased binding over time, while TD showed no differences 98 .…”

Section: Molecular Imagingsupporting

confidence: 76%

“…While the putamen region is the most examined region in PD SPECT studies, few studies report on other dopaminergic regions. When TD was compared against AR, higher uptake was found in the ipsilateral and contralateral caudate nucleus, 97, 107, 108 and in mean caudate uptake, 111 while two studies found no difference in contralateral or ipsilateral caudate binding ratios 105, 112 . Contrary to the findings of higher ipsilateral FP‐CIT uptake in the caudate nucleus, one study found lower ipsilateral striatum and caudate nucleus uptake in TD compared to AR 110 and another showed PD subtypes with the same severity of disease show no difference in caudate uptake ratios 109 …”

Section: Molecular Imagingmentioning

confidence: 88%

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Neuroimaging Detectable Differences between Parkinson's Disease Motor Subtypes: A Systematic Review

Boonstra

Michielse

Temel

et al. 2020

Movement Disord Clin Pract

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Background The neuroanatomical substrates of Parkinson's disease (PD) with tremor‐dominance (TD) and those with non‐tremor dominance (nTD), postural instability and gait difficulty (PIGD), and akinetic‐rigid (AR) are not fully differentiated. A better understanding of symptom specific pathoanatomical markers of PD subtypes may result in earlier diagnosis and more tailored treatment. Here, we aim to give an overview of the neuroimaging literature that compared PD motor subtypes. Methods A systematic literature review on neuroimaging studies of PD subtypes was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. Search terms submitted to the PubMed database included: “Parkinson's disease”, “MRI” and “motor subtypes” (TD, nTD, PIGD, AR). The results are first discussed from macro to micro level of organization (i.e., (1) structural; (2) functional; and (3) molecular) and then by applied imaging methodology. Findings Several neuroimaging methods including diffusion imaging and positron emission tomography (PET) distinguish specific PD motor subtypes well, although findings are mixed. Furthermore, our review demonstrates that nTD‐PD patients have more severe neuroalterations compared to TD‐PD patients. More specifically, nTD‐PD patients have deficits within striato‐thalamo‐cortical (STC) circuitry and other thalamocortical projections related to cognitive and sensorimotor function, while TD‐PD patients tend to have greater cerebello‐thalamo‐cortical (CTC) circuitry dysfunction. Conclusions Based on the literature, STC and CTC circuitry deficits seem to be the key features of PD and the subtypes. Future research should make greater use of multimodal neuroimaging and techniques that have higher sensitivity in delineating subcortical structures involved in motor diseases.

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Section: Molecular Imagingsupporting

confidence: 76%

Section: Molecular Imagingmentioning

confidence: 88%

Neuroimaging Detectable Differences between Parkinson's Disease Motor Subtypes: A Systematic Review

Boonstra

Michielse

Temel

et al. 2020

Movement Disord Clin Pract

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“…As it becomes increasingly obvious that non-motor symptoms are relevant for quality of life it would be helpful to have an imaging marker for the development of cognitive deficits. For example, Ramani and colleagues were able to show that in akinetic-rigid PD patients, the degree of dopaminergic deficiency on [ 123 I]FP-CIT SPECT correlated inversely with motor severity after three years (Ramani et al, 2016). Our results show the importance of the relative DAT availability in the associative subdivision of the striatum for global cognition.…”

Section: Study Strengths and Limitationssupporting

confidence: 52%

Cognitive performance correlates with the degree of dopaminergic degeneration in the associative part of the striatum in non-demented Parkinson’s patients

et al. 2017

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Parkinson's disease (PD) patients show cognitive deficits that are relevant in terms of prognosis and quality of life. Degeneration of striatal dopaminergic afferents proceeds from dorsal/caudal to anterior/ventral and is discussed to account for some of these symptoms. Treatment with dopamine (DA) has differential effects on cognitive dysfunctions, improving some and worsening others. We hypothesized that cognitive performance during the dopaminergic OFF state correlates with DAT availability in the associative striatum. 16 PD patients underwent motor and cognitive examination ON and OFF DA. Global cognition was measured using the Montréal Cognitive Assessment (MoCA) test and executive functioning using a Stroop test. Nigrostriatal dopaminergic innervation was characterized with [I]FP-CIT SPECT. A connectivity atlas of the striatum was used to assess DAT availability in functionally defined striatal subregions. Correlations between imaging data and behavioral data OFF medication were calculated. Correlations between DAT availability and MoCA performance in the dopaminergic OFF state was strongest in the associative part of the striatum (r = 0.674, p = 0.004). MoCA test performance did not differ between the ON and the OFF state. There was no correlation of DAT availability with Stroop performance in the OFF state but performance was significantly better during the ON state. Not only motor but also cognitive dysfunctions in PD are associated with striatal dopaminergic depletion. Cognitive decline in non-demented PD patients goes along with nigrostriatal degeneration, most pronounced in the associative subdivision of the striatum. In addition, the present findings suggest that executive dysfunctions are ameliorated by DA whereas global cognition is not improved by dopaminergic medication.

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“…It was reported that DAT imaging, a presynaptic neuronal functional imaging, is abnormal in the brain of patients with PD (Ramani, Malek, Patterson, Nissen, & Newman, ). This finding improves diagnostic accuracy in PD patients with clinically uncertain parkinsonian symptoms (Ramani et al, ). It was also reported that the downregulation of DAT is an early response to the decrease of endogenous dopamine (Eshuis et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…DAT has fast kinetics, high selectivity, and compatibility for treatments using levodopa (Saeed et al, 2017). It was reported that DAT imaging, a presynaptic neuronal functional imaging, is abnormal in the brain of patients with PD (Ramani, Malek, Patterson, Nissen, & Newman, 2017). This finding improves diagnostic accuracy in PD patients with clinically uncertain parkinsonian symptoms (Ramani et al, 2017).…”

mentioning

confidence: 99%

Head‐to‐head comparison of ¹⁸F‐FP‐CIT and ¹²³I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study

Lee

Kim

Park

et al. 2018

Synapse

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I-FP-CIT and F-FP-CIT are radiotracers which are widely used to diagnose Parkinson's disease (PD). However, to our knowledge, no studies to date have made head-to-head comparisons between I-FP-CIT and F-FP-CIT. Therefore, in this study, I-FP-CIT SPECT/CT was compared with F-FP-CIT PET/CT in the same cohort of subjects. Patients with PD and essential tremor (ET) underwent I-FP-CIT SPECT/CT and F-FP-CIT PET/CT. Visual and semiquantitative analyses were conducted. The specific binding ratio (SBR) and putamen to caudate ratio (PCR) were compared between subjects who underwent I-FP-CIT SPECT/CT and F-FP-CIT PET/CT. Visual analysis showed that the striatal uptake of both radiotracers was decreased in the PD group, whereas striatal uptake was intact in the ET group. The SBR between I-FP-CIT SPECT/CT and F-FP-CIT PET/CT showed a positive correlation (r = .78, p< .01). However, the mean SBRs on F-FP-CIT PET/CT were higher than those on I-FP-CIT SPECT/CT (2.19 ± .87 and 1.22 ± .49, respectively; p < .01). The PCRs in these two modalities were correlated with each other (r = .71, p < .01). The mean PCRs on F-FP-CIT PET/CT were not significantly higher than those on I-FP-CIT SPECT/CT (1.31 ± .19 and 0.98 ± .06, respectively; p = .06). These preliminary results indicate that the uptake of both I-FP-CIT and F-FP-CIT was decreased in the PD group when compared with the ET controls. Visual analyses using both methods did not affect the diagnostic accuracy in this study. However, semiquantitative analysis indicated a better contrast of F-FP-CIT PET/CT relative to I-FP-CIT SPECT/CT.

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Relationship between [¹²³I]-FP-CIT SPECT and clinical progression in Parkinson's disease

Cited by 12 publications

References 30 publications

Neuroimaging Detectable Differences between Parkinson's Disease Motor Subtypes: A Systematic Review

Neuroimaging Detectable Differences between Parkinson's Disease Motor Subtypes: A Systematic Review

Cognitive performance correlates with the degree of dopaminergic degeneration in the associative part of the striatum in non-demented Parkinson’s patients

Head‐to‐head comparison of ¹⁸F‐FP‐CIT and ¹²³I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study

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Relationship between [123I]-FP-CIT SPECT and clinical progression in Parkinson's disease

Cited by 12 publications

References 30 publications

Neuroimaging Detectable Differences between Parkinson's Disease Motor Subtypes: A Systematic Review

Neuroimaging Detectable Differences between Parkinson's Disease Motor Subtypes: A Systematic Review

Cognitive performance correlates with the degree of dopaminergic degeneration in the associative part of the striatum in non-demented Parkinson’s patients

Head‐to‐head comparison of 18F‐FP‐CIT and 123I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study

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Relationship between [¹²³I]-FP-CIT SPECT and clinical progression in Parkinson's disease

Head‐to‐head comparison of ¹⁸F‐FP‐CIT and ¹²³I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study