Implantate aus Glaskeramik in der Knochenchirurgie (tierexperimentelle Untersuchungen)

Effect of Pulverized Implantation Materials (Plastic and Glass Ceramic) on Growth and Metabolism of Mammalian Cell Cultures

“…Thus, future research has to elucidate, whether there are differences in the binding (to the cell surface), uptake (into the cells) and possibly ly sosomal activation between these different cells in response to the pulver ized implantation materials. Generally, it was obvious that these materials are relatively little toxic (especially to fibroblasts) and this finding is in accordance with the relatively good compatibility which occurs after intraosseal, intramuscular and subcutaneous implantation of these materials in dogs, rabbits, rats and guinea pigs [1,2]. These materials were kept in these tissues for more than 2 years (in rats and rabbits) without signs of inflammatory reactions.…”

“…Also, in case of intraosseal implantation no fi brous membrane could be detected between the implanted material and newly formed bone. The implant was surrounded by mature, lamellar, fully mineralized osseous tissue [1]. In case of implantation into soft tis sues, the materials were surrounded by regular, dense collagenous connective tissue with fibroblasts, while macrophages were not present [2].…”

Biomaterials

“…Practically, it is difficult to get the requisite mechanical and surface chemical properties in the same material. Certain compositional ranges of soda-calcia-phospho-silicate glasses (27), the glass-ceramics (Bioglass, Bioglass-Ceramic, Ceravital) (28) and dense biologically reactive hydroxylapatite (Durapatite) (29) develop a chemical bond with living bone. The mechanical limitations of these compositions have required the development of a number of means of using the controlled surface-active materials as a component in a composite system, such as coatings on dense high-strength alumina (30) or surgical alloys (31), as an active filler in bone cement (32), or with metal fiber reinforcement (33).…”

Untersuchungen über die Verwendbarkeit von Glaskeramiken zur Osteo-Odonto-Keratoplastik

“…Sie wurden daher meist in ein knöchernes Implantatlager eingesetzt. Erfahrungen liegen allerdings auch mit Im plantationen in Weichgeweben vor [Blencke et al, 1973[Blencke et al, , 1974[Blencke et al, , 1975 [Hench et al, 1971[Hench et al, -1974[Hench et al, , 1971aBlencke et al, 1973Blencke et al, , 1974Blencke et al, . 1975 …”