Compound bone cement on a PMMA base with an additive of bioactive glass ceramic particles in different portions and different particle sizes are tested in animal experiments. The tissue reactions to extracorporal polymerized specimens and to in situ polymerized specimens are observed. The experiments with an implantation period up to six months demonstrate a tight bonding between the newly formed osseous tissue and the glass ceramic particles at the interface. The inflammatory reactions in the vicinity of the implant are small. It is the objective of the investigations to improve the adherance of the bone cement at the interface to achieve a more durable anchorage of bone cement in the tissue.
The biocompatible and bioactive glass-ceramic material Ceravital, which has been developed, can be adapted to the physiological conditions of the organs by apropriately monitoring its chemical composition. The material exhibits a remarkable long-term stability in in vitro solubility tests and when used as implants in animal experiments.
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