Implantable polymer/metal thin film structures for the localized treatment of cancer by Joule heating

Kan-Dapaah, Kwabena; Rahbar, Nima; Theriault, Christian; Soboyejo, W. O.

doi:10.1063/1.4918271

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…The predictions from the 3D finite element method (FEM) model revealed that, a device with dimensions (polymer shell: 1 × 1 × 0.2 cm, thin layer (nichrome): 0.8 × 0.8 × 12.7 × 10 6 cm and coil spacing: 0.04 cm), achieved hypethermic levels in about 57 s. Furthermore, it was evident from the results that size and shape of lesions could be controlled by factors such as device geometry, applied voltage and treatment time. [ 18 ] These results suggested that our device has the potential to kill post surgery residual cells within reasonable distances from the device surface.…”

Section: Polymer-metal Compositesmentioning

confidence: 86%

Polymeric composite devices for localized treatment of early-stage breast cancer

2017

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For early-stage breast cancers mastectomy is an aggressive form of treatment. Therefore, there is a need for new treatment strategies that can enhance the use of lumpectomy by eliminating residual cancer cells with limited side effects to reduce local recurrence. Although, various radiotherapy-based methods have been developed, residual cells are found in 20–55% of the time at the first operation. Furthermore, some current treatment methods result in poor cosmesis. For the last decade, the authors have been exploring the use of polymeric composite materials in single and multi-modal implantable biomedical devices for post-operative treatment of breast cancer. In this paper, the concept and working principles of the devices, as well as selected results from experimental and numerical investigations, are presented. The results show the potential of the biomedical implants for cancer treatment.

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Section: Polymer-metal Compositesmentioning

confidence: 86%

Polymeric composite devices for localized treatment of early-stage breast cancer

2017

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“…Electro-thermal methods using conventional thermal heaters, evades the problems associated with nanoparticles but suffers from various disadvantages like heavy weight, rigidity, lower heating efficiency and toxicity. Implantable heaters for locally treating cancers were not able to completely overcome all these disadvantages [20,21]. Several of these issues had more or less successfully addressed by using carbon based materials [22][23][24][25], but there are no reported studies on utilizing the Joule heating property of graphene based materials towards cancer thermal therapy.…”

Section: Introductionmentioning

confidence: 99%

Flexible and free-standing reduced graphene oxide thick films with PMMA stabilized silver nanoparticles, as a potential probe for cancer thermal therapy

Asha¹,

Ananth²,

Rajan³

2018

Biomed. Phys. Eng. Express

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Thermal therapy is an efficient, cost-effective method for treating different types of cancers and hence flexible, light weight, biocompatible heating materials with low power consumption are of utmost importance. Partially reduced flexible, robust and bio-compatible thick graphene oxide films with, mostly edge functionalized Polymethyl methacrylate (PMMA) and in situ grown silver nanoparticles were prepared using simple soak and dry strategy. Larger distribution of silver nanoparticles with a mean diameter of 2.5 nm were anchored towards the edges of these thick films. The electrothermal (Joule heating) performance were found to increase in the presence of silver nanoparticles due to decrease in sheet resistance (0.33×10 4 Ωm) and increase in electron-phonon interaction. These freestanding, flexible films exhibited stable Joule heating behavior under repeated voltage on/off cycles.In-vitro studies performed on breast cancer cells in the presence of the prepared films, with an external applied voltage of 10 V DC , shows 67% cell death. This work proves the potentiality of thick heterogeneous (partially) reduced graphene oxide films towards site specific destruction of solid tumors by utilizing its Joule heating properties.

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Laser‐induced heating of polydimethylsiloxane‐magnetite nanocomposites for hyperthermic inhibition of triple‐negative breast cancer cell proliferation

et al. 2022

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This paper presents the results of an experimental and computational study of the effects of laser‐induced heating provided by magnetite nanocomposite structures that are being developed for the localized hyperthermic treatment of triple‐negative breast cancer. Magnetite nanoparticle‐reinforced polydimethylsiloxane (PDMS) nanocomposites were fabricated with weight percentages of 1%, 5%, and 10% magnetite nanoparticles. The nanocomposites were exposed to incident Near Infrared (NIR) laser beams with well‐controlled powers. The laser‐induced heating is explored in: (i) heating liquid media (deionized water and cell growth media [Leibovitz L15+]) to characterize the photothermal properties of the nanocomposites, (ii) in vitro experiments that explore the effects of localized heating on triple‐negative breast cancer cells, and (iii) experiments in which the laser beams penetrate through chicken tissue to heat up nanocomposite samples embedded at different depths beneath the chicken skin. The resulting plasmonic laser‐induced heating is explained using composite theories and heat transport models. The results show that the laser/nanocomposite interactions decrease the viability of triple‐negative breast cancer cells (MDA‐MB‐231) at temperatures in the hyperthermia domain between 41 and 44°C. Laser irradiation did not cause any observed physical damage to the chicken tissue. The potential in vivo performance of the PDMS nanocomposites was also investigated using computational finite element models of the effects of laser/magnetite nanocomposite interactions on the temperatures and thermal doses experienced by tissues that surround the nanocomposite devices. The implications of the results are then discussed for the development of implantable nanocomposite devices for localized treatment of triple‐negative breast cancer tissue via hyperthermia.

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Implantable polymer/metal thin film structures for the localized treatment of cancer by Joule heating

Cited by 3 publications

References 32 publications

Polymeric composite devices for localized treatment of early-stage breast cancer

Polymeric composite devices for localized treatment of early-stage breast cancer

Flexible and free-standing reduced graphene oxide thick films with PMMA stabilized silver nanoparticles, as a potential probe for cancer thermal therapy

Laser‐induced heating of polydimethylsiloxane‐magnetite nanocomposites for hyperthermic inhibition of triple‐negative breast cancer cell proliferation

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