Impairment of Lung Function Increases the Risk of Postoperative Respiratory Failure for Esophageal Carcinoma: A Systematic Review and Meta-Analysis

Sun, Yanming; Zhu, Ying

doi:10.1155/2021/5327682

Cited by 4 publications

(5 citation statements)

References 13 publications

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“…Patients who were older than 65 years, had DM, lower FVC%, higher intraoperative urine volume, and higher APACHE II score had an increased risk of respiratory failure (Figure 2). Pulmonary complications, particularly respiratory failure, have a significant negative impact on the survival of patients undergoing esophageal surgery for EC [9,12,13,19,25,26]. According to the survey, the incidence rate of respiratory failure is as high as 30% [27].…”

Section: Resultsmentioning

confidence: 99%

Risk factors associated with postoperative respiratory failure after esophagectomy for esophageal cancer

Fang,

Yang,

Long

et al. 2023

Exploration of Medicine

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Aim: Respiratory failure is common after esophagectomy for esophageal cancer (EC). This study aimed to identify the risk factors associated with postoperative respiratory failure following esophagectomy for EC. Methods: A single-center observational study from China was conducted on 262 patients with EC who underwent thoracoscopic esophagectomy between April 2014 and June 2016. The patients were divided into two groups: group I (respiratory failure) and group II (without respiratory failure). Demographic and perioperative variables, tumor-related factors, surgical factors, Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, and clinical course were compared between the groups. Univariable and multivariable logistic regression analyses were performed to assess the risk factors of postoperative respiratory failure after esophagectomy. Results: Among the 262 patients, 24 (9.2%) developed respiratory failure. Univariable analysis revealed several risk factors, including age, smoking, comorbidities, partial pressure of oxygen (PO2), partial pressure of carbon dioxide (PCO2), forced vital capacity (FVC), FVC percentage (FVC%), urine volume during surgery, and APACHE II score. Multivariable analysis showed that age, comorbidities of diabetes mellitus (DM), FVC%, urine volume during surgery, and APACHE II score were independent predictors of respiratory failure. Specifically, elderly patients (> 65 years) with comorbidities of DM, lower FVC%, higher urine volume during surgery, and elevated APACHE II score were found to be more susceptible to respiratory failure, resulting in prolonged hospitalization and increased healthcare burden. These findings emphasize the importance of considering these factors in the management and care of patients at risk of respiratory failure. Conclusions: As a common complication following esophagectomy for EC. Respiratory failure is significantly associated with age, comorbidities of DM, FVC%, urine volume during surgery, and APACHE II score in the dataset. The findings will contribute to the evaluation of the risk of respiratory failure and guide early intervention strategies in clinical decision-making.

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Section: Resultsmentioning

confidence: 99%

Risk factors associated with postoperative respiratory failure after esophagectomy for esophageal cancer

Fang,

Yang,

Long

et al. 2023

Exploration of Medicine

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“…Sun et al have explained in their study that cardiothoracic surgeries have major contributions of causing airway obstruction, superficial ventilation due to chest pain, abdominal breathing pattern, hyper-secretion, muscle dysfunctions, and chest and lung restriction. 21…”

Section: Discussionmentioning

confidence: 99%

Frequency of the clinical indicators of ‘ineffective airway clearance’ among patients after coronary artery bypass grafting at tertiary care hospitals Karachi, Pakistan.

Razzaq

Rasheed

Ahmed³

et al. 2023

TPMJ

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Objective: To determine the frequency of the clinical indicators of ineffective airway clearance among patients after Coronary Artery Bypass Grafting at tertiary care hospitals in Karachi, Pakistan. Study Design: Cross-sectional study. Setting: Dow University Hospital (DUH), Ojha Campus, and Tabba Heart Institute (THI) Karachi. Period: December 2019 to July 2020. Material & Methods: A total of 113 patients were enrolled after CABG surgery through purposive sampling nine clinical indicators were assessed in post-CABG patients for the presence of Ineffective Airway Clearance (IAC). A data collection tool with demographic variables and nine clinical indicators (defining characteristics) of IAC was used. The association of clinical indicators with IAC was determined through the Fisher Exact Test. Results: The mean age of study patients was 57.50± 9.107 years. IAC was found in 105 (92.9%) patients in post-CABG surgery patients within 24 hours of intubating of the ventilator. The most frequent clinical indicator was adventitious breath sounds (ABS) which has shown up in 90 (79.6%) patients of the study population. The majority of the indicators were found to be statistically significantly associated with IAC. Conclusion: This study concludes high incidence of IAC 92.2% among the study population of post CABG patients. The most frequent clinical indicator were ABS, excessive sputum, and ineffective cough.

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“…In oncology population, exercise has been shown to reduce cancer recurrence by 48% and cancer mortality by 27%,1 with physical fitness and cardiorespiratory fitness as strong predictors of cancer mortality in cancer survivors 2 3. However, during and after cancer therapy, cancer survivors show an impairment in physical fitness4 and usually present with respiratory dysfunction and have episodes of dyspnoea, especially those diagnosed with thoracic tumours 5 6. It has been proposed that the main cause of these alterations is the weakness of the respiratory muscles, rather than the effects of medical treatments 7 8.…”

Section: Introductionmentioning

confidence: 99%

Cancer survivor inspiratory muscle training: systematic review and Bayesian meta-analysis

Tórtola-Navarro

Gallardo-Gómez

Álvarez-Barbosa

et al. 2022

BMJ Support Palliat Care

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BackgroundThe long-term impact of cancer treatment is associated with respiratory dysfunction and physical fitness impairment. Although inspiratory muscle training (IMT) has been shown as an effective exercise therapy in cancer survivors, there is no evidence on the optimal dose, application moment nor specific population effects of this intervention. The main objective of this meta-analysis is to analyse the effects of IMT on pulmonary function, physical fitness and quality of life (QoL) in cancer survivors.MethodsThis systematic review and meta-analysis was preregistered in the International Prospective Register of Systematic Reviews (PROSPERO) register and conducted according to the Preferred Reporting for Systematic Reviews and Meta-analysis statement. We used a Bayesian multilevel random-effects meta-analysis model to pool the data. Multilevel metaregression models were used to examine the conditional effects of our covariates. Convergence and model fit were evaluated through specific model parameters. Sensitivity analyses removing influential cases and using a frequentist approach were carried out.ResultsPooled data showed that IMT intervention is effective to improve pulmonary function (standardised mean difference=0.53, 95% credible interval 0.13 to 0.94, SE=0.19). However, IMT did not present statistically significant results on physical fitness and QoL. Metaregression analyses found that the type of cancer, the moment of application and the evaluation tool used had significant moderation effects on pulmonary function.ConclusionIMT could be an important part in the management of side effects suffered by cancer survivors. Considering the current evidence, this intervention is highly recommended in patients diagnosed with oesophageal and lung cancers. IMT may provide superior benefits before the biological treatment and after the surgery.PROSPERO registration number304909.

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Impairment of Lung Function Increases the Risk of Postoperative Respiratory Failure for Esophageal Carcinoma: A Systematic Review and Meta-Analysis

Cited by 4 publications

References 13 publications

Risk factors associated with postoperative respiratory failure after esophagectomy for esophageal cancer

Risk factors associated with postoperative respiratory failure after esophagectomy for esophageal cancer

Frequency of the clinical indicators of ‘ineffective airway clearance’ among patients after coronary artery bypass grafting at tertiary care hospitals Karachi, Pakistan.

Cancer survivor inspiratory muscle training: systematic review and Bayesian meta-analysis

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