Impairment of episodic and semantic autobiographical memory in patients with mild cognitive impairment and early Alzheimer's disease

Leyhe, Thomas; Müller, Stephan; Milian, Monika; Eschweiler, Gerhard W.; Saur, Ralf

doi:10.1016/j.neuropsychologia.2009.04.018

Cited by 169 publications

(169 citation statements)

References 40 publications

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“…Moreover, aMCI patients as healthy controls were able to report proportionally more episodic details for recent than remote memories. This diverges from Leyhe et al"s (2009) findings of a decline in the recall of episodic autobiographical memories only for the most recent period in aMCI. This discrepancy may be due to the use of different procedures.…”

Section: Neuropsychological Predictors Of the Proportion Of Internal contrasting

confidence: 99%

“…Bastin et al 19 Discussion This study explored episodic ABM in aMCI patients, a population characterized by impaired episodic memory. Following up on studies that reported a deficit affecting the retrieval of event-specific details in aMCI (Irish et al, 2010;Leyhe et al, 2009;Murphy et al, 2008), our results further provide insight into the cerebral bases of this deficit by looking at the cerebral metabolic correlates of specifically episodic ABMs in a relatively large sample of aMCI patients.…”

Section: Neuropsychological Predictors Of the Proportion Of Internal mentioning

confidence: 52%

“…Recently, episodic ABMs have also been shown to decline in aMCI (Irish et al, 2010;Leyhe et al, 2009;Murphy et al, 2008). In particular, in Murphy et al"s study, patients were given the Autobiographical Interview (Levine et al, 2002) in which they were asked to report episodes Bastin et al 5 they had personally experienced at a specific time and space in four remote periods (early childhood, teenage years, early adulthood, middle adulthood) and a recent period (past year).…”

Section: Introductionmentioning

confidence: 99%

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Episodic autobiographical memory in amnestic mild cognitive impairment: What are the neural correlates?

Bastin¹,

Feyers²,

Jedidi³

et al. 2012

Human Brain Mapping

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Autobiographical memory in amnestic Mild Cognitive Impairment (aMCI) is characterized by impaired retrieval of episodic memories, but relatively preserved personal semantic knowledge.This study aimed to identify (via FDG-PET) the neural substrates of impaired episodic specificity of autobiographical memories in 35 aMCI patients compared with 24 healthy elderly controls.Significant correlations between regional cerebral activity and the proportion of episodic details in autobiographical memories from two life periods were found in specific regions of an autobiographical brain network. In aMCI patients, more than in controls, specifically episodic memories from early adulthood were associated with metabolic activity in the cuneus and in parietal regions. We hypothesized that variable retrieval of episodic autobiographical memories in our aMCI patients would be related to their variable capacity to reactivate specific sensoryperceptual and contextual details of early adulthood events linked to reduced (occipito-parietal) visual imagery and less efficient (parietal) attentional processes. For recent memories (last year), a correlation emerged between the proportion of episodic details and activity in lateral temporal regions and the temporo-parietal junction. Accordingly, variable episodic memory for recent events may be related to the efficiency of controlled search through general events likely to provide cues for the retrieval of episodic details and to the ability to establish a self perspective favouring recollection.

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Section: Neuropsychological Predictors Of the Proportion Of Internal contrasting

confidence: 99%

Section: Neuropsychological Predictors Of the Proportion Of Internal mentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Episodic autobiographical memory in amnestic mild cognitive impairment: What are the neural correlates?

Bastin¹,

Feyers²,

Jedidi³

et al. 2012

Human Brain Mapping

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show abstract

“…family, park), which allowed us to carry out comparable examinations for both temporal directions. Additionally, based on previous studies [5,21,29], we modified the number of events to be retrieved from one (in the standard version) to three past events per life period explored [i.e. four or five life periods, depending on the subject's age; 0-11 years, 12-20 years, 21 to (current age -1) or 21-35 years, 36 to (current age -1) and the previous year].…”

Section: Assessment Of Mental Simulation Of Past and Future Eventsmentioning

confidence: 99%

“…four or five life periods, depending on the subject's age; 0-11 years, 12-20 years, 21 to (current age -1) or 21-35 years, 36 to (current age -1) and the previous year]. The aim of testing a greater number of past recollections was to assess more comprehensively the retrieval process and to avoid the likelihood of the patients providing only the most accessible detailed recollections [5,29]. With regard to the EFT testing, following Addis et al [3], we instructed the participants to generate five events, which could plausibly occur during the coming weeks or months or any interval during the next year.…”

Section: Assessment Of Mental Simulation Of Past and Future Eventsmentioning

confidence: 99%

Impaired mental simulation of specific past and future personal events in non-depressed multiple sclerosis patients

Ernst

Blanc

Seze

et al. 2014

Journal of the Neurological Sciences

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The aims of the present study were (i) to explore autobiographical memory and episodic future thought in multiple sclerosis (MS), using Levine's Autobiographical Interview; (ii) to investigate the influence of the Interview's high retrieval support condition (the specific probe phase) on MS patients' past and future simulations and (iii) to obtain the patients' estimations of their own difficulties, during the test, and in everyday life. To that end, we examined 39 non-depressed relapsing-remitting MS patients and 34 healthy subjects matched for gender, age and education level. The 73 participants underwent an adapted version of the Autobiographical Interview in two conditions: remembering and imagining personal events. The group of patients also underwent an extended neuropsychological baseline, including particularly, anterograde memory and executive functions. The results showed that the MS patients' scores on the baseline were mildly or not impaired. On the contrary, the Autobiographical Interview measure, i.e., the mean number of internal details, for each of the two phases of the test -free recall and specific probe -was significantly lower in simulated past and future events in comparison with the healthy controls. Within each group, autobiographical memory performance was superior to episodic future thought performance. A strong positive correlation was observed between past and future mental simulation scores in both groups.In conclusion, our results showed, for the first time, the co-occurrence of deficit of remembering the past and imagining the future in MS patients. They also showed more difficulty in imagining future events than remembering past events for both patients and normal controls. MS being a neurological condition very frequent in the young adult population, the clinical considerations of our study might be of interest. Indeed, they give rise to new insights on MS patients' daily life difficulties related to impaired mental simulation of personal events despite general abilities, including anterograde memory, only mildly or not impaired.

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Episodic Memory in Neurodegenerative Disorders

Irish¹,

Hornberger²

2015

The Wiley Handbook on the Cognitive Neuroscience of Memory

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Impairment of episodic and semantic autobiographical memory in patients with mild cognitive impairment and early Alzheimer's disease

Cited by 169 publications

References 40 publications

Episodic autobiographical memory in amnestic mild cognitive impairment: What are the neural correlates?

Episodic autobiographical memory in amnestic mild cognitive impairment: What are the neural correlates?

Impaired mental simulation of specific past and future personal events in non-depressed multiple sclerosis patients

Episodic Memory in Neurodegenerative Disorders

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