Episodic autobiographical memory in amnestic mild cognitive impairment: What are the neural correlates?

Bastin, Christine; Feyers, Dorothée; Jedidi, Haroun; Bahri, Mohamed Ali; Degueldre, Christian; Lemaire, Christian; Collette, Fabienne; Salmon, Eric

doi:10.1002/hbm.22032

Cited by 30 publications

(32 citation statements)

References 66 publications

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“…However, the recent period in Eustache et al (2004) study covered the last 5 years and is therefore very different from the recent past explored here (yesterday and today), making the comparison between the two studies tricky. Another study using also the TEMPau task failed to reveal significant correlations between hippocampal metabolism and autobiographical memories experienced during the last 12 months, suggesting that the decline in autobiographical memory in early stages of AD may be due to a dysfunction of other brain regions within the autobiographical core brain network (Bastin et al, 2012), such as the posterior cingulate cortex, already associated to the decline of episodic memory performance (Chételat et al, 2003; Bastin et al, 2010), and the precuneus, involved in visual imagery (Fletcher et al, 1995). In our study, correlations were observed in some of these areas, notably the precuneus but also in the temporo-parieto-occipital junction.…”

Section: Discussionmentioning

confidence: 99%

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Retrieval of Recent Autobiographical Memories is Associated with Slow-Wave Sleep in Early AD

Rauchs¹,

Piolino²,

Bertran³

et al. 2013

Front. Behav. Neurosci.

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Autobiographical memory is commonly impaired in Alzheimer’s disease (AD). However, little is known about the very recent past which is though highly important in daily life adaptation. In addition, the impact of sleep disturbances, also frequently reported in AD, on the consolidation, and retrieval of autobiographical memories remains to be assessed. Using an adaptation of the TEMPau task, we investigated the neural substrates of autobiographical memory for recent events and the potential relationship with sleep in 14 patients with mild AD. On day 1, autobiographical memory was explored across three periods: remote (18–30 years), the last 2 years and the last month. After testing, sleep was recorded using polysomnography. The next day, AD patients benefited a resting-state 18FDG-PET scan and a second exploration of autobiographical memory, focusing on the very recent past (today and yesterday). Total recall and episodic recall scores were obtained. In addition, for all events recalled, Remember responses justified by specific factual, spatial, and temporal details were measured using the Remember/Know paradigm. Retrieval of autobiographical memories was impaired in AD, but recall of young adulthood and very recent events was relatively better compared to the two intermediate periods. Recall of recent events (experienced the day and the day preceding the assessment) was correlated with brain glucose consumption in the precuneus and retrosplenial cortex, the calcarine region, the angular gyrus, and lateral temporal areas. AD patients also provided more Justified Remember responses for events experienced the previous-day than for those experienced the day of the assessment. Moreover, Justified Remember responses obtained for events experienced before sleep were positively correlated with the amount of slow-wave sleep. These data provide the first evidence of an association between the ability to retrieve recent autobiographical memories and sleep in mild AD patients.

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Section: Discussionmentioning

confidence: 99%

“…To sum up, episodic autobiographical memory is impaired in AD, even in the early stages of the disease (Murphy et al, 2008; Leyhe et al, 2009; Irish et al, 2010, 2011; Bastin et al, 2012). This deficit is mainly subserved by the dysfunction or degeneration of medial temporal areas.…”

Section: Introductionmentioning

confidence: 99%

Retrieval of Recent Autobiographical Memories is Associated with Slow-Wave Sleep in Early AD

Rauchs¹,

Piolino²,

Bertran³

et al. 2013

Front. Behav. Neurosci.

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“…Older adults remember the general gist of a memory and associated facts (i.e., recalling a schematic mental representation), but they do not construct events in specific detail (i.e., mental construction) to the same degree as younger adults, a finding replicated numerous times . A selective deficit of internal detail generation has been documented in a host of other conditions marked by MTL atrophy or excisions, including mild cognitive impairment (MCI), which specifically affects episodic memory owing to alterations of the MTL, , and temporal lobe epilepsy (TLE) involving excised or atrophied hippocampi . There is selective hippocampal involvement in constructing and integrating internal details; patients with focal hippocampal damage produce fewer internal, but not external, details when constructing events (for an exception, see Ref.…”

Section: Section One: Mental Constructionmentioning

confidence: 99%

The role of the hippocampus in memory and mental construction

Sheldon

Levine

2016

Ann. N.Y. Acad. Sci.

124

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Much has been learned about the processes that support the remembrance of past autobiographical episodes and their importance for a number of cognitive tasks. This work has focused on hippocampal contributions to constructing coherent mental representations of scenarios for these tasks, which has opened up new questions about the underlying hippocampal mechanisms. We propose a new framework to answer these questions, which incorporates task demands that prompt hippocampal contributions to mental construction, the online formation of such mental representations, and how these demands relate to the functional organization of the hippocampus. Synthesizing findings from autobiographical memory research, our framework suggests that the interaction of two task characteristics influences the recruitment of the hippocampus: (1) the degree of task open-endedness (quantified by the presence/absence of a retrieval framework) and (2) the degree to which the integration of perceptual details is required. These characteristics inform the relative weighting of anterior and posterior hippocampal involvement, following an organizational model in which the anterior and posterior hippocampus support constructions on the basis of conceptual and perceptual representations, respectively. The anticipated outcome of our framework is a refined understanding of hippocampal contributions to memory and to the host of related cognitive functions.

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“…We considered interindividual variability in memory ability and in executive and attention function, as these functions are the main domains of age-related cognitive changes (Craik & Salthouse, 2000;Park & Schwartz, 2000). Individual differences in memory were indexed by the participants' z-score in verbal learning performance (word-pair learning in Liège (Bastin et al, 2012), Encoding Storage Retrieval ESR test (Eustache, Desgranges, & Lalevée, 1998) …”

Section: Cognitive Testingmentioning

confidence: 99%

Cognitive reserve impacts on inter-individual variability in resting-state cerebral metabolism in normal aging

et al. 2012

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There is a great deal of heterogeneity in the impact of aging on cognition and cerebral functioning. One potential factor contributing to individual differences among the elders is the cognitive reserve, which designates the partial protection from the deleterious effects of aging that lifetime experience provides. Neuroimaging studies examining task-related activation in elderly people suggested that cognitive reserve takes the form of more efficient use of brain networks and/or greater ability to recruit alternative networks to compensate for age-related cerebral changes. In this multicentre study, we examined the relationships between cognitive reserve, as measured by education and verbal intelligence, and cerebral metabolism at rest (FDG-PET) in a sample of 74 healthy older participants. Higher degree of education and verbal intelligence was associated with less metabolic activity in the right posterior temporoparietal cortex and the left anterior intraparietal sulcus. Functional connectivity analyses of resting-state fMRI images in a subset of 41 participants indicated that these regions belong to the default mode network and the dorsal attention network respectively. Lower metabolism in the temporoparietal cortex was also associated with better memory abilities. The findings provide evidence for an inverse relationship between cognitive reserve and resting-state activity in key regions of two functional networks respectively involved in internal mentation and goaldirected attention.Liège, the 11 th of June 2012Ref. Dear Pr. Lustig, Please find attached the revision of our manuscript entitled "Cognitive reserve impacts on interindividual variability in resting-state cerebral metabolism in normal aging" that we submit for publication in NeuroImage.We thank you for giving us the opportunity to revise our manuscript. We are also grateful to the Reviewers for their useful suggestions that have all been taken into account in this revised version. Changes to the text appear in bold in the manuscript. Highlights-Variability in cerebral metabolism is related to cognitive reserve in older people.-The correlated regions were part of the default mode and dorsal attention networks.-Higher cognitive reserve might refer to optimized resting-state brain functioning. Response to Reviews Dear Pr. Lustig, dear Reviewers, We thank you for giving us the opportunity to revise our manuscript. We are also grateful to the Reviewers for their useful suggestions that have all been taken into account in this revised version. Changes to the text appear in bold in the manuscript. Please find below detailed answers to each comment.Reviewer #11. Reviewer 1 underlines the lack of clarity of the introduction with respect to the meaning of cerebral differences associated with cognitive reserve. We agree that decreased metabolic activity is not necessarily a positive outcome and that increased and decreased fMRI activity in aging may refer to beneficial or detrimental mechanisms depending on how this correlates with performance. ...

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Episodic autobiographical memory in amnestic mild cognitive impairment: What are the neural correlates?

Cited by 30 publications

References 66 publications

Retrieval of Recent Autobiographical Memories is Associated with Slow-Wave Sleep in Early AD

Retrieval of Recent Autobiographical Memories is Associated with Slow-Wave Sleep in Early AD

The role of the hippocampus in memory and mental construction

Cognitive reserve impacts on inter-individual variability in resting-state cerebral metabolism in normal aging

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