Impairment of endothelium‐dependent arterial dilation in Hashimoto's thyroiditis patients with euthyroidism

Abstract

Endothelial dysfunction exists in HT patients with euthyroidism. Autoimmune reactivity and an elevated Lp(a) level might be responsible for the endothelial dysfunction.

Free Triiodothyronine Concentrations are Inversely Associated with Elevated Carotid Intima-Media Thickness in Middle-Aged and Elderly Chinese Population

“…Thyroid autoimmunity may have an impact on the cardiovascular system independent of the thyroid function. It has been found that endothelial function is diminished in euthyroid subjects with positive anti-TPO antibodies, which possibly reflects an effect of a pathological immune response on early atherosclerotic changes 27) . However, our data showed that the link with C-IMT was roughly similar for FT3 with and without TPOAb and TGAb.…”

“…This study was supported by the grants from the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health (1994DP131044), the China National Clinical Research Center for Metabolic Diseases diate cardiovascular outcome variables and systemic hemodynamic factors may also be involved in the relationship between thyroid hormone status and C-IMT. Nevertheless, the exact mechanisms for these associations remain unclear.. Variations in the thyroid hormone status could affect lipoprotein quality and oxidation 25) , vascular remodeling via an effect on local angiotensin signaling 26) , and endothelial function 27) . In experimental models, T3 has important effects on the vascular system, by inducing relaxation of vascular smooth muscle cells through a direct or indirect effect via activation of nitric oxide synthase and inducing adrenomedullin expression in endothelial cells 28) .…”

An Evaluation of the Metabolic Profile in Total Thyroidectomy

“…In several previous studies of hypothyroidic patients, a decrease in carotid intima media thickness and improvement in endothelial functions and the lipid profile have been shown after treatment with L-thyroxin [21][22][23]. In the current study, although euthyroid was achieved with L-thyroxin treatment, the disorder in the lipid profile continued in the postoperative 1-year follow-up period, systolic and diastolic arterial blood pressures increased and waist circumference values continued to increase.…”

Thyroid Status Compensation and Cardiovascular Parameters in Patients With Primary Hypothyreosis

“…Нет, в частности, единства мнений по вопросу о влиянии гипотиреоза на функцио-нальное состояние эндотелия, которое, по данным одних авторов, нарушается [3,4], а по данным других -нет [5,6]. Практически не изучено влияние ПГТ на состояние правых отделов сердца и аорты.…”

“…У 6 пациентов после достижения ком-пенсации ПГТ исчезли признаки НДФЛЖ, что привело к уменьшению доли лиц с диастолической дисфункцией левого желудочка на 21,5 (2,2-40,8)%. Улучшение функ-ционального состояния левого желудочка стало, по всей видимости, причиной уменьшения ОЛП на 7,9 (3,(8)(9)(10)(11)9) мл и снижения СДЛА на 0,9 (0,4-1,4) мм рт.ст., а ДДЛА -на 2,2 (1,4-2,9) мм рт.ст.…”