Impaired lung function is associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in middle-aged and elderly Chinese

Abstract

BackgroundAssociations between lung function and non-alcoholic fatty liver disease (NAFLD) have been reported. However, evidence from large-scale populations about the relationship is scarce. The objective of the study was to evaluate the relationship between lung function and NAFLD in middle-aged and elderly Chinese.MethodsA total of 1842 participants aged 40 years or older were recruited from Chongming District, Shanghai, China. Lung function, evaluated by forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) was measured with standard spirometry. The NAFLD was evaluated by ultrasonography.ResultsThe subjects with NAFLD had lower FVC (% predicted) (0.85 ± 0.26 vs. 0.90 ± 0.28, p < 0.001) and FEV1 (% predicted) (0.93 ± 0.29 vs. 0.98 ± 0.34, p < 0.001) than non-NAFLD. After adjusting for potential risk factors, the lowest quartile of FVC (% predicted) and FEV1 (% predicted) was associated with increased prevalence of NAFLD, with the fully adjusted odds ratio of 1.37 and 1.24 (95% confidence interval [CI] 1.18–1.97, p < 0.001, 95% CI 1.11–1.87, p = 0.009), respectively.ConclusionsImpaired lung function is associated with non-alcoholic fatty liver disease, independent of conventional metabolic risk factors.

Relationship between obstructive lung disease and non-alcoholic fatty liver disease in the Korean population: Korea National Health and Nutrition Examination Survey, 2007&ndash;2010

“…In a study of 111 subjects with COPD, Viglino et al25 showed that NAFLD is highly prevalent in individuals with COPD and might contribute to cardiometabolic comorbidities. Similarly, Mapel and Marton26 and Qin et al27 demonstrated that subjects who have impaired lung function or are diagnosed with COPD are at a higher risk of developing NAFLD. Other studies14,17,28,29 showed that NAFLD and liver disease patients have impaired lung function or a higher prevalence of COPD.…”

Nonalcoholic fatty liver disease and COPD: is it time to cross the diaphragm?

“…Given its association with a wide range of cardiovascular, renal, endocrine and other manifestations, NAFLD is definitely a systemic disorder [18,19]. Not unexpectedly, a few studies have reported on the association of NAFLD and pulmonary function, including COPD (table 1) [1,[20][21][22][23][24][25]. Is this a chance association?…”

The association between the metabolic syndrome and metabolic syndrome score and pulmonary function in non-smoking adults

“…[11][12][13] Recently, research on MetS and pulmonary function has gained momentum worldwide. [14][15][16][17][18] However, to our knowledge, no study involving large-scale populations to assess the relationship between MetS and decreased pulmonary function in non-smoking adults has been conducted. In addition, it is unclear whether the association can be observed in Korean populations.…”