Nonalcoholic fatty liver disease and COPD: is it time to cross the diaphragm?

Lonardo, Amedeo; Nascimbeni, Fabio; Leòn, Maurizio Ponz de

doi:10.1183/13993003.00546-2017

Cited by 19 publications

(17 citation statements)

References 32 publications

(47 reference statements)

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“…Lonardo et al13 believed that there is strong epidemiological and clinical evidence supporting the notion that NAFLD and COPD, which are highly prevalent, non-communicable, lifestyle-related systemic disorders primarily clustered in the metabolic and cardiovascular area with a similar pathogenic background and a high comorbidity rate, are related not by chance but also by pathobiological necessity. However, this relationship has not been evaluated thoroughly.…”

Section: Introductionmentioning

confidence: 99%

Relationship between obstructive lung disease and non-alcoholic fatty liver disease in the Korean population: Korea National Health and Nutrition Examination Survey, 2007–2010

Moon¹,

Kim²,

Jung³

et al. 2018

COPD

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PurposePrevious studies have shown that progressive forms of non-alcoholic fatty liver disease (NAFLD) occur frequently in patients with obstructive lung disease (OLD). However, few studies have written about this relationship. This study aimed to investigate the relationship between OLD and NAFLD.Subjects and methodsThe Korea National Health and Nutrition Examination Survey is a national population-based, cross-sectional surveillance program that was initiated to assess the health and nutritional status of the Korean population. From 2007 to 2010, 11,738 subjects were enrolled. The subjects were defined as having NAFLD when they had scores higher than −0.640 in a NAFLD liver fat score prediction model, which was a previously validated prediction score. Individuals with forced expiratory volume in one second/forced vital capacity <0.7 were considered to have OLD. The subjects were divided into non-OLD and OLD groups and non-NAFLD and NAFLD groups. All analyses were performed using sample weighting using the complex samples plan.ResultsThe prevalences of NAFLD and OLD were 30.2% and 8.9%, respectively. Although not statistically significant, subjects in the NAFLD group involved a higher tendency of having OLD than did those in the non-NAFLD group (8.5% vs 10.0%, respectively, P=0.060). Subjects with OLD showed a higher tendency to have NAFLD than non-OLD subjects (30.0% vs 33.7%, respectively, P=0.060). NAFLD subjects were at higher odds of OLD (odds ratio=1.334; 95% confidence interval=1.108–1.607, P=0.002) than non-NAFLD subjects, after adjusting for age, sex, and smoking history. OLD subjects were at higher odds of NAFLD (odds ratio=1.556; 95% confidence interval=1.288–1.879, P<0.001) than non-OLD subjects, after adjusting for age, sex, and smoking history.ConclusionThis study showed that NAFLD is related to OLD. Clinicians should be aware of possible liver comorbidities in OLD patients and that extrahepatic disease in NAFLD patients may vary more than previously thought.

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Section: Introductionmentioning

confidence: 99%

Relationship between obstructive lung disease and non-alcoholic fatty liver disease in the Korean population: Korea National Health and Nutrition Examination Survey, 2007–2010

Moon¹,

Kim²,

Jung³

et al. 2018

COPD

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“…NAFLD is highly prevalent and is considered as one of the contributors of cardio-metabolic comorbidities in patients with COPD. 20 According to a recent meta- analysis, NAFLD is strongly associated with reduced pulmonary function. Reduced lung volumes at baseline were also associated with increased NAFLD incidence, especially in Asians.…”

Section: Discussionmentioning

confidence: 99%

<p>Hepatic Fibrosis Assessed Using Fibrosis-4 Index Is Predictive of All-Cause Mortality in Patients with Chronic Obstructive Pulmonary Disease</p>

Yong

Leem

Kim

et al. 2020

COPD

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Background: Various comorbidities influence the prognosis of patients with chronic obstructive pulmonary disease (COPD). We investigated if liver fibrosis assessed using fibrosis-4 index (FIB-4) is associated with all-cause mortality in patients with COPD. Methods: We included 756 patients diagnosed with COPD between 2006 and 2010. Medical records were retrospectively reviewed until 2018. FIB-4 was calculated using the following equation: [age (years) × aspartate aminotransferase (IU/L)/(platelet count (10 9 /L) × √alanine aminotransferase (IU/L))]. Results: From a total of 756 patients, 582 (76.9%) patients were categorized into survivor and 174 (23.1%) into non-survivor groups. The non-survivor group was significantly older with a higher proportion of male, smoker and lower FEV 1 /FVC ratio than the survivor group (all P<0.05). Various comorbidities were more frequently observed in the non-survivor group (P<0.05). In addition, the non-survivor group had significantly higher FIB-4 than the survivor group (1.8 vs 1.4, P<0.001). In multivariate analysis, older age (hazard ratio [HR] =1.05), underlying malignancy (HR=2.94), coronary artery occlusive disease (HR=1.58), higher FIB-4 (HR=1.15), and higher GOLD stage (HR=1.26) were significantly associated with the increased risk of all-cause mortality (P<0.05), whereas body mass index (HR=0.95) was independently protective for all-cause mortality (all P<0.05). The high FIB-4 (>1.57) group showed a significantly lower cumulative survival rate than the low FIB-4 (≤1.05) group (P=0.031, Log-rank test). In multivariate regression analysis, higher FIB-4 independently predicted the risk of acute exacerbation (odds ratio=1.08, P=0.034). Conclusion: Higher fibrotic burden assessed using FIB-4 was independently predictive of the increased risk of all-cause mortality and acute exacerbation in patients with COPD.

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“…В декількох до-слідженнях повідомляється про зв'язок НАЖХП із функціональним станом легень, у тому числі про її асоціацію з ХОЗЛ [15][16][17][18][19][20][21].…”

Section: обговоренняunclassified

“…Lonardo et al [15] наголошують на тому, що вірогідність невипадкового зв'язку між НАЖХП та ХОЗЛ підсилюється великим спектром схо-жості печінки та легень як у здорових осіб, так і за наявності патології. Як легені, так і печін-ка є органами з підсиленою васкуляризацією та подвійним кровопостачанням, беруть участь в обробці антигенів і є головними регуляторами енергетичного гомеостазу.…”

Section: обговоренняunclassified

Ендотеліальна Дисфункція Та Морфофункціональні Властивості Еритроцитів При Неалкогольному Стеатогепатиті, Поєднаному З Хронічним Обструктивним Захворюванням Легень, У Хворих На Ожиріння

Cyntar¹,

Федів²,

Stupnytska³

et al. 2021

Mìžnarodnij endokrinologìčnij žurnal

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Nonalcoholic fatty liver disease and COPD: is it time to cross the diaphragm?

Cited by 19 publications

References 32 publications

Relationship between obstructive lung disease and non-alcoholic fatty liver disease in the Korean population: Korea National Health and Nutrition Examination Survey, 2007–2010

Relationship between obstructive lung disease and non-alcoholic fatty liver disease in the Korean population: Korea National Health and Nutrition Examination Survey, 2007–2010

<p>Hepatic Fibrosis Assessed Using Fibrosis-4 Index Is Predictive of All-Cause Mortality in Patients with Chronic Obstructive Pulmonary Disease</p>

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Nonalcoholic fatty liver disease and COPD: is it time to cross the diaphragm?

Cited by 19 publications

References 32 publications

Relationship between obstructive lung disease and non-alcoholic fatty liver disease in the Korean population: Korea National Health and Nutrition Examination Survey, 2007&ndash;2010

Relationship between obstructive lung disease and non-alcoholic fatty liver disease in the Korean population: Korea National Health and Nutrition Examination Survey, 2007&ndash;2010

<p>Hepatic Fibrosis Assessed Using Fibrosis-4 Index Is Predictive of All-Cause Mortality in Patients with Chronic Obstructive Pulmonary Disease</p>

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Relationship between obstructive lung disease and non-alcoholic fatty liver disease in the Korean population: Korea National Health and Nutrition Examination Survey, 2007–2010

Relationship between obstructive lung disease and non-alcoholic fatty liver disease in the Korean population: Korea National Health and Nutrition Examination Survey, 2007–2010