The association between the metabolic syndrome and metabolic syndrome score and pulmonary function in non-smoking adults

Yoon, Hyun Ju; Gi, Mi Young; Ae, Ju; Yoo, Chan Uk; Park, Sang Muk

doi:10.1177/1479164117746022

Cited by 8 publications

(5 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Contrary to previous studies, this study found that MS and OLD were negatively correlated in women, whereas the MS score was negatively correlated with the incidence of OLD [ 16 , 39 , 40 ]. However, after a careful observation of the relationship between MS components and OLD, this study found that HDL-C plays a more vital role than other metabolic components and is notably negatively correlated with FEV1 and FVC in women.…”

Section: Discussioncontrasting

confidence: 99%

High-Density Lipoprotein Cholesterol: A Component of the Metabolic Syndrome with a New Role in Lung Function

Wang

Tian

Zhao

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background. A considerable uncertainty exists about the relationship between adult metabolic syndrome (MS) and obstructive lung disease (OLD), perhaps owing to systemic inflammation. Therefore, this study aimed to investigate the relationship between MS (with its components) and the patterns of lung function impairment. Methods. The participants in this study were 3978 adults aged 30-78 years from the baseline cohort of the Ningxia Cohort Study. The participants underwent pulmonary function tests, questionnaire surveys, physical examinations, and analysis of blood specimens. Results. No significant difference in the prevalence of OLD was observed between male (15.9%) and female (14.2%) participants. After adjusting for possible confounding factors (e.g., age and family income), impaired lung function was found to be related to some MS components, such as abdominal obesity, high blood pressure, and low levels of high-density lipoprotein cholesterol (HDL-C) (all P < 0.05 ). Conclusions. As an important component of MS, abdominal obesity is related to impaired lung function. Surprisingly, this study found that increased HDL-C levels could accelerate the decline of lung function; it also suggests that in the presence of different metabolic health conditions, especially abdominal obesity and low levels of HDL-C, various metabolic indicators should be comprehensively considered to prevent the decline of lung function. This partly explains the increase in the incidence of two or more chronic diseases. Therefore, the prevention of chronic diseases should shift from single-disease prevention to a comprehensive consideration of multi-disease prevention in the future. Therefore, a more sensitive evaluation of the role of HDL-C in lung function is warranted.

show abstract

Section: Discussioncontrasting

confidence: 99%

High-Density Lipoprotein Cholesterol: A Component of the Metabolic Syndrome with a New Role in Lung Function

Wang

Tian

Zhao

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…In this study, MetS was associated with decreased prediction ability of OLD in females, and MetS score was negatively correlated with the incidence of OLD. This contradicts previous research [15,37,38]. However, after careful observation, we found that HDL-C played a crucial role in our study, and it was signi cantly negatively correlated with FVC and FEV1 in females, while other MetS components had relatively little effect on OLD.…”

Section: Discussioncontrasting

confidence: 99%

Association Between Metabolic Syndrome and Lung Function in Rural Areas in China

Wang¹,

Tian²,

Zhao³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background There remains considerable uncertainty about the association between adult metabolic syndrome (MetS) and obstructive lung disease (OLD) possibly through generalized systemic inflammation. The purpose of this study was to investigate the relationship between MetS and its components and lung function patterns. Methods Participants (n = 3978) were drawn from Pingluo and Qingtongxia residents at baseline from the Ningxia Cohort Study. The MetS was assessed according to the criteria of National Cholesterol Education Program III. Spirometric parameters were measured to define lung function. Through multiple linear regression and logistic regression analysis, these relationships were tested. Results The prevalence of obstructive lung disease (OLD) was comparable between genders (15.9% and 14.2%). The prevalence of obstructive pulmonary disease (OLD) was comparable between genders (15.9% and 14.2%), but the prevalence of MetS in males with co-existent OLD was lower than that in females (32.9% and 40.8%). After adjusting for potential confounders such as age and family income group, impaired lung function was associated with individual components of the metabolic syndrome, such as abdominal obesity, hypertension, and low HDL -C(all parameters were p < 0.05). Conclusions As an important component of MetS, abdominal obesity is associated with impaired lung function. Surprisingly, there is a negative correlation between HDL-C and lung function, and the presence of this relationship suggests a new understanding of the role of HDL-C.

show abstract

“…We observed an increased risk of RVD with increasing numbers of metabolic abnormalities, which was consistent with those reported by other researchers [7], [19, 25]. However, the results are not consistent in terms of the correlation between MetS and OVD [26]. Lam et al classified patients of COPD from I to IV according to GOLD criteria, and found only a significant correlation between MetS and the worst COPD groups [27], which came up with similar results in a study on Japanese men [28].…”

Section: Discussionsupporting

confidence: 86%

The gender gap in the relationship between Metabolic Syndrome and Restrictive Ventilatory Defect

Chu,

Yang,

Chen

et al. 2023

Preprint

View full text Add to dashboard Cite

BackgroundGiven the fundamental physiological differences between the sexes, this study aimed to investigate the effect of metabolic syndrome on ventilatory defects stratified by sex.MethodsWe conducted a nationwide, pooled, cross-sectional study. Data of 45,788 participants (men, n=15,859; women, n=29,929) aged 30 years or more were obtained from the Taiwan Biobank. Age-sex adjusted and multivariate logistic regression models were used to estimate the risk of developing impaired pulmonary function (restrictive or obstructive ventilatory defect) in individuals with or without metabolic syndromes. Separate models were also used to estimate for the risk of metabolic syndrome scores and the risk of individual metabolic abnormalities on the risk of restrictive ventilatory defect.ResultsThe overall prevalence of metabolic syndrome was estimated to be 15.9% in Taiwan, much higher in men than in women (18.6% versus 14.4%). Significant association was observed on the effect of metabolic syndromes on the risk of restrictive ventilatory defect. The risk of developing restrictive ventilator defect was 35% higher in participants with metabolic syndromes (odds ratio, 1.35; 95% confidence interval, 1.26-1.45) than those without metabolic syndromes. Elevated blood pressure and triglycerides abnormality were important predictors of restrictive ventilator defect.Sex-stratified subgroup analyses of the individual metabolic abnormalities indicated that men with abdominal obesity and women with dysglycemia were more likely to develop restrictive ventilatory defect.ConclusionOur study evidences suggested that metabolic syndromes were important predictors of impaired pulmonary function and increased risk of developing restrictive ventilatory defects, and its risk increased with increasing numbers of metabolic abnormalities.

show abstract

The association between the metabolic syndrome and metabolic syndrome score and pulmonary function in non-smoking adults

Cited by 8 publications

References 40 publications

High-Density Lipoprotein Cholesterol: A Component of the Metabolic Syndrome with a New Role in Lung Function

High-Density Lipoprotein Cholesterol: A Component of the Metabolic Syndrome with a New Role in Lung Function

Association Between Metabolic Syndrome and Lung Function in Rural Areas in China

The gender gap in the relationship between Metabolic Syndrome and Restrictive Ventilatory Defect

Contact Info

Product

Resources

About