Impaired health-related quality of life in children and adolescents with chronic conditions: a comparative analysis of 10 disease clusters and 33 disease categories/severities utilizing the PedsQL™ 4.0 Generic Core Scales

Varni, James W.; Limbers, Christine A.; Burwinkle, Tasha M.

doi:10.1186/1477-7525-5-43

Cited by 772 publications

(878 citation statements)

References 44 publications

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“…These results emphasise the need for addressing the issue of diagnosis and presence of late effects in QoL studies in childhood cancer survivors. Our results are consistent with other studies of reduced QoL among children surviving brain tumours (Upton et al, 2005;Cardarelli et al, 2006;Varni et al, 2007;Penn et al, 2009;Yoo et al, 2010), as well as among studies and reviews of late effects and QoL of childhood cancer (Pemberger et al, 2005;Calaminus et al, 2007;Eiser et al, 2007;Ishida et al, 2010a, b).…”

Section: Child and Parent Proxy Reportssupporting

confidence: 93%

“…In general, adolescents surviving cancer reported a QoL similar to controls, while parents reported an overall poorer QoL for their children surviving cancer compared to controls. This is consistent with other QoL studies of childhood cancer comparing parent and child ratings with controls (Sawyer et al, 1999;Russell et al, 2006;Varni et al, 2007).…”

Section: Child and Parent Proxy Reportssupporting

confidence: 91%

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Quality of life in children and adolescents surviving cancer

Eilertsen¹,

Jozefiak

Rannestad³

et al. 2012

European Journal of Oncology Nursing

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Section: Child and Parent Proxy Reportssupporting

confidence: 93%

Section: Child and Parent Proxy Reportssupporting

confidence: 91%

Quality of life in children and adolescents surviving cancer

Eilertsen¹,

Jozefiak

Rannestad³

et al. 2012

European Journal of Oncology Nursing

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“…The PedsQL has been shown to be valid and reliable for both self and parent-proxy administration, and is also sensitive to differences between disease types and between severity groups within the same disease. [12][13][14] In this analysis, the physical and psychosocial health summary scores of the PedsQL were used.…”

Section: Hrqol Instrumentsmentioning

confidence: 99%

Longitudinal Changes in Health-Related Quality of Life for Chronic Diseases: An Example in Hemophilia A

2014

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BACKGROUND:Patients with well-managed rare chronic diseases such as hemophilia maintain a stable health state and health-related quality of life (HrQoL) that may be affected by acute events. Longitudinal HrQoL assessments analyzed using multivariate multilevel (MVML) modelling can determine the impact of such events on individuals (within-person effect) and identify factors influencing within-population differences (between-person effect). OBJECTIVES: To demonstrate the application of MVML modelling in a longitudinal study of HrQoL in hemophilia A. METHODS/DESIGN/PARTICIPANTS: Using data on 136 adults and 125 children from a two-year observational cohort study of burden of illness in US hemophilia A patients, MVML modelling determined the effect of time-invariant (sociodemographic and clinical characteristics) and time-varying factors (bleeding frequency, emergency room visits, and missed work/school days) on within-person and between-person HrQoL changes. HrQoL was assessed using the SF-12 health survey (adults) and PedsQL inventory (children) at baseline, then every 6 months. RESULTS: In children, within-person (p<0.0001) and between-person (p<0.0001) psychosocial functioning was reduced by each additional bleed and missed day (within-person: p=0.0089; between-person: p=0.0060). Within-person physical functioning was reduced by each additional bleed (p<0.0001), emergency room (ER) visit (p=0.0284), and missed day (p= 0.0473). Between-persons, additional missed days (p<0.0001) significantly decreased physical functioning. In adults, each additional missed day reduced SF-12 Health Survey mental (p=0.0025) and physical (p=0.0093) component summary scores. Each additional bleed also decreased physical component summary (PCS) significantly (p=0.0093). CONCLUSIONS: This study demonstrated the applicability of MVML modelling in identifying time-invariant and time-varying factors influencing HrQoL in a rare chronic disease population. Small but significant within-person and between-person changes in HrQoL with each additional acute event experienced were identified, which if frequent, could have a large cumulative impact. The results suggest that MVML modelling may be applied to future studies of longitudinal change in HrQoL in other rare chronic disease populations.KEY WORDS: health-related quality of life; hemophilia A; longitudinal; chronic disease; rare disease.

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“…The importance of excess body weight for impaired health-related quality of life (HRQOL) in children and adolescents has been documented in both clinical and population-based studies (15)(16)(17)(18)(19)(20)(21)(22) . However, only a few studies have looked at the importance of the factors underlying excess body weight -being diet quality and PA -for HRQOL.…”

mentioning

confidence: 99%

Diet quality, physical activity, body weight and health-related quality of life among grade 5 students in Canada

Öhinmaa

Veugelers

2011

Public Health Nutr.

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Objective: To assess how diet quality, physical activity and body weight are related to health-related quality of life (HRQOL) among children in the Canadian province of Alberta. Design: In 2008, we surveyed 3421 grade 5 students and their parents from 148 randomly selected schools. Students completed the Harvard Food Frequency Questionnaire, questions on physical activities, and had their height and weight measured. The HRQOL of the students was assessed using the EQ-5D-Y. Parents completed questions on socio-economic background and children's lifestyle. We applied multilevel regression methods to examine the importance of children's diet quality, physical activity and weight status for the EQ-5D-Y Visual Analogue Scale and for the EQ-5D-Y dimensions. Setting: The province of Alberta, Canada. Subjects: Grade 5 students. Results: Students with better diet quality, higher physical activity levels and normal body weights were statistically significantly more likely to report better HRQOL than students who ate less healthily, were less active or were overweight or obese. Conclusions: The importance of diet quality, physical activity and body weight status for HRQOL may help justify broader implementation of school health programmes that promote healthy eating and active living, as these programmes will help reduce the burden of childhood obesity and improve quality of life.

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Impaired health-related quality of life in children and adolescents with chronic conditions: a comparative analysis of 10 disease clusters and 33 disease categories/severities utilizing the PedsQL™ 4.0 Generic Core Scales

Cited by 772 publications

References 44 publications

Quality of life in children and adolescents surviving cancer

Quality of life in children and adolescents surviving cancer

Longitudinal Changes in Health-Related Quality of Life for Chronic Diseases: An Example in Hemophilia A

Diet quality, physical activity, body weight and health-related quality of life among grade 5 students in Canada

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