Impaired endometrial receptivity in primary infertility in women with undifferentiated connective tissue dysplasia and hereditary thrombophilia

Zanozin, A. S.; Демура, Т. А.; Kolosovsky, D Yu; Файзуллина, Н. М.; Kogan, E. A.

doi:10.17116/patol201678623-29

Cited by 4 publications

(6 citation statements)

References 7 publications

(8 reference statements)

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“…A study by Zanozin et al . (2016) reported that fibrosis tissue remodelling is blocked in chronic endometritis (CE), which leads to increased endometrial stromal sclerosis, poor endometrial receptivity, and subsequently infertility.…”

Section: Discussionmentioning

confidence: 99%

Endometritis - Diagnosis,Treatment and its impact on fertility - A Scoping Review

Singh¹,

Sethi²

2022

JBRA

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Endometritis is defined as an infection or inflammation of the endometrium. Endometritis is of two types: acute and chronic. Acute endometritis is the symptomatic acute inflammation of the endometrium, which upon examination with a microscope shows micro-abscess and neutrophil invasion in the superficial endometrium. One of its most common manifestations is postpartum endometritis. Chronic endometritis is a silent disease usually diagnosed on the workup of secondary amenorrhoea and infertility. An important cause of chronic endometritis is tuberculosis, especially in developing nations. Chronic and acute endometritis have been associated with poor reproductive outcomes. Worse outcomes have been reported for individuals with chronic endometritis. This is a scoping review of endometritis and its impact on fertility.

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Section: Discussionmentioning

confidence: 99%

Endometritis - Diagnosis,Treatment and its impact on fertility - A Scoping Review

Singh¹,

Sethi²

2022

JBRA

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“…Zanozin et al (36) have shown that fibrosis tissue remodeling is essentially blocked in fibrosis tissue disease, resulting in increased endometrial stromal sclerosis, decreased endometrial receptivity, and infertility. Currently, avb3 is one of the strongest evidences of endometrial receptivity markers (37).…”

Section: The Influence Of Ce On Endometrial Receptivity and Reproductive Prognosismentioning

confidence: 99%

The impact of chronic endometritis on endometrial fibrosis and reproductive prognosis in patients with moderate and severe intrauterine adhesions: a prospective cohort study

Liu

Yang

Guo

et al. 2019

Fertility and Sterility

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Objective: To study the effect of chronic endometritis (CE) diagnosed by CD138 immunohistochemical (IHC) staining on endometrial fibrosis and reproductive prognosis in patients with moderate or severe intrauterine adhesions (IUAs). Design: Prospective cohort study (Canadian Task Force classification II-2). Setting: University-affiliated hospital. Patient(s): One hundred sixty-seven women with moderate to severe IUAs. Intervention(s): Transcervical resection of adhesions (TCRA) and endometrial biopsy were performed in all patients. According to results of IHC staining with anti-syndecan-1 antibodies to identify CD138 cells, participants were classified into two groups: 78 patients with CE (CE group) and 89 women without CE (NCE group). IHC staining for fibrosis markers transforming growth factor beta 1, antifibrosis markers matrix metalloproteinase 9, and endometrial receptivity marker integrin alpha v beta 3 was later applied to all tissue samples. Main Outcome Measure(s): Endometrial fibrosis, endometrial receptivity, and reproductive prognosis. Result(s): CE diagnosed by CD138 IHC staining has a high incidence, 46%, in moderate and severe IUAs. In the CE group, the expression of transforming growth factor beta 1 was higher than that in the NCE group, and the expression of matrix metalloproteinase 9 and alpha v beta 3 was lower than that in the NCE group. The pregnancy rate and live birth rate in the NCE group were higher than those in the CE group (42.7% vs. 31.5%, 26.9% vs. 17.9%). Conclusion(s): CE may affect the endometrial fibrosis homeostasis in IUAs. Women with CE were more likely to experience recurrence of adhesions and had poorer reproductive outcomes.

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“…Endometrial receptivity is a key factor in embryo implantation. Decreased endometrial receptivity was found in patients with IUAs due to fibrosis tissue 22 . CE had a close relationship with IUAs, in which the formation of fibrosis tissue was one of the main clinical characteristics.…”

Section: Discussionmentioning

confidence: 83%

“…Decreased endometrial receptivity was found in patients with IUAs due to fibrosis tissue. 22 CE had a close relationship with IUAs, in which the formation of fibrosis tissue was one of the main clinical characteristics. Lower expression of ανβ3, a strong-evidence marker of endometrial receptivity, was found in patients with both IUAs and CE.…”

Section: Itemsmentioning

confidence: 99%

Chronic endometritis positively correlates with the aggravation of intrauterine adhesions but has limited effects on reproductive prognosis with antibiotic application

Xiang

et al. 2022

Intl J Gynecology & Obste

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Objective To assess the effect of chronic endometritis (CE) diagnosed by CD138 staining on the aggravation of intrauterine adhesions (IUAs), and the reproductive prognosis after transcervical resection of adhesions (TCRA). Methods Sixty‐three patients with severe IUAs (group A) and 119 patients with moderate IUAs (group B) were included in this retrospective study. TCRA and endometrial biopsy with CD138 staining were performed. Participants in each group were classified into two subgroups: CE group and NCE group (without CE). Patients were treated with a course of oral antibiotics for 2 weeks after TCRA. Embryo transfer would be performed if patients had embryos after operations. Results Increased incidence of CE was found in group A (18/63, 28.57%) compared with group B (18/119, 15.13%) (P = 0.030). No significant differences were found in the comparisons of chemical pregnancy rate, early miscarriage rate, or full‐term pregnancy rate between the CE group and NCE group (P > 0.05), in either the subgroup analysis of group A and group B, or the total analysis. Conclusion CE has a positive correlation with the aggravation of IUAs. CE did not have a negative impact on the reproductive prognosis of patients with moderate or severe IUAs after TCRA followed by antibiotic administration.

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Impaired endometrial receptivity in primary infertility in women with undifferentiated connective tissue dysplasia and hereditary thrombophilia

Cited by 4 publications

References 7 publications

Endometritis - Diagnosis,Treatment and its impact on fertility - A Scoping Review

Endometritis - Diagnosis,Treatment and its impact on fertility - A Scoping Review

The impact of chronic endometritis on endometrial fibrosis and reproductive prognosis in patients with moderate and severe intrauterine adhesions: a prospective cohort study

Chronic endometritis positively correlates with the aggravation of intrauterine adhesions but has limited effects on reproductive prognosis with antibiotic application

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