Impacts of Terrestrial Ionizing Radiation on the Hematopoietic System

Shahid, Saman; Chauhdry, Muhammad Nawaz; Mahmood, Nasir; Sheikh, Shaharyar

doi:10.15244/pjoes/37759

Cited by 8 publications

(11 citation statements)

References 72 publications

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“…A study carried out on a group of terrestrial radiation-exposed individuals revealed decreases in most hematological parameters, including some red blood indices, hemoglobin, hematocrit, neutrophils, and platelets, while increases were observed in red blood cells and lymphocytes. 14 Our findings for neutrophils, lymphocytes, and mean cell hemoglobin concentration were within the same range as the earlier report, 14 therefore confirming that chronic exposure to any source of radiation even at a low level may lead to significant adverse impacts on human health and the development of diseases. Defective lymphoid organs and ineffective hematopoiesis were shown in the literature to depend on the absorbed doses of radiation by tissues.…”

Section: Discussionsupporting

confidence: 89%

Radiologic technologists in Saudi Arabia

Makkawi

Alasmari

Shubayr

et al. 2021

SMJ

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Objectives: To determine the influence of prolonged exposure to radiation based on dosimeter readings on hematological parameters among radiologic technologists (RTs) in Saudi Arabia. Methods:The study was specifically conducted on selected RTs with experience of more than 10 years and the highest thermoluminescent dosimeter (TLD) readings among all RTs in the Radiological Department, Sabya General Hospital, Ministry of Health, Saudi Arabia from August to October 2020. The RTs group was compared with a control group of non-irradiated participants. Blood samples were collected for hematological and coagulation profile evaluation. Results:The acquired radiation dose analysis revealed that the average accumulated dose in 10 years is 7.6 mSv. The medians of prothrombin time (PT) and activated partial thromboplastin time (APTT) of the RTs group were significantly lower when compared to the control group. In addition, RTs group exhibited a significant reduction in neutrophil count and an elevation in lymphocyte count. Conclusion:Chronic exposure to radiation revealed a significant change in blood tests and may reflect an effect on RTs tissues, leading to serious health problems. However, further investigation in a large cohort to study the association between alteration in hematological parameters and chronic radiation exposure is required.

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Section: Discussionsupporting

confidence: 89%

Radiologic technologists in Saudi Arabia

Makkawi

Alasmari

Shubayr

et al. 2021

SMJ

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“…Long-Term X-Ray Exposure moglobin concentration (MCHC) and neutrophil decreased while only two parameters red blood cells (RBC) and lymphocytes increased after exposure to low-dose long-term natural terrestrial ionizing radiation [9]. There is a good match between our investigated results and this study since the significantly increasing value in lymphocytes of the x-ray technicians was observed.…”

Section: Wwwjbpeorgsupporting

confidence: 79%

The Effect of Long-Term X-Ray Exposure on Human Lymphocyte

Taqi

Faraj²,

Zaynal³

2018

J Biomed Phys Eng

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The aim of the paper is to investigate effects of long term x-ray exposure on the human lymphocyte, reactive lymphocyte parameters and morphology of lymphocytes in x-ray technicians at Kirkuk hospitals. The study included 54 apparently healthy male x-ray technicians were matched with another 54 apparently healthy control to show any alteration in the lymphocytes, reactive lymphocytes and morphology. The investigated samples were divide into two groups depending on the work experience and working hours per day. The samples were tested for hematological parameters by complete blood cells count (CBC). The results showed that strong significant (P<0.0001) increasing was recorded for the reactive lymphocytes in all groups of the diagnostic technicians compared with their controls and significantly increasing of lymphocytes observed for some groups. It was concluded that chronic exposure of x-ray can vary lymphocyte and reactive lymphocyte parameters significantly and working hours per day have discernible effects on lymphocyte morphology.

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“…In line with our findings, other studies have reported no association between exposure to low dose radiation and WBC (Forslund et al 1985 ; Heydarheydari et al 2012 ; Meo 2004 ; Salek Moghaddam et al 2004 ; Shafiee et al 2016a ; Zargan et al 2016 ), PLT (Heydarheydari et al 2012 , 2016 ; Sayed et al 2011 ; Shafiee et al 2016a ; Tavakkoli et al 2012 ; Zargan et al 2016 ), RBC (DavudianTalab et al 2018 ; Meo 2004 ; Mezhoud et al 2014 ; Shafiee et al 2016a ), MCH (Mezhoud et al 2014 ; Shafiee et al 2016a ), MCHC (Shafiee et al 2016a ), HCT (Hauck et al 2011 ; Mezhoud et al 2014 ; Shafiee et al 2016a ), HGB (Hauck et al 2011 ; Mezhoud et al 2014 ), and MCV levels (Mezhoud et al 2014 ). Nevertheless, statistically significant decreases in WBC (Davoudi et al 2012 ; Mezhoud et al 2014 ; Shahid et al 2015a ; Tavakkoli et al 2012 ), neutrophil (Shahid et al 2015a ; Taqi et al 2018 ), monocytes (Taqi et al 2018 ), basophile (Taqi et al 2018 ) lymphocytes (Sabagh and Chaparian 2019 ), PLT (Dainiak 2002 ; Davoudi et al 2012 ; Faraj and Mohammed 2018 ; Meo 2004 ; Mezhoud et al 2014 ; Sabagh and Chaparian 2019 ; Shafiee et al 2016b ; Shahid et al 2015a ; Taqi et al 2018 ), RBC (Abdolmaleki et al 2012 ; Heydarheydari et al 2016 ), HGB (Abdolmaleki et al 2012 ; Heydarheydari et al 2016 ; Shahid et al 2015a ), MCV (Abdolmaleki et al 2012 ; Heydarheydari et al 2016 ; Taqi et al 2018 ), RDW (Taqi et al 2018 ), HCT (Shahid et al 2015a ), MCH (Shahid et al ...…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, statistically significant decreases in WBC (Davoudi et al 2012 ; Mezhoud et al 2014 ; Shahid et al 2015a ; Tavakkoli et al 2012 ), neutrophil (Shahid et al 2015a ; Taqi et al 2018 ), monocytes (Taqi et al 2018 ), basophile (Taqi et al 2018 ) lymphocytes (Sabagh and Chaparian 2019 ), PLT (Dainiak 2002 ; Davoudi et al 2012 ; Faraj and Mohammed 2018 ; Meo 2004 ; Mezhoud et al 2014 ; Sabagh and Chaparian 2019 ; Shafiee et al 2016b ; Shahid et al 2015a ; Taqi et al 2018 ), RBC (Abdolmaleki et al 2012 ; Heydarheydari et al 2016 ), HGB (Abdolmaleki et al 2012 ; Heydarheydari et al 2016 ; Shahid et al 2015a ), MCV (Abdolmaleki et al 2012 ; Heydarheydari et al 2016 ; Taqi et al 2018 ), RDW (Taqi et al 2018 ), HCT (Shahid et al 2015a ), MCH (Shahid et al 2015a , 2014 ), and MCHC levels (Sabagh and Chaparian 2019 ; Shahid et al 2015a ) were reported in radiation workers compared with the control group. Also, the result of some studies yielded a significantly increased level of WBC (Nureddin and Alatta 2016 ), lymphocytes (Shahid et al 2015a ; Taqi et al 2018 ), PLT (Nureddin and Alatta 2016 ; Sayed et al 2011 ), RBC (Shahid et al 2015a ; Taqi et al 2018 ), MCV (Abdolmaleki et al 2012 ), HGB (Shahid et al 2015a ; Taqi et al 2018 ), and HCT (Sabagh and Chaparian 2019 ; Shahid et al 2015a ; Taqi et al 2018 ) in response to low-dose radiation. Several factors could explain these discrepancies and commonalities between previous literature and our findings, including study design, study sites, sample of study, characteristics of the participants (whether the radiation workers or control group), time of blood sampling, and other covariates (e.g., time and duration of exposure), and more importantly we cannot preclude the reporting bias that may cause some differences between findings.…”

Section: Discussionmentioning

confidence: 99%

Exposure to ionizing radiations and changes in blood cells and interleukin-6 in radiation workers

Asl

Islami-Seginsara

Kalan

et al. 2022

Environ Sci Pollut Res

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Long-term exposure to ionizing radiation (IR) can cause dire health consequences even less than the dose limits. Previous biomonitoring studies have focused more on complete blood counts (CBCs), with non-coherent results. In this study, we aimed to investigate the association between exposure to IR and cytokine interleukin-6 (IL-6) along with hematological parameters in Tabriz megacity’s radiation workers. In this hospital-based study, blood samples were taken from 33 radiation workers (exposed group) and 34 non-radiation workers (control group) in 4 hospitals. Absorbed radiation dose was measured by a personal film badge dosimeter in radiation workers. The studied biomarkers and all of the selected covariates were measured and analyzed using adjusted multiple linear regression models. The exposed doses for all radiation workers were under the dose limits (overall mean = 1.18 mSv/year). However, there was a significant association between exposure to ionizing radiation and IL-6 (49.78 vs 36.17; t = 2.4; p = 0.02) and eosinophils (0.17 vs 0.14; t = 2.02; p = 0.049). The difference between the mean of the other biomarkers in radiation workers was not statistically significant compared to the control group. This study demonstrated that long-term exposure to ionizing radiation, even under the dose limits, is related to a significantly increased level of some blood biomarkers (Il-6 and eosinophil) that, in turn, can cause subsequent health effects such as cancer.

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Impacts of Terrestrial Ionizing Radiation on the Hematopoietic System

Cited by 8 publications

References 72 publications

Radiologic technologists in Saudi Arabia

Radiologic technologists in Saudi Arabia

The Effect of Long-Term X-Ray Exposure on Human Lymphocyte

Exposure to ionizing radiations and changes in blood cells and interleukin-6 in radiation workers

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