Impacts of TCF7L2 gene polymorphisms on the susceptibility of hepatogenous diabetes and hepatocellular carcinoma in cirrhotic patients

Ling, Qi; Dong, Fengqin; Geng, Lei; Liu, Zhikun; Xie, Haiyang; Xu, Xiao

doi:10.1016/j.gene.2013.03.089

Cited by 23 publications

(22 citation statements)

References 31 publications

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“…In this SNP, we found that the rs290481TC and TC/CC genotype of TCF7L2 gene is relevant to increased susceptibility and progress of AEG. In additional, we also found that the potential association was more significant in BMI ≥24 kg/m 2 , which was in line with the findings of those studies mentioned above …”

Section: Discussionsupporting

confidence: 92%

“…The previous report showed that TCF7L2 rs290481 might influence the risik of HCC . Individuals carrying C rs290481 C rs290487 A rs290489 haplotype might have a significantly higher HCC susceptibility than those with T rs290481 T rs290487 G rs290489 . In this SNP, we found that the rs290481TC and TC/CC genotype of TCF7L2 gene is relevant to increased susceptibility and progress of AEG.…”

Section: Discussionmentioning

confidence: 48%

“…It is observed that TCF7L2 rs290481 polymorphism was positively associated with cancer susceptibility under the additive model . The previous report showed that TCF7L2 rs290481 might influence the risik of HCC . Individuals carrying C rs290481 C rs290487 A rs290489 haplotype might have a significantly higher HCC susceptibility than those with T rs290481 T rs290487 G rs290489 .…”

Section: Discussionmentioning

confidence: 94%

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Association of metabolism‐related genes polymorphisms with adenocarcinoma of the oesophagogastric junction: Evidence from 2261 subjects

Tang

Liu

Zhong

et al. 2019

J of Cellular Biochemistry

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The etiology of adenocarcinoma of the esophagogastric junction (AEG) remains unclear. It is believed that the increasing of AEG may be correlated with the elevated ratio of obesity and overweight. Thus, metabolism‐related genes and variants may play important roles in the occurrence and progress of AEG. The current investigation involved 720 patients with AEG and 1541 healthy controls. We selected transcription factor 7‐like 2 (TCF7L2) rs7903146 and rs290481, INS rs689 and INSR rs1799817 single‐nucleotide polymorphisms (SNPs), and explored the association of these SNPs with lymph node status and risk of AEG. The polymerase chain reaction was harnessed to identify the genotyping of four polymorphisms. We found that TCF7L2 rs290481 (T > C) and INSR rs1799817 (G > A) polymorphisms were associated with the increased susceptibility of AEG (P = .007 and 0.004 for TCF7L2 rs290481 in TC vs TT and TC/CC vs TT models, and P = .040 for INSR rs1799817 in GA/AA vs GG model). We also conducted a subgroup analysis by different cancer stage. We identified that TCF7L2 rs290481, INS rs689, and INSR rs1799817 SNPs increased the susceptibility of AEG in different cancer stage subgroups. In addition, we found that rs290481 SNP in TCF7L2 gene increased the risk of lymph node metastasis in drinking patients with AEG. However, the association of INSR rs1799817 SNP with a decreased risk of lymph node metastasis in smoking patients with AEG was found. Our findings highlight that TCF7L2 rs290481, INS rs689, and INSR rs1799817 polymorphisms may increase the risk of AEG. In addition, TCF7L2 rs290481 and INSR rs1799817 SNPs may influence the lymph node metastasis in patients with AEG.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 94%

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Association of metabolism‐related genes polymorphisms with adenocarcinoma of the oesophagogastric junction: Evidence from 2261 subjects

Tang

Liu

Zhong

et al. 2019

J of Cellular Biochemistry

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“…These results might suggest us that the haplotype might play important role in cancers. In other cancers, such as renal cancer [26], live cancer [16,20] and so on, the haplotype was definitely associated with cancer risk. As only one study showed the result of the haplotype of GHRL decreased breast cancer risk [10], and cancer is a mutifactorial disease, the more studies were needed to prove this phenomenon of haplotype with cancer risk.…”

Section: Discussionmentioning

confidence: 99%

No association of single nucleotide polymorphisms involved in GHRL and GHSR with cancer risk: A meta-analysis

Zhu¹,

Shao

Hao³

et al. 2015

CBM

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“…CNV-gene RHOA, downstream target of Wnt signaling, is a member of Rho family of small GTPases which were promising cellular targets for novel anticancer drugs [51]. CNV-gene TCF7L2 played a key role in Wnt signaling and was associated with susceptibility of hepatocellular carcinoma [52]. Two core members of Wnt family WNT9B and WNT3 were targeted by two CNV-TFs MZF1 and ZSCAN1 respectively.…”

Section: Resultsmentioning

confidence: 99%

Integrative Analysis of Transcriptional Regulatory Network and Copy Number Variation in Intrahepatic Cholangiocarcinoma

Lian

et al. 2014

PLoS ONE

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BackgroundTranscriptional regulatory network (TRN) is used to study conditional regulatory relationships between transcriptional factors and genes. However few studies have tried to integrate genomic variation information such as copy number variation (CNV) with TRN to find causal disturbances in a network. Intrahepatic cholangiocarcinoma (ICC) is the second most common hepatic carcinoma with high malignancy and poor prognosis. Research about ICC is relatively limited comparing to hepatocellular carcinoma, and there are no approved gene therapeutic targets yet.MethodWe first constructed TRN of ICC (ICC-TRN) using forward-and-reverse combined engineering method, and then integrated copy number variation information with ICC-TRN to select CNV-related modules and constructed CNV-ICC-TRN. We also integrated CNV-ICC-TRN with KEGG signaling pathways to investigate how CNV genes disturb signaling pathways. At last, unsupervised clustering method was applied to classify samples into distinct classes.ResultWe obtained CNV-ICC-TRN containing 33 modules which were enriched in ICC-related signaling pathways. Integrated analysis of the regulatory network and signaling pathways illustrated that CNV might interrupt signaling through locating on either genomic sites of nodes or regulators of nodes in a signaling pathway. In the end, expression profiles of nodes in CNV-ICC-TRN were used to cluster the ICC patients into two robust groups with distinct biological function features.ConclusionOur work represents a primary effort to construct TRN in ICC, also a primary effort to try to identify key transcriptional modules based on their involvement of genetic variations shown by gene copy number variations (CNV). This kind of approach may bring the traditional studies of TRN based only on expression data one step further to genetic disturbance. Such kind of approach can easily be extended to other disease samples with appropriate data.

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Impacts of TCF7L2 gene polymorphisms on the susceptibility of hepatogenous diabetes and hepatocellular carcinoma in cirrhotic patients

Cited by 23 publications

References 31 publications

Association of metabolism‐related genes polymorphisms with adenocarcinoma of the oesophagogastric junction: Evidence from 2261 subjects

Association of metabolism‐related genes polymorphisms with adenocarcinoma of the oesophagogastric junction: Evidence from 2261 subjects

No association of single nucleotide polymorphisms involved in GHRL and GHSR with cancer risk: A meta-analysis

Integrative Analysis of Transcriptional Regulatory Network and Copy Number Variation in Intrahepatic Cholangiocarcinoma

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