Impact of weight loss induced by gastric bypass or caloric restriction on oxidative stress and genomic damage in obese Zucker rats

Bankoglu, Ezgi Eyluel; Seyfried, Florian; Rotzinger, Laura; Nordbeck, Arno; Corteville, Caroline; Jurowich, Christian; Germer, Christoph T.; Otto, Christoph; Stopper, Helga

doi:10.1016/j.freeradbiomed.2016.02.033

Cited by 30 publications

(31 citation statements)

References 60 publications

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“…Oxidative stress was increased in ob/ob mice as evidenced by the elevated levels of 8-isoprostane together with the increase in the expression of the NADPH oxidase subunits Nox1 and Nox2 ( Cybb ) in WAT, which encode the major enzymes generating ROS 10 . These observations are in agreement with a large number of studies related to increased serum oxidative stress in obesity both in animal models and humans 10, 11, 39 . Leptin administration restored 8-isoprostane levels to normality and significantly reduced the expression of Nox1 and Cybb .…”

Section: Discussionsupporting

confidence: 92%

“…Leptin stimulates in vitro ROS production in different cell types 40, 41 and systemic oxidative stress in animal models 42 , suggesting a stimulatory role of leptin. On the contrary, oxidative stress is increased in obese Zucker fa/fa rats 39 , while leptin administration reduces the oxidative stress in different cellular 43 or rodent models 44, 45 . In the present study, exogenous administration of leptin to ob/ob mice repressed the increased expression of Nox1 and Cybb in WAT.…”

Section: Discussionmentioning

confidence: 94%

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Normalization of adiponectin concentrations by leptin replacement in ob/ob mice is accompanied by reductions in systemic oxidative stress and inflammation

Frühbeck

Catalán

Rodríguez

et al. 2017

Sci Rep

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The circulating concentrations of adiponectin, an antidiabetic adipokine, have been shown to be reduced in obesity, in relation to an increase in inflammation. The aim of the present work was to assess the effect of leptin replacement on adiponectin levels and expression as well as on markers of oxidative stress and inflammation in leptin-deficient ob/ob mice. Twelve-week-old male mice (n = 7–10 per group) were treated with either saline (wild type and ob/ob mice) or leptin (ob/ob mice) for 18 days. A third group of ob/ob mice was treated with saline and pair-fed to the amount of food consumed by the leptin-treated group. Leptin replacement restored values of adiponectin (P < 0.001), reduced circulating 8-isoprostane and serum amyloid A (SAA) levels (P < 0.05 for both), and significantly downregulated the increased gene expression of osteopontin (Spp1, P < 0.05), Saa3 (P < 0.05), Cd68 (P < 0.01), Il6 (P < 0.01) and NADPH oxidase (Nox1 and Nox2, P < 0.01) in the perirenal WAT and Spp1 (P < 0.05) in the liver of ob/ob mice. In cultured adipocytes from ob/ob mice, leptin increased (P < 0.05) the mRNA expression and secretion of adiponectin. We concluded that circulating concentrations of adiponectin are positively regulated by leptin and ameliorate obesity-associated oxidative stress and inflammation in mice.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 94%

Normalization of adiponectin concentrations by leptin replacement in ob/ob mice is accompanied by reductions in systemic oxidative stress and inflammation

Frühbeck

Catalán

Rodríguez

et al. 2017

Sci Rep

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“…Among all examined procedures [ 7 , 11 , 13 , 25 , 26 , 28 , 30 – 39 ], Roux-en-Y gastric bypass comprised over half (53.7%). The second most studied was sleeve gastrectomy (29.3%) [ 7 , 26 , 27 , 30 , 31 , 38 – 44 ].…”

Section: Resultsmentioning

confidence: 99%

“…Liquid chromatography coupled with mass spectrometry [ 7 , 11 , 13 , 25 , 30 – 32 , 41 – 44 , 48 , 50 , 51 ] and hydrogen nuclear magnetic resonance [ 11 , 26 , 33 , 35 , 37 – 40 , 45 – 47 , 49 ] were the most commonly used analytical platforms ( Figure 1 , Table 1 ). Gas chromatography was also a rather commonly used technique [ 7 , 27 , 28 , 34 – 37 , 42 , 44 , 52 ].…”

Section: Resultsmentioning

confidence: 99%

“…The history of bariatric surgery is dominated by six procedures, which are jejunoileal bypass (JIB), Roux-en-Y gastric bypass (RYGB), vertical-banded gastroplasty (VBG), biliopancreatic diversion (BPD) or its familiar duodenal switch (DS), adjustable gastric banding (AGB), and sleeve gastrectomy (SG) [ 3 , 6 ]. Nowadays, Roux-en-Y gastric bypass and sleeve gastrectomy are considered as the “gold standard” bariatric interventions [ 9 , 13 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Application of Metabolomics to Study Effects of Bariatric Surgery

Samczuk

Ciborowski

Krętowski

2018

Journal of Diabetes Research

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Bariatric surgery was born in the 1950s at the University of Minnesota. From this time, it continues to evolve and, by the same token, gives new or better possibilities to treat not only obesity but also associated comorbidities. Metabolomics is also a relatively young science discipline, and similarly, it shows great potential for the comprehensive study of the dynamic alterations of the metabolome. It has been widely used in medicine, biology studies, biomarker discovery, and prognostic evaluations. Currently, several dozen metabolomics studies were performed to study the effects of bariatric surgery. LC-MS and NMR are the most frequently used techniques to study main effects of RYGB or SG. Research has yield many interesting results involving not only clinical parameters but also molecular modulations. Detected changes pertain to amino acid, lipids, carbohydrates, or gut microbiota alterations. It proves that including bariatric surgery to metabolic surgery is warranted. However, many molecular modulations after those procedures remain unexplained. Therefore, application of metabolomics to study this field seems to be a proper solution. New findings can suggest new directions of surgery technics modifications, contribute to broadening knowledge about obesity and diseases related to it, and perhaps develop nonsurgical methods of treatment in the future.

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Does Bariatric Surgery Improve Obesity Associated Comorbid Conditions

Engin

2017

Obesity and Lipotoxicity

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Obesity is a constantly growing health problem which reduces quality of life and life expectancy. Bariatric surgery for obesity is taken into account when all other conservative treatment modalities have failed. Comparison of the multidisciplinary programs with bariatric surgery regarding to weight loss showed that substantial and durable weight reduction have been achieved only with bariatric surgical treatments. However, the benefits of weight loss following bariatric procedures are still debated regarding the pro-inflammatory and metabolic profile of obesity.

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Impact of weight loss induced by gastric bypass or caloric restriction on oxidative stress and genomic damage in obese Zucker rats

Cited by 30 publications

References 60 publications

Normalization of adiponectin concentrations by leptin replacement in ob/ob mice is accompanied by reductions in systemic oxidative stress and inflammation

Normalization of adiponectin concentrations by leptin replacement in ob/ob mice is accompanied by reductions in systemic oxidative stress and inflammation

Application of Metabolomics to Study Effects of Bariatric Surgery

Does Bariatric Surgery Improve Obesity Associated Comorbid Conditions

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