Impact of solid carriers and spray drying on pre/post-compression properties, dissolution rate and bioavailability of solid self-nanoemulsifying drug delivery system loaded with simvastatin

Sharma, Parth; Singh, Sachin Kumar; Pandey, Narendra Kumar; Rajesh, Sarvi Yadav; Bawa, Palak; Kumar, Bimlesh; Gulati, Monica; Verma, Shrish; Yadav, Ankit; Wadhwa, Sheetu; Jain, Subheet Kumar; Kuppusamy, Gowthamarajan; Malik, Adil Hussain; Gupta, Suksham; Khursheed, Rubiya

doi:10.1016/j.powtec.2018.07.092

Cited by 40 publications

(11 citation statements)

References 38 publications

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“…SMEDDS can be used as an excellent carrier for hydrophobic, poor absorbing and easily hydrolyzable drugs [19,20]. In recent years, SMEDDS has been extensively investigated for improving the oral bioavailability of unstable and water insoluble drugs, such as Ligusticum chuanxiong oil [21], curcumin [22], resveratrol [23] and simvastatin [24]. To the best of our knowledge, the formulation of phillygenin-loaded self-microemulsifying drug delivery system (PG-SMEDDS) has not been developed.…”

Section: Introductionmentioning

confidence: 99%

Self-Microemulsifying Drug Delivery System of Phillygenin: Formulation Development, Characterization and Pharmacokinetic Evaluation

et al. 2020

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Phillygenin, as an active ingredient of Forsythia suspensa, possesses a wide range of biological and pharmacological activity. However, its development and application are restricted due to its poor bioavailability and low solubility. Our work aimed to develop a self-microemulsifying drug delivery system to improve the oral bioavailability of phillygenin. The composition of the self-microemulsifying drug delivery system was preliminary screened by the pseudo-ternary phase diagram. Subsequently, the central composite design method was employed to optimize the prescription of the self-microemulsifying drug delivery system loaded with phillygenin. The prepared self-microemulsifying drug delivery system of phillygenin was characterized in terms of morphology, droplet size distribution, polydispersity index and stability. Then, the in vitro dissolution and the oral bioavailability were analyzed. The optimized self-microemulsifying drug delivery system of phillygenin consisted of 27.8% Labrafil M1944CS, 33.6% Cremophor EL, 38.6% polyethylene glycol 400 (PEG-400) and 10.2 mg/g phillygenin loading. The prepared self-microemulsifying drug delivery system of phillygenin exhibited spherical and uniform droplets with small size (40.11 ± 0.74 nm) and satisfactory stability. The in vitro dissolution experiment indicated that the cumulative dissolution rate of the self-microemulsifying drug delivery system of phillygenin was significantly better than that of free phillygenin. Furthermore, after oral administration in rats, the bioavailability of phillygenin was significantly enhanced by the self-microemulsifying drug delivery system. The relative bioavailability of the self-microemulsifying drug delivery system of phillygenin was 588.7% compared to the phillygenin suspension. These findings suggest that the self-microemulsifying drug delivery system of phillygenin can be a promising oral drug delivery system to improve the absorption of phillygenin.

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Section: Introductionmentioning

confidence: 99%

Self-Microemulsifying Drug Delivery System of Phillygenin: Formulation Development, Characterization and Pharmacokinetic Evaluation

et al. 2020

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“…The triplicate recording of particle size and zeta potential of formulation was performed on Malvern Zetasizer ZS200 and the mean value was recorded. After proper dilution, the formulation was transferred to polystyrene cuvettes and analyzed by passing laser light at an angle of 90 degrees and a voltage of 50 mV (Rajesh et al, 2018; Sharma et al, 2018).…”

Section: Methodsmentioning

confidence: 99%

Quality by design‐based optimization of formulation and process parameters for berberine nanosuspension for enhancing its dissolution rate, bioavailability, and cardioprotective activity

Alsabeelah

Kumar²

2022

Journal of Food Biochemistry

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Berberine (BER) is a natural alkaloid that is extracted from the root and bark of Berberis aristata (family Berberidaceae). It is commonly known as "Daru haldi" in Urdu. In traditional Chinese medicine and Ayurveda, BER formulations are widely used to treat illnesses like hypertension, and inflammatory conditions. BER has also been extensively explored for many pharmacological activities such as anti-arrhythmic, antimalarial, anticancer, anti-hyperglycemic, antioxidant, hepatoprotective, and antimicrobial activities (Behl et al., 2022). However, its poor aqueous solubility impediments its dissolution rate and oral bioavailability, which limits its clinical use (Sahibzada et al., 2018). To overcome these

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“…3 Transdermal route of drug delivery, hence appears to be a good alternative approach instead of oral route as it eliminates chances of drug loss by hepatic metabolism and even provides better patient compliance as opposed to other routes like parenteral route. 4,5 Topical route is not new to human beings as it has been in constant use for cosmetics and topical medications but the word transdermal appeared in 1944 when Webster introduced it as a route of drug delivery. 6 Transdermal patch is a self-contained dosage that is applied to intact skin and provides drug in a controlled manner.…”

Section: Introductionmentioning

confidence: 99%

Recent advancements in transdermal patches

Sharma

Thakur

Kaur

et al. 2022

ijhs

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Transdermal route of drug administration is novel as well as reliable means of sustained drug delivery. With more and more research being carried out in this field and increasing interest of researchers in this form of drug delivery, number of transdermal devices reaching the marketplace are expected to increase sharply. The aim of this review is to present latest explorations carried out in recent years utilizing possible drug candidates. Also, new polymer candidates along with novel penetration enhancers have been presented. For the purpose of study, various databases viz. Sciencedirect, Web of Knowledge, Pubmed, Google Scholar, etc. have been explored. After going through all the research work done by researchers in recent past it is appropriate to state that transdermal route is no longer reliant on few polymers and penetration enhancers but studies have now provided lot many more options for transdermal device formulation as evident from the data compilations. It can be concluded that most of the researchers have been utilizing HPMC as the preferred film forming polymer but recently use of Eudragit grades also has gained interest amongst scientists.

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Impact of solid carriers and spray drying on pre/post-compression properties, dissolution rate and bioavailability of solid self-nanoemulsifying drug delivery system loaded with simvastatin

Cited by 40 publications

References 38 publications

Self-Microemulsifying Drug Delivery System of Phillygenin: Formulation Development, Characterization and Pharmacokinetic Evaluation

Self-Microemulsifying Drug Delivery System of Phillygenin: Formulation Development, Characterization and Pharmacokinetic Evaluation

Quality by design‐based optimization of formulation and process parameters for berberine nanosuspension for enhancing its dissolution rate, bioavailability, and cardioprotective activity

Recent advancements in transdermal patches

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