Impact of socio-economic features on the prosthesis type choice used on heart surgery

Fernandes, André Maurício Souza; Bitencourt, Larissa Santana; Lessa, Igor Nogueira; Viana, Agnaldo; Pereira, Felipe; Bastos, Gabriel; Macedo, Cristiano; Júnior, Raimundo Alves Barrêto

doi:10.5935/1678-9741.20120036

Cited by 4 publications

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“…Most of the patients undergoing valve replacement were women younger than 50 years, which was also found before 18. Developing countries present a major chance of socioeconomic losses since valvulopathies usually affect young age individuals in their full working abilities 19.…”

Section: Discussionmentioning

confidence: 89%

In situ detection of Chlamydia pneumoniae, C. trachomatis, and cytokines among cardiovascular diseased patients from the Amazon region of Brazil

Freitas

Almeida

Queiroz

et al. 2017

IDR

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BackgroundChronic coronary artery disease has been associated, as a consequence of the local inflammatory reaction with previous or persistent infection with Chlamydia pneumoniae, which led to the investigation of the association of cardiovascular disease and previous infection with C. trachomatis and the role of cytokine profile (in situ) markers in the vascular system tissues.MethodsSixty-nine biopsies were collected for immunohistochemical analysis for the presence of IL-6, IL-8, TNF-α, IFN-γ, TGF-β, and IL-10, in 16 fragments from atheromatous plaques, 32 aorta fragments, and 21 valve fragments, using a tissue microarray technique for paraffin embedded tissues.ResultsMost patients undergoing revascularization surgery were men >50 years, while those undergoing valve replacement were mostly women <50 years. TNF-α was the most prevalent marker, detected in 91.7% (55/60) of the samples. The mean percent area stained was greater in patients infected with C. pneumoniae (3.81% vs 1.92%; p=0.0115) and specifically in the aorta (4.83% vs 2.25%; p=0.0025); C. trachomatis infection was higher in valves, and C. pneumoniae in plaques, both without statistical significance. There was no significant difference in the cytokine staining profile between patients previously infected with both species and uninfected patients.ConclusionAlthough there was no difference in the cytokine profile between patients previously infected with both species of Chlamydia, and uninfected patients, the presence of the bacteria antigens in the three biological specimens indicates it is important to focus on the role of C. trachomatis. It is necessary to improve the understanding of the natural history of chronic coronary artery disease and the clinical history of the patients and cytokine dynamics in cardiac disease in the presence or absence of infectious agents.

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Section: Discussionmentioning

confidence: 89%

In situ detection of Chlamydia pneumoniae, C. trachomatis, and cytokines among cardiovascular diseased patients from the Amazon region of Brazil

Freitas

Almeida

Queiroz

et al. 2017

IDR

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“…This study shows that the most frequent injury was the valve regurgitation (66.2%) followed by double lesion (25.9%) and stenosis (7.9%), in disagreement with the literature where it is shown a prevalence of stenotic lesions . However, this is a difficult comparison to make due to the scarcity of data on the prevalence of specific lesions, especially in rheumatic disease [ 18 ] .…”

Section: Discussionmentioning

confidence: 99%

Influence of valve prosthesis type on early mortality in patients undergoing valve surgery

Fernandes¹,

Pereira²,

Bitencourt³

et al. 2014

Revista Brasileira De Cirurgia Cardiovascular

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ObjectiveTo evaluate the influence of the type of prosthesis in-hospital mortality in the post-operative period in patients who had valve replacement.MethodsA cross-sectional data, such as gender, origin, age, etiology, echocardiograph data, the type of surgery performed and the prosthesis used in cases of valve replacement were analyzed retrospectively.ResultsWe reviewed 353 charts of patients who underwent valve replacement surgery. The mean age was 41.87±17.9 years. Regarding gender, 52.8% were female. As for the origin, 61.1% came from small cities within the state. Of all patients, 58.5% suffered from rheumatic disease. Assessing the type of prosthesis implanted, 70% held replace by bioprosthesis and 30% metallic. The hospital mortality in this study was 11%, with no significant difference between the types of prosthesis utilized.ConclusionThe type of implant used had no effect on in-hospital mortality.

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“…These abnormalities may be caused by congenital diseases or by a variety of acquired diseases that result in valvular stenosis, valvular insufficiency, or both. 1 …”

Section: Introductionmentioning

confidence: 99%

Molecular Analysis of Oral Bacteria in Heart Valve of Patients With Cardiovascular Disease by Real-Time Polymerase Chain Reaction

et al. 2015

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Structural deficiencies and functional abnormalities of heart valves represent an important cause of cardiovascular morbidity and mortality, and a number of diseases, such as aortic stenosis, have been recently associated with infectious agents. This study aimed to analyze oral bacteria in dental plaque, saliva, and cardiac valves of patients with cardiovascular disease. Samples of supragingival plaque, subgingival plaque, saliva, and cardiac valve tissue were collected from 42 patients with heart valve disease. Molecular analysis of Streptococcus mutans, Prevotella intermedia, Porphyromonas gingivalis, and Treponema denticola was performed through real-time PCR. The micro-organism most frequently detected in heart valve samples was the S. mutans (89.3%), followed by P. intermedia (19.1%), P. gingivalis (4.2%), and T. denticola (2.1%). The mean decayed, missing, filled teeth (DMFT) was 26.4 ± 6.9 (mean ± SD), and according to the highest score of periodontal disease observed for each patient, periodontal pockets > 4 mm and dental calculus were detected in 43.4% and 34.7% of patients, respectively. In conclusion, oral bacteria, especially S. mutans, were found in the cardiac valve samples of patients with a high rate of caries and gingivitis/periodontitis.

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Impact of socio-economic features on the prosthesis type choice used on heart surgery

Abstract: Biological prostheses were used predominantly in younger. This might be possible due to a low social-economic status, avoiding metal valve implantation and the consequent anticoagulation therapy.

Cited by 4 publications

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In situ detection of<em> Chlamydia pneumoniae,</em> <em>C. trachomatis, </em>and cytokines among cardiovascular diseased patients from the Amazon region of Brazil

In situ detection of<em> Chlamydia pneumoniae,</em> <em>C. trachomatis, </em>and cytokines among cardiovascular diseased patients from the Amazon region of Brazil

Influence of valve prosthesis type on early mortality in patients undergoing valve surgery

Molecular Analysis of Oral Bacteria in Heart Valve of Patients With Cardiovascular Disease by Real-Time Polymerase Chain Reaction

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Impact of socio-economic features on the prosthesis type choice used on heart surgery

Abstract: Biological prostheses were used predominantly in younger. This might be possible due to a low social-economic status, avoiding metal valve implantation and the consequent anticoagulation therapy.

Cited by 4 publications

References 0 publications

In situ detection of<em> Chlamydia pneumoniae,</em>&nbsp;<em>C. trachomatis,&nbsp;</em>and cytokines among cardiovascular diseased patients from the Amazon region of Brazil

In situ detection of<em> Chlamydia pneumoniae,</em>&nbsp;<em>C. trachomatis,&nbsp;</em>and cytokines among cardiovascular diseased patients from the Amazon region of Brazil

Influence of valve prosthesis type on early mortality in patients undergoing valve surgery

Molecular Analysis of Oral Bacteria in Heart Valve of Patients With Cardiovascular Disease by Real-Time Polymerase Chain Reaction

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Product

Resources

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In situ detection of<em> Chlamydia pneumoniae,</em> <em>C. trachomatis, </em>and cytokines among cardiovascular diseased patients from the Amazon region of Brazil

In situ detection of<em> Chlamydia pneumoniae,</em> <em>C. trachomatis, </em>and cytokines among cardiovascular diseased patients from the Amazon region of Brazil