Impact of smoking on heavy metal contamination and DNA fragmentation

Ahmed, Amira; Aldubayan, Maha; Ahmed, Hatem Abdel Moniem; Refaat, Ahmed M.; Alsalloumi, Albatool S; Almasuood, Rawan A.; Elgharabawy, Rehab M.

doi:10.1007/s11356-020-11633-y

Cited by 9 publications

(11 citation statements)

References 21 publications

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“… 39 The findings of a newly published study on the impact of cigarette, hookah, and mixed smoking on sperm DNA fragmentation based on urinary samples among 60 men from Saudi Arabia showed a significantly elevated DNA fragmentation rate in all cigarette, hookah, and mixed smokers compared to the controls. 40 Despite the differences in the type of samples and study design, the results of our study were in line with the aforementioned study, suggesting the destructive role of any type of tobacco smoking on DNA apart from its tissue sources in the human body. It should be noted, however, that we used the SCD test in our study to evaluate SDF.…”

Section: Discussionsupporting

confidence: 89%

“…Additionally, in comparison with non-smokers, the smokers had an elevated percentage of spermatozoa with a higher histone (H2B) to protamine ratio, causing alterations in the sperm chromatin structure during the process of spermiogenesis, and subsequently reducing fertility. 43 The possible mechanism of hookah consumption on sperm DNA according to the results of this study and aforementioned studies 38 - 43 may be supported by affecting histone replacement with protamine in the process of spermatogenesis due to the protamine expression alternations, resulting in uncompleted sperm chromatin packaging and chromatin instability, and increasing the sperm DNA damage. Moreover, the increase in ROS production, such as MDA by-product, due to the use of hookah could induce the apoptosis pathway during spermatogenesis and may hurt the male fertility potential.…”

Section: Discussionsupporting

confidence: 52%

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Possible Harmful Effects of Smoking Hookah on Sperm DNA Fragmentation Index and Protamine Genes Expression in Normozoospermic Men

et al. 2023

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Objectives: In recent years, smoking water pipes or hookah has increased among adolescents in most countries. Although there is evidence in support of the negative effects of this type of smoking on human health, such as the increased risk of lung disease, little is known about the potential effects of hookah smoking on the male reproductive system, especially on the molecular aspects of sperm. Patients and methods: This cross-sectional study examined sperm DNA fragmentation index, protamine 1 and 2 (PRM1 and PRM2) genes expression, and oxidant status in normozoospermic hookah smokers in comparison with non-smoker controls. Results: Our results showed significantly higher rates of DNA fragmentation, protamine deficiency, and abnormal chromatin condensation in the spermatozoa of hookah smokers ( P < .0001). Also, protamine gene expression showed a remarkable decrease in hookah smokers (1.55 ± 2.54 and 0.33 ± 0.54) compared to the controls (3.49 ± 5.41 and 1.22 ± 1.96), although the reduction was not statistically significant ( P = .155 and P = .066, respectively). Moreover, a significantly higher level of semen MDA was observed in the case group compared to the controls (0.39 ± 1.04 vs 0.15 ± 0.21; P = .013). Conclusion: According to our study, although hookah smoking does not have a significant effect on sperm parameters, it may have deleterious effects on DNA integrity, oxidative status, and nuclear protein levels of spermatozoa.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 52%

Possible Harmful Effects of Smoking Hookah on Sperm DNA Fragmentation Index and Protamine Genes Expression in Normozoospermic Men

et al. 2023

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“…In addition, an association of total mercury was found among smokers, but not among nonsmokers. A previous study showed that the impact of smoking on heavy metal contamination (35,36), and our study also revealed that the level of total mercury was higher in smokers than in nonsmokers. Similar findings were observed among drinkers, which may be due to the higher concentration of metals according to our results.…”

Section: Discussionsupporting

confidence: 79%

The association of blood metals with latent tuberculosis infection among adults and adolescents

Wu,

Wang,

Tao

et al. 2023

Front. Nutr.

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ObjectiveWe aimed to investigate the relationship of metal exposure and latent tuberculosis infection (LTBI) among US adults and adolescents.MethodsParticipants from the National Health and Nutrition Examination Surveys (NHANES 2011 ~ 2012) were included. Multiple logistic regression models were used to explore the associations between metal exposure and LTBI. A total of 5,248 adults and 1,860 adolescents were included in the present analysis.ResultsFor adults, we only found a positive association between total mercury and LTBI (OR: 1.411; 95% CI: 1.164 ~ 1.710) when used as a continuous variable. Compared with Q1, Q4 increased the prevalence of LTBI (2.303; 1.455 ~ 3.644) when used as a quartile. The OR of total mercury and LTBI was higher among females (1.517; 1.009 ~ 2.279), individuals aged 45 ~ 64 (1.457; 1.060 ~ 2.002), and non-Hispanic White individuals (1.773; 1.316 ~ 2.388). A relationship was observed among only participants with obesity (1.553; 1.040 ~ 2.319) or underweight (1.380; 1.076 ~ 1.771), with college or above (1.645; 1.184 ~ 2.286), with PIR > 3.0 (1.701; 1.217 ~ 2.376), reported smoking (1.535; 1.235 ~ 1.907) and drinking (1.464; 1.232 ~ 1.739). For adolescents, blood manganese was positively associated with LTBI. The OR and 95% CIs for each one-unit increase in the log-transformed level of blood manganese with LTBI were 9.954 (1.389 ~ 71.344).ConclusionSignificant associations were observed in girls, aged ≥12 years and in the non-Hispanic white population. In conclusion, total mercury is associated with an increased prevalence of LTBI among adults and positive association between blood manganese and LTBI was observed among adolescents. Further studies should be conducted to verify the results and explore potential biological mechanisms.

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“…Heavy metals, including Cr, Al, Cd, and Pb, which were selected for study in this paper, interact with the human body through many proteins, genes, and DNA by losing one or many electrons and manufactured metals cations, which have many affinity sites to various macromolecules, and many tissues and body organs are also affected [6,17]. The current results for groups 1 and 2 (Tables 2 and 3) may also be due to the daily use of other cosmetics, food, or drinks, and previous research has indicated various kinds of food contamination and toxicity, including those that are manufactured or fresh [14,15,23,25,26,[32][33][34][35][36][37]. Hence, the human body's direct exposure to heavy metals from food, beverages, cosmetics, soil, air, tobacco, dust, and skin can affect internal biological systems depending upon the dose, leading to acute early effective and chronic accumulation, consequently, leading to various macromolecule infection and health issues, including deadly neurological, brain, liver, kidney, bone, skin, and other fetal diseases [1,38].…”

Section: Discussionmentioning

confidence: 78%

A Bio-Indicator Pilot Study Screening Selected Heavy Metals in Female Hair, Nails, and Serum from Lifestyle Cosmetic, Canned Food, and Manufactured Drink Choices

Hamouda

Felemban

2023

Molecules

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Lifestyles, genetic predispositions, environmental factors, and geographical regions are considered key factors of heavy metals initiatives related to health issues. Heavy metals enter the body via the environment, daily lifestyle, foods, beverages, cosmetics, and other products. The accumulation of heavy metals in the human body leads to neurological issues, carcinogenesis, failure of multiple organs in the body, and a reduction in sensitivity to treatment. We screened for Cr, Al, Pb, and Cd in selected foods, beverages, and cosmetics products depending on questionnaire outcomes from female volunteers. We also screened for Cr, Al, Pb, and Cd on hair, nails, and serum samples using inductively coupled plasma mass spectrometry (ICP-MS) from the same volunteers, and we analyzed the serum cholinesterase and complete blood picture (CBC). We performed an AutoDock study on Cr, Al, Pb, and Cd as potential ligands. Our results indicate that the most elevated heavy metal in the cosmetic sample was Al. In addition, in the food and beverages samples, it was Pb and Al, respectively. The results of the questionnaire showed that 71 percent of the female volunteers used the studied cosmetics, food, and beverages, which were contaminated with Cr, Al, Pb, and Cd, reflecting the high concentration of Cr, Al, Cd, and Pb in the three different types of biological samples of sera, nails, and hair of the same females, with 29 percent of the female volunteers not using the products in the studied samples. Our results also show an elevated level of cholinesterase in the serum of group 1 that was greater than group 2, and this result was confirmed by AutoDock. Moreover, the negative variation in the CBC result was compared with the reference ranges. Future studies should concentrate on the actions of these heavy metal contaminations and their potential health consequences for various human organs individually.

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Impact of smoking on heavy metal contamination and DNA fragmentation

Cited by 9 publications

References 21 publications

Possible Harmful Effects of Smoking Hookah on Sperm DNA Fragmentation Index and Protamine Genes Expression in Normozoospermic Men

Possible Harmful Effects of Smoking Hookah on Sperm DNA Fragmentation Index and Protamine Genes Expression in Normozoospermic Men

The association of blood metals with latent tuberculosis infection among adults and adolescents

A Bio-Indicator Pilot Study Screening Selected Heavy Metals in Female Hair, Nails, and Serum from Lifestyle Cosmetic, Canned Food, and Manufactured Drink Choices

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