Impact of serum tumor marker determination on the management of women with borderline ovarian tumors: Multivariate analysis of a French multicentre study

Poncelet, Christophe; Fauvet, R.; Yazbeck, Chadi; Coutant, Charles; Daraı̈, Émile

doi:10.1016/j.ejso.2010.07.004

Cited by 24 publications

(10 citation statements)

References 29 publications

(29 reference statements)

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“…21 and Poncelet et al. 23 also support our findings that the CA19-9 level significantly increased especially in mMOTs. Our univariate analysis showed that mBOT diagnosed by FS in patients with a CEA level above the cut-off value may be associated with an increased risk of underdiagnosis.…”

Section: Discussionsupporting

confidence: 89%

Factors associated with misdiagnosis of frozen section of mucinous borderline ovarian tumor

et al. 2018

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Objective This study was performed to investigate the diagnostic accuracy of frozen section (FS) of mucinous borderline ovarian tumors (mBOTs) and the diagnostic value of various risk factors for misdiagnosis. Methods Patients with either an FS or permanent pathologic diagnosis of mBOT were included. Optimum cut-off values for serum tumor markers and maximal tumor diameter were determined, and risk factors for underdiagnosis of mucinous malignant ovarian tumors (mMOTs) were evaluated. The sensitivity, specificity, Youden's index, and diagnostic odds ratio of the risk factors were assessed to determine their diagnostic value for mMOTs. Results Of 121 included patients, 97 were diagnosed with mBOTs by FS. Relatively abnormal cancer antigen 125 (CA125), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA) levels; bilateral tumors; and specific pathological features showed significant associations with underdiagnosis of mMOTs in the univariate analysis. The presence of specific pathological features was the only significant risk factor in the multivariate analysis. The CA125, CA19-9, and CEA levels and specific pathological features demonstrated certain diagnostic value in detecting malignant cases among FS-diagnosed mBOTs. Conclusions In patients with FS-diagnosed mBOT, significant predictors of malignancy were relatively higher CA125, CA19-9, and CEA levels; bilateral tumors; and tumors with specific pathological features.

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Section: Discussionsupporting

confidence: 89%

Factors associated with misdiagnosis of frozen section of mucinous borderline ovarian tumor

et al. 2018

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“…Indeed, women who had these assays were more likely to have radical treatment (p \ 0.0001), intraoperative histology (p \ 0.0001) and a complete staging (p \ 0.004) [72]. Elevated CA-125 is found in up to 61% of women with BOT, although this marker may have value in identifying suspected BOT; clinicians should be aware that the levels might overlap between women with BOT and those with stage I invasive ovarian cancers [7].…”

Section: Discussionmentioning

confidence: 98%

The preoperative diagnosis of borderline ovarian tumors: a review of current literature

Morotti

Menada

Gillott

et al. 2011

Arch Gynecol Obstet

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After completion of this article, the reader should be aware of the symptoms of BOTs, the potential role and pitfalls of tumor marker measurement. In addition, the reader will understand the appearance of BOTs at imaging techniques; the reader will be able to compare and combine ultrasonography, MRI and positron emission tomography in diagnosing BOTs. In clinical practice, the reader should be better able to assess whether an ovarian mass is a benign tumor, a BOT or an invasive cancer.

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“…In a study conducted in Singapore, Wong et al [21] have reported that the mean women's age at ovarian borderline tumors diagnosis was 38 years old, ranging from 16-89 years old. Another study developed in France have documented that one third of ovarian borderline tumors are diagnosed in women younger than 40 years old, and more than 80% of cases are detected early in an disease course [22]. Moreover, these tumors tend to affect women at a younger age than the typical EOCs in the USA [1].…”

Section: Discussionmentioning

confidence: 99%

A retrospective analysis of clinicopathological and prognostic characteristics of ovarian tumors in the State of Espírito Santo, Brazil

et al. 2011

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BackgroundOvarian cancer is sixth most common cancer among women and the leading cause of death in women with gynecological malignancies. Despite the great impact ovarian cancer has on women's health and its great impact in public economy, Brazil still lacks valuable information concerning epidemiological aspects of this diseaseMethodsWe've compiled clinical data of all ovarian tumors registered at the two public hospitals of reference (1997 - 2007), such as: patients' age at diagnosis, tumor histological type, tumor stage, chemotherapy regimens, chemotherapy responsiveness, disease-free survival, and overall survival.ResultsWomen's mean age at diagnosis was 54.67 ± 13.84 for ovarian cancer, 46.15 ± 11.15 for borderline tumors, and 42.01 ± 15.06 for adenomas. Among epithelial ovarian cancer cases, 30.1% were of serous, 13.7% were of mucinous, and 13.7% were of endometrioid type; exceptionally serous carcinoma was diagnosed in women younger than 30 years old. Endometrioid cancer had lower disease-free survival than others (p < 0.05). Cases were predominantly diagnosed as poor prognosis disease (FIGO III and IV, 56.2%). Regarding responsiveness to platinum-based therapy, 17.1% of patients were resistant, whereas 24.6%, susceptible. From these, we found equally responsiveness to platinum alone or its association with paclitaxel or cyclophosphamide.DiscussionOur data agreed with other studies regarding mean patients' age at diagnosis, histological type frequency, FIGO stages distribution, and chemotherapy regimens. However, the histological type distribution, with equal contribution of mucinous and endometrioid types seems to be a unique characteristic of the studied highly miscegenated population.ConclusionWe have enlighten the profile of the studied ovarian cancer population, which might enable the development of more efficient political strategies to control this malignancy that is the fifth leading cause of cancer-related deaths among women.

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Impact of serum tumor marker determination on the management of women with borderline ovarian tumors: Multivariate analysis of a French multicentre study

Cited by 24 publications

References 29 publications

Factors associated with misdiagnosis of frozen section of mucinous borderline ovarian tumor

Factors associated with misdiagnosis of frozen section of mucinous borderline ovarian tumor

The preoperative diagnosis of borderline ovarian tumors: a review of current literature

A retrospective analysis of clinicopathological and prognostic characteristics of ovarian tumors in the State of Espírito Santo, Brazil

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