A retrospective analysis of clinicopathological and prognostic characteristics of ovarian tumors in the State of Espírito Santo, Brazil

Abstract

BackgroundOvarian cancer is sixth most common cancer among women and the leading cause of death in women with gynecological malignancies. Despite the great impact ovarian cancer has on women's health and its great impact in public economy, Brazil still lacks valuable information concerning epidemiological aspects of this diseaseMethodsWe've compiled clinical data of all ovarian tumors registered at the two public hospitals of reference (1997 - 2007), such as: patients' age at diagnosis, tumor histological type, tumor stage, chemotherapy regimens, chemotherapy responsiveness, disease-free survival, and overall survival.ResultsWomen's mean age at diagnosis was 54.67 ± 13.84 for ovarian cancer, 46.15 ± 11.15 for borderline tumors, and 42.01 ± 15.06 for adenomas. Among epithelial ovarian cancer cases, 30.1% were of serous, 13.7% were of mucinous, and 13.7% were of endometrioid type; exceptionally serous carcinoma was diagnosed in women younger than 30 years old. Endometrioid cancer had lower disease-free survival than others (p < 0.05). Cases were predominantly diagnosed as poor prognosis disease (FIGO III and IV, 56.2%). Regarding responsiveness to platinum-based therapy, 17.1% of patients were resistant, whereas 24.6%, susceptible. From these, we found equally responsiveness to platinum alone or its association with paclitaxel or cyclophosphamide.DiscussionOur data agreed with other studies regarding mean patients' age at diagnosis, histological type frequency, FIGO stages distribution, and chemotherapy regimens. However, the histological type distribution, with equal contribution of mucinous and endometrioid types seems to be a unique characteristic of the studied highly miscegenated population.ConclusionWe have enlighten the profile of the studied ovarian cancer population, which might enable the development of more efficient political strategies to control this malignancy that is the fifth leading cause of cancer-related deaths among women.

nm23 gene polymorphisms are associated with survival of patients with epithelial ovarian cancer but not with susceptibility to disease

“…Although Kaplan-Meier analysis indicated that patients carrying the variant homozygous C/C genotype had shorter PFS and OS than those carrying the T allele (T/T + T/C genotype) for SNP rs16949649T/C, the Cox proportional hazard model analysis suggested that this relationship was only retained in the OS of patients when adjusted by clinical factors. The histological cell type, stage, and residual tumor size affect the survival of ovarian cancer patients [20][21][22]. The current study also confirmed that the age at diagnosis, FIGO stage, grade and residual tumor size were closely related to the survival time of patients with epithelial ovarian cancer.…”

Incidence, Histological Types and Age at Presentation of Borderline and Malignant Ovarian Tumors at a Tertiary Institute in Nepal

“…1 The Brazilian National Institute of Cancer describes epithelial ovarian cancer as a high mortality gynecological cancer. 2 According to the IARC Globocan 2012 data, the incidence of ovarian cancer is 3.6% behind breast, colorectal, cervix, lung, uterine and stomach cancer. 1 At Tribhuvan University Teaching Hospital based on hospital audit data, ovarian tumors are the most common type of genital malignancy and also the most common to undergo surgery.…”

Clinico pathological study of ovarian neoplasms

“…1 Ovarian cancer is the sixth most common cancer in women and the leading cause of death in women with gynecological malignancy. 2 Epithelial ovarian cancer is the ninth most common cancer among women 3 . Ovarian cancer rates increase exponentially with age.…”