The preoperative diagnosis of borderline ovarian tumors: a review of current literature

Morotti, Matteo; Menada, Mario Valenzano; Gillott, David J.; Venturini, Pier Luigi; Ferrero, Simone

doi:10.1007/s00404-011-2194-1

Cited by 39 publications

(26 citation statements)

References 75 publications

(174 reference statements)

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“…However, the clinical presentations of BOTs are not very specifi c. Radiological imaging studies and laboratory fi ndings are similar to that Correspondence: D. Basaran, Department of Obstetrics and Gynecology, Hacettepe University Faculty of Medicine, 06100, Sihhiye, Ankara, Turkey. E-mail: dermanbasaran@gmail.com of benign and malignant lesions (Morotti et al 2012). Th us, the accurate diagnosis of these neoplasms is based on histopathological examination, which highlights the importance of intraoperative FS analysis.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of intraoperative consultation (frozen section) in borderline ovarian tumours and factors associated with misdiagnosis

Başaran

Salman

Çalış³

et al. 2014

Journal of Obstetrics and Gynaecology

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The objective of our study was to evaluate the accuracy of frozen section (FS) in borderline ovarian tumours (BOT) and to define the factors associated with misdiagnosis during FS evaluation. We performed a retrospective review of patients who underwent exploratory laparotomy for an adnexal mass, from January 2007 to July 2012, at a tertiary oncology centre in Turkey. Patients with a diagnosis of BOT either in FS or in permanent pathology were identified. Agreement between FS diagnosis and permanent histology was observed in 37/59 patients (62.7%), which gave a sensitivity and a positive predictive value of 71.2% and 84.1%, respectively. In patients with a diagnosis of BOT by frozen section only (n = 44), the diagnosis was consistent with permanent histopathology in 37/44 patients (84.1%). Frozen section interpreted a malignant tumour as BOT (under-diagnosis) in 6/44 (13.6%) of cases and interpreted a benign lesion as BOT (over-diagnosis) in 1/44 (2.3%) of cases. Slide review of discrepant cases revealed that major pathological causes of under-diagnosis were misinterpretation and sampling errors. Univariate analysis showed that presence of bilateral tumour and positive peritoneal cytology were associated with under-diagnosis. We concluded that, despite significant risk of under-diagnosis, FS analysis is an accurate method for intraoperative diagnosis of BOTs.

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Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of intraoperative consultation (frozen section) in borderline ovarian tumours and factors associated with misdiagnosis

Başaran

Salman

Çalış³

et al. 2014

Journal of Obstetrics and Gynaecology

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“…It is important to preoperatively discriminate BOTs from invasive malignant tumors because a conservative fertilitysparing laparoscopic surgery can be performed in the former [27]. The preoperative diagnosis of BOTs remains challenging regarding the clinical, laboratory, and imaging findings [28]. Morphological imaging features suggesting borderline tumors have been investigated; however, there are overlapping with those of invasive epithelial tumors.…”

Section: Discussionmentioning

confidence: 99%

Functional MRI in the pre-operative assessment of GI-RADS 3, 4, and 5 ovarian masses

Ibrahim

Maher

Abdalaziz

et al. 2019

Egypt J Radiol Nucl Med

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Background: Characterization of an ovarian lesion is a diagnostic challenge. A correct preoperative assessment is of great importance so as to arrange adequate therapeutic procedures. The aim of the current study is to evaluate the diagnostic performance of functional MRI in differentiation between malignant, borderline, and benign ovarian masses. Results: This study included 56 adnexal lesions. Bilateral synchronous ovarian lesions are detected in 16 cases. Postoperative histologically proved to be benign in 17 (30%), borderline (low potential malignancy) in 12 (22%), and malignant in 27 (48%). The overall diagnostic performance of conventional MRI in the diagnosis of adenexal lesion was a sensitivity of 74%, specificity of 47%, positive predictive value (PPV) of 76%, negative predictive value (NPV) of 44%, and an accuracy of 66%. Functional pelvic MRI examination showed an increase in overall diagnostic performance compared to conventional values with the highest sensitivity of 90% and NPV of 67% using DWI, and the highest specificity of 88%, PPV of 94%, and an accuracy of 82% using DCE MRI. Conclusion: Functional MRI in conjugation with conventional MRI plays a key role in the ovarian lesion detection, characterization, and staging. Functional MRI is currently being evaluated as possible predictive and prognostic biomarkers in ovarian lesions.

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“…There are similarities with benign cystadenomas. Multiple cysts, solid sections, papillary structures, or septa are indicative of BOTs [7][8][9].…”

Section: Bots In Adultsmentioning

confidence: 99%

“…CA-125, CA 19.9, CEA, and CA 72-4 can be deployed as serum markers; however, they are only increased in a percentage of patients with BOTs (CA125 24-61%, CA 19.9 to 49%, CEA 17%, and CA 72-4 33%) [8].…”

Section: Bots In Adultsmentioning

confidence: 99%

Ovarian Borderline Tumors in Pre-Menarche Girls

Höhne

Milzsch

Stiefel

et al. 2013

Pediatric Hematology and Oncology

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By reason of a new case of an ovarian mucinous borderline tumor (BOT) in a pre-menarche girl, a research of current literature was implemented. Low-grade malignant epithelial tumors are extremely rare in young children and, as far as we know, only a few case reports exist. The patients presented with vomiting, pain, and a swollen lower abdomen. Pre-operative diagnosis primarily consists of imaging techniques. At Stage Ia, the tumor is confined to the ovary without penetration of the capsule, no malignant ascites or peritoneal implants. Treatment consists of removal of the tumor combined with concurrent salpingo oophorectomy, appendectomy, omentectomy, and peritoneal lavage. Although the treatment recommendations are not uniform, basically, preservation of fertility is the main objective. The prognosis is very good, but recurrence is possible even after 10 years.

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The preoperative diagnosis of borderline ovarian tumors: a review of current literature

Cited by 39 publications

References 75 publications

Diagnostic accuracy of intraoperative consultation (frozen section) in borderline ovarian tumours and factors associated with misdiagnosis

Diagnostic accuracy of intraoperative consultation (frozen section) in borderline ovarian tumours and factors associated with misdiagnosis

Functional MRI in the pre-operative assessment of GI-RADS 3, 4, and 5 ovarian masses

Ovarian Borderline Tumors in Pre-Menarche Girls

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