Impact of season on antioxidants, nutritional metabolic status, cortisol and heat shock proteins in Hariana and Sahiwal cattle

Kumar, Jitender; Madan, Arun Kumar; Kumar, Muneender; Sirohi, Rajneesh; Yadav, Brijesh; Reddy, A. Vidyasagar; Swain, Dilip Kumar

doi:10.1080/09291016.2017.1332842

Cited by 26 publications

(25 citation statements)

References 19 publications

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“…Higher antioxidants concentrations contributed to delaying or reducing the protein oxidation processes [58]. The current decrease of antioxidant activity on days −14 and 0 is consistent with Kumar et al [59]. They attributed this decrease to increased energy demand and lipolysis of body reserves, which leads to elevated free radical production and reduced antioxidant activity.…”

Section: Discussionsupporting

confidence: 86%

Peri-parturient hypocalcemia in goats: Clinical, hematobiochemical profiles and ultrasonographic measurements of postpartum uterine involution

et al. 2021

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Background and Aim: Hypocalcemia in goats occurs around the time of parturition and is caused by decreasing level of calcium less than 10 mg/dL. This investigation characterized the hematological and biochemical profiles of peri-parturient hypocalcemia in goats and study the effects of hypocalcemia on uterine involution during the postpartum period on day 0 and then weekly postpartum (day +7, +14, +21, +28, +35, till +42). Materials and Methods: Forty-five polyparous native breed does age 3-5 years and weighing 40–60 kg were assigned to control and hypocalcemia groups based on their health history, clinical and biochemical findings. The control group included 10 clinically healthy pregnant does, and the hypocalcemia group included 35 late pregnant does that suffered from anorexia, weakness, muscle tremors of the hind limbs, and an inability to stand. Clinical examination and blood sampling in both groups were performed approximately 14 days before the expected time of kidding (day–14), at kidding day (day 0), on day +21, and +42 postpartum. Sonographic measurements were used to monitor uterine involution on day 0 and then weekly once the animal was postpartum (day +7, +14, +21, +28, +35, till +42) in both groups. Results: Results of sonographic measurement revealed that the hypocalcemia group had a greater (p<0.05) size of the uterus as assessed transrectally and retarded uterine involution when compared with the control group. Laboratory findings revealed that does in both groups showed lower red blood cells, packed cell volume%, and hemoglobin (Hb) concentrations on day –14 before kidding and day 0 when compared with postpartum measurements. A significant increase (p<0.05) in total leukocyte counts, neutrophil, serum glucose, and cortisol levels with a significant decrease (p<0.05) in lymphocytes. Significant decreases (p<0.05) in serum calcium, phosphorous, vitamin D, and total antioxidant capacity levels with significant (p<0.05) increases in serum malondialdehyde were recorded on day 0 and day –14 in the hypocalcemia group when compared with the control group. Conclusion: This investigation provides evidence that hypocalcemia in does causes both metabolic and oxidative stress during peri-parturient periods while also retarding uterine involution during postpartum periods.

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Section: Discussionsupporting

confidence: 86%

Peri-parturient hypocalcemia in goats: Clinical, hematobiochemical profiles and ultrasonographic measurements of postpartum uterine involution

et al. 2021

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“…Exposure to heat stress during the hottest season causes the oxidant/antioxidant imbalance ( 23 , 28 ). Heat stress also causes a reduction in plasma antioxidant activity increasing the production of free radicals and decreasing endogenous synthesis of antioxidants ( 23 , 24 ). Measuring the antioxidant and oxidant activities is very important to evaluate the effect of summer high ambient temperature ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

“…High levels of glucocorticoids have decreased blood glutathione and erythrocyte superoxide dismutase activity in rats ( 7 , 31 ), goats ( 3 ), and cows ( 28 ). Some authors pointed out the increased oxidant and decreased antioxidant activity during the summer months ( 6 , 23 , 28 ). Heat stressed cows had lower total antioxidants after calving during summer than those calving in winter ( 42 ).…”

Section: Discussionmentioning

confidence: 99%

“…However, heat stress during the summer period significantly affects bovine physiology causing a decrease in feed intake and increasing body temperature. This can result in increased energy demand and lipolyses of body reserves, which leads to elevated free radicals production and reduced antioxidant activity ( 8 , 23 ). The data obtained in the current study indicated that blood GSH-Px activity and MDA levels in cows would be influenced by seasonal variations (temperature and humidity) during the transition period and the summer group had more oxidative stress compared to cows in winter.…”

Section: Discussionmentioning

confidence: 99%

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MDA and GSH-Px activity in transition dairy cows under seasonal variations and their relationship with reproductive performance

Çolakoğlu

Yazlık

Kaya

et al. 2017

Journal of Veterinary Research

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IntroductionThe purpose of the current study was to evaluate the blood glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) levels under seasonal variations in dairy cows during transition period, and to assess the relationship between chosen reproductive parameters, GSH-Px, and MDA.Material and MethodsHolstein cows calving in January were assigned into winter group (n = 42), while cows calving in August were assigned into summer group (n = 42). Blood samples were collected from the jugular vein 21, 14, and 7 days before calving, at calving (0 day), and 7, 14, and 21 days after calving. Reproductive parameters obtained from farm records were evaluated.ResultsIn both groups of cows, GSH-Px activity decreased from 21 days before calving to day 0, and it gradually continued to increase until 21 days after calving. GSH-Px activity was higher in winter group compared to summer group during the transition period (P < 0.05). MDA levels in both groups increased over time starting from 21 days before calving to 0 day, but it gradually decreased thereafter. MDA levels were higher in summer group compared to winter group during the transition periods (P < 0.05). Summer group of cows showed higher intervals of calving-to-oestrus, calving-to-conception, and higher insemination index (P < 0.01). Negative correlation was recorded between GSH-Px and MDA during all examination days (P < 0.01). MDA levels correlated with calving to conception interval on day 21 before calving and day 0 (P < 0.01) and insemination index on day 0 and 21 days after calving (P < 0.01). GSH-Px activity was negatively correlated with calving to conception interval on day 21 before calving, day 0, and 21 days (P < 0.01) after calving. Negative correlation on day 21 before calving and day 0 was also determined between GSH-Px and insemination index (P < 0.01).ConclusionThis study showed that blood oxidant and antioxidant levels have affected the fertility parameters in cows under seasonal variations.

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“…These data indicate that the HTHI and LTHI condition impaired antioxidant capacity and thus induced oxidative stress. The previous study of dairy cows reported the expression of HSP70 was increased under heat stress (THI = 86.83) and was reduced in cold stress (THI = 60.52) ( Kumar et al., 2018 ). Similar results in HSP70 were also observed in dairy cows exposed to HTHI (86.09) and LTHI (42.97) in this study.…”

Section: Discussionmentioning

confidence: 99%

Effect of seasonal thermal stress on oxidative status, immune response and stress hormones of lactating dairy cows

Liang

Zhang

et al. 2021

Animal Nutrition

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This study aimed to assess the impact of seasonal thermal stress on oxidative stress, immune response, and stress hormones of lactating dairy cows in subtropical regions with different levels of temperature-humidity index (THI). A total of 32 healthy lactating Holstein dairy cows experienced 4 seasons (8 cows/season). The physiological parameters were categorized into low THI (LTHI, THI = 42.97 ± 0.95) in winter, moderate THI (MTHI, THI = 61.84 ± 0.42) in spring and autumn, and high THI period (HTHI, THI = 86.09 ± 0.23) in summer. The blood samples were collected twice in each season to measure oxidative stress, inflammatory and hormonal parameters. Our results showed THI had a positive correlation with the rectal temperature ( R 2 = 0.821, P < 0.001) and respiratory rate ( R 2 = 0.816, P < 0.001). Dry matter intake, milk yield and fat percentage also significantly differed among groups ( P < 0.05). Compared with the MTHI group, the LTHI group exhibited a significant increase in malondialdehyde (MDA) level ( P < 0.001), and the HTHI group displayed a significant increase in levels of cortisol, interleukin (IL)-10, IL-1β and tumor necrosis factor-α ( P < 0.001). Opposite changes in serum endotoxin and immunoglobulin G levels were observed with the increasing THI ( P < 0.001). LTHI notably increased the triiodothyronine level, although the thyroxine level was reduced by LTHI and HTHI compared with the MTHI group. In conclusion, LTHI and HTHI conditions may induce different degrees of oxidative stress, inflammation response, and stress hormone imbalances on lactating dairy cows, therefore environmental management is necessary for the health of dairy cows in extreme weather conditions.

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Impact of season on antioxidants, nutritional metabolic status, cortisol and heat shock proteins in Hariana and Sahiwal cattle

Cited by 26 publications

References 19 publications

Peri-parturient hypocalcemia in goats: Clinical, hematobiochemical profiles and ultrasonographic measurements of postpartum uterine involution

Peri-parturient hypocalcemia in goats: Clinical, hematobiochemical profiles and ultrasonographic measurements of postpartum uterine involution

MDA and GSH-Px activity in transition dairy cows under seasonal variations and their relationship with reproductive performance

Effect of seasonal thermal stress on oxidative status, immune response and stress hormones of lactating dairy cows

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