MDA and GSH-Px activity in transition dairy cows under seasonal variations and their relationship with reproductive performance

Çolakoğlu, Hatice Esra; Yazlık, Murat Onur; Kaya, Ufuk; Çolakoğlu, Ekrem Çağatay; Kurt, Serdal; Öz, Burcu; Bayramoglu, Rustem; Vural, Mehmet Rıfat; Küplülü, Şükrü

doi:10.1515/jvetres-2017-0067

Cited by 39 publications

(29 citation statements)

References 39 publications

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“…The present study results showed low GSH-Px activity in cows with low-BCS during the transition period. Additionally, higher GSH-Px activity, in both groups, was found at prepartum period than after calving, similar to reports by Colakoglu et al (2017) and Festila et al (2012). As in MDA concentrations, the discrepancies in relative GSH-Px activity may be related to sampling time and BCS point used in groups of the studies.…”

Section: Discussionsupporting

confidence: 91%

Relationship between body condition score, blood metabolites and oxidative stress in transition period and reproductive performance of dairy cows

Çolakoğlu

Yazlık

Kaya

et al. 2020

J Hellenic Vet Med Soc

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The aim of the current study was to investigate the relationship between prepartum body condition score (BCS), blood metabolites (Glucose, beta-hydroxybutyrate; BHB), oxidative stress (Malondialdehyde; MDA, Glutathione peroxidase; GSH-Px) in transition period and some reproductive parameters in Holstein dairy cows. Fifty cows were divided into two groups [low-BCS = 2.75-3.0 (n=25); adequate-BCS = 3.25-3.75 (n=25)] according to BCS on the 21st day before expected calving. BCS was also recorded at 0 and +21 days after calving. Blood samples collected at -21, 0 and +21 days from calving for MDA and GSH-Px analysis as well as at -21, +14 and +21 days of postpartum for glucose and BHB. Data on reproductive parameters obtained from farm records were also collected. MDA concentrations were higher in group of low-BCS compared to group of adequate-BCS at -21 and 0 d related to calving (p<0.05). GSH-Px activity was lower in group of low-BCS than adequate one during the transition period (p<0.05). Low-BCS group also showed higher concentrations of BHB at +14 and +21 days after calving. During the transition period, low-BCS group had lower glucose concentrations compared to adequate one (p<0.05). Adequate-BCS group of cows showed shorter intervals of calving to first estrus (p<0.01) and calving to conception (p<0.01). In conclusion, cows with lower BCS at the prepartum period had worse metabolic and oxidative balance during the transition period. This situation also was associated with worse reproductive performance in cows.

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Section: Discussionsupporting

confidence: 91%

Relationship between body condition score, blood metabolites and oxidative stress in transition period and reproductive performance of dairy cows

Çolakoğlu

Yazlık

Kaya

et al. 2020

J Hellenic Vet Med Soc

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“…Malondialdehyde is the final product of lipid peroxidation, a process that occurs as a consequence of oxidative stress [18,38]. Although the values here reported are in the middle of the range of those previously reported for dairy cows during the transition period [39][40][41][42][43], they followed a similar pattern, characterized by a significant increase in the first two weeks after calving. These results suggest that both groups experienced limited degrees of oxidative stress, and cows in the HFM group were increasingly exposed to oxidative damage during the second week postpartum.…”

Section: Discussionsupporting

confidence: 56%

Prepartum Fat Mobilization in Dairy Cows with Equal Body Condition and Its Impact on Health, Behavior, Milk Production and Fertility during Lactation

Rodríguez

Mellado

Bustamante

2020

Animals

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The objective of this study was to evaluate the effect of two levels of fat mobilization at the close-up period in dairy cows with an equal body condition score (BCS = 3.0) on the circulating concentrations of metabolic, inflammatory, and oxidative stress biomarkers, incidence of diseases, behavior, milk production, and fertility during the postpartum. Late-gestation multiparous Holstein cows (n = 59) with a body condition score of 3.0 (5-point scale) were enrolled at the beginning of the close-up period and then were followed during the entire lactation. Cows were retrospectively allocated into two groups: animals with prepartum non-esterified fatty acids concentration over 0.3 mmol/L were categorized as high fat mobilization (HFM) (n = 26), and below this threshold as low fat mobilization (LFM) (n = 33). Blood samples were collected 21 d before expected calving and once weekly for 3 wk postpartum in order to analyze β-hydroxybutirate, haptoglobin, fibrinogen, total proteins, and malondialdehyde. Health was observed daily for 21 d postpartum. Behavioral data was collected with an accelerometer and milk production and fertility were obtained from the farm records. An increased fat mobilization in dairy cows with equal BCS modified the inflammatory and oxidative stress responses during the early postpartum without impairing their health status and fertility. Moreover, milk production and behavior were markedly affected by excessive prepartum fat mobilization through lactation.

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“…[ 14 ] and Colakoglu et al . [ 5 ] concerning MDA concentration measured during early puerperium and late puerperium until mid-lactation. All previous studies agree that significant changes in oxidative stress are observed, especially during the transition period [ 5 , 14 , 15 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…[ 5 ] concerning MDA concentration measured during early puerperium and late puerperium until mid-lactation. All previous studies agree that significant changes in oxidative stress are observed, especially during the transition period [ 5 , 14 , 15 , 17 ]. In fact, increasing the amount of glutamine in the transition period has effective effects on increasing antioxidant capacity and can lead to increased dry matter intake [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is established a dynamic relationship between oxidant and antioxidant status during estrus cycle in healthy cows, and it is speculated that oxidative stress has a crucial physiological role in facilitating the ovulation process in estrus synchronized dairy cows [ 4 ]. In addition, a relationship between the physiological status associated with parturition and the breakdown in overall antioxidant potential is established both in humans and dairy cow [ 5 , 6 ]. The impact of oxidative stress during the transition period may be a major underlying factor of inflammatory and immune dysfunction in dairy cattle as supported by in vivo and in vitro studies [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Reproduction performance and blood biochemical parameters in dairy cows: Relationship with oxidative stress status

et al. 2018

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Background and Aim:During the last decades, reproduction performances declined dramatically worldwide, but little is known concerning the involvement of oxidative stress as a causative factor. Oxidative stress may act at different levels, with negative impacts on cell membrane integrity and other active molecules with potential subsequent effects on reproduction. The aim of the current study was to investigate the oxidative stress status in cows according to their reproductive performances.Materials and Methods:Peripheral blood concentration of two oxidative stress biomarkers, glutathione S-transferase (GST) and malondialdehyde (MDA), and other biochemical parameters (glucose, total lipids, cholesterol, triglycerides, albumin, total proteins, calcium, urea, creatinine, direct bilirubin, alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase) were determined in 40 healthy cows. Body condition score (BCS), calving to first service interval (FSI), calving to conception interval (CCI), and the number of service per conception (SPC) were simultaneously recorded for each cow.Results:Concerning FSI, three groups were established: Group 1 (from 44 to 60 days), Group 2 (from 60 to 70 days), and Group 3 (from 70 to 80 days). For CCI, two groups were considered: Group 1 (<110 days) and Group 2 (>110 days). MDA showed significant high values only in cows with the lowest BCS (1.5) compared to cows with BCS note of 2.5 and 3.5. No significant difference was observed in cows oxidative stress status (MDA and GST) according to reproductive performances (FSI, CCI, and SPC) in all studied groups.Conclusion:The results revealed relatively altered oxidative stress status in cows with abnormal reproductive performances; however, no significant difference was recorded whatever the considered reproductive parameter.

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MDA and GSH-Px activity in transition dairy cows under seasonal variations and their relationship with reproductive performance

Cited by 39 publications

References 39 publications

Relationship between body condition score, blood metabolites and oxidative stress in transition period and reproductive performance of dairy cows

Relationship between body condition score, blood metabolites and oxidative stress in transition period and reproductive performance of dairy cows

Prepartum Fat Mobilization in Dairy Cows with Equal Body Condition and Its Impact on Health, Behavior, Milk Production and Fertility during Lactation

Reproduction performance and blood biochemical parameters in dairy cows: Relationship with oxidative stress status

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