Impact of quercetin and fish oil encapsulation on bilayer membrane and oxidation stability of liposomes

Frenzel, Monika; Steffen‐Heins, Anja

doi:10.1016/j.foodchem.2015.03.121

Cited by 63 publications

(37 citation statements)

References 31 publications

(40 reference statements)

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“…However, at an alkaline pH, liposomes are easily swollen and disintegrated, allowing release of core materials . Furthermore, having resemblance to biological membranes, liposomes may be able to cross biological barriers with most of the entrapped materials unaltered . Thus liposomes are highly utilized as oral delivery systems.…”

Section: Resultsmentioning

confidence: 99%

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Enhanced bioactivity and efficient delivery of quercetin through nanoliposomal encapsulation using rice bran phospholipids

et al. 2018

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BACKGROUND Quercetin is a phenolic compound occurring in many food plants and agricultural crops. It is reported to possess various health‐promoting properties. However, the poor bioavailability of quercetin, due to its low aqueous solubility and its degradation during digestion, limits its nutraceutical applications. This study aimed to encapsulate quercetin in nanoliposomes using rice‐bran phospholipids for its efficient delivery and controlled release, the protection of its structural stability, and enhancement of its bioactivity. RESULTS Nanoliposomal encapsulation of quercetin by thin film‐sonication method yielded spherical nanoparticles (157.33 ± 23.78 nm) with high encapsulation efficiency (84.92 ± 0.78%). Storage stability studies showed that nanoliposomal quercetin was stable at 4 °C and 27 °C for 6 and 5 months, respectively, as indicated by unchanged antioxidant activity and quercetin retention. Nanoliposomal quercetin showed a slow, limited release pattern in simulated gastric fluid (SGF), and an initial burst release followed by a slow constant releasing pattern in simulated intestinal fluid (SIF). A 1004‐fold increase in 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical‐scavenging activity was observed in quercetin nanoliposomes (SC50 = 4.04 ± 0.01 ppm) compared to non‐encapsulated quercetin (SC50 = 4053.03 ± 5.61 ppm). Similarly, the anti‐angiogenic activity of quercetin, as evaluated by duck embryo chorioallantoic membrane (CAM) assay, was enhanced twofold to fivefold by nanoliposomal encapsulation. CONCLUSION This study showed that nanoliposomal encapsulation in rice‐bran phospholipids enhanced the radical‐scavenging and anti‐angiogenic activities of quercetin. Furthermore, this study demonstrated that nanoliposomes can serve as efficient oral delivery system for quercetin. © 2018 Society of Chemical Industry

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Section: Resultsmentioning

confidence: 99%

“…Furthermore, nanoliposomal encapsulation of a bioactive substance protects it from the surrounding environment, improving its storage life and stability. It also prevents it from interacting with other molecules, masks undesirable properties such as odor and taste, and facilitates its delivery and release in the target sites of action …”

Section: Introductionmentioning

confidence: 99%

Enhanced bioactivity and efficient delivery of quercetin through nanoliposomal encapsulation using rice bran phospholipids

et al. 2018

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“…Encapsulation is widely utilized in functional food industry to encapsulate lipophilic compounds in natural products such as plant‐based seed oils. Usually, these ingredients are incorporated into lipid‐based carrier systems such as single and multilayer emulsions, solid‐lipid nanoparticles, micelles, or liposomes . Encapsulation is the enclosing of substances within an inert material to protect sensitive compounds from degradation, masking of unpleasant tastes, reduction of losses due to evaporation, prevention of binding or interaction with other food matrix components, as well as controlled release facilitation under desired conditions .…”

Section: Recent Developments In Formulation Of Psomentioning

confidence: 99%

“…Usually, these ingredients are incorporated into lipid-based carrier systems such as single and multilayer emulsions, solid-lipid nanoparticles, micelles, or liposomes. [81] Encapsulation is the enclosing of substances within an inert material to protect sensitive compounds from degradation, masking of unpleasant tastes, reduction of losses due to evaporation, prevention of binding or interaction with other food matrix components, as well as controlled release facilitation under desired conditions. [82] Additionally, encapsulation is expected to maintain the attributes of nutraceutical and functional products during processing and storage while enhancing the stability, bioavailability and bioactivity of the encapsulated compounds.…”

Section: Encapsulationmentioning

confidence: 99%

“…It has been used to encapsulate bioactive components, such as carotenoids, phytosterols, polyunsaturated fatty acids, astaxanthin, and lipophilic vitamins. [30,110] Cao et al [30] modified PuA with glycerol to obtain the amphiphilic nanodispersed monoglycerides of PuA after hydration with remarkable oxidative [26,27,81,105,109] , B, [55,67,80,98] C [30] .…”

Section: Formulation Of Pua and Other Compounds With Pso As Oil Phasementioning

confidence: 99%

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Formulation of Pomegranate Seed Oil: A Promising Approach of Improving Stability and Health‐Promoting Properties

Adu‐Frimpong

Omari‐Siaw

Mukhtar

et al. 2018

Euro J Lipid Sci & Tech

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Emerging evidence has suggested that nutraceutical ingredients like pomegranate seed oil (PSO) possesses health‐promoting effects in cell and animal models. However, these health benefits (anticancer, antioxidant, anti‐inflammatory, anti‐diabetic, and so on) are limited by low physicochemical stability, slow intestinal absorption, and rapid metabolism of PSO. In order to overcome these drawbacks, some carriers viz., nanoemulsion, encapsulation, and nanoparticles are developed recently. This paper assesses the chemical compositions and physicochemical properties of PSO, as well as biological activities and possible mechanisms. It also discusses the formulation of PSO for improved stability and health‐promoting activities. Practical Applications: This review highlights the prospects of PSO formulation. The relevance of this study is that the stability and biological properties of PSO could be enhanced through nanocarriers. A formulated PSO has a potential use in nutraceutical, functional foods, pharmaceutical and cosmetic industries. PSO, a source of various nutrients and antioxidants with immense benefits to human health is incorporated into nanocarriers such as microencapsulation, nanoemulsion and nanoparticle. This improved the health‐promoting benefits of the oil.

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Co‐axial electrospinning of liposomal propolis loaded gelatin‐zein fibers as a potential wound healing material

Karakas,

Ustundag,

Sahin

et al. 2023

J of Applied Polymer Sci

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In this study, propolis extract (PE) was first encapsulated in different liposomal formulations (65–370 nm) with high encapsulation efficiency (68%–93%). The liposomal PE was further embedded in a food‐grade gelatin‐zein core/shell fiber by using the co‐axial electrospinning method. Transmission electron and confocal laser scanning microscopy verified the structure of liposomes and their homogeneous dispersion in fibers. Scanning electron microscopy (SEM) images confirmed the smooth morphologies of core/shell liposomal fibers. The loading of PE in liposomal fibers improved both thermal (differential scanning calorimetry) and textural (elongation at break and tensile strength) properties, and the fibers loaded with more PE provided higher mucoadhesiveness. The PE‐loaded fiber showed higher antimicrobial activity against Staphylococcus aureus. The incorporation of liposomal PE in fiber enhanced the viability of human skin fibroblast (HFF‐1) cells. The adhesion of HFF‐1 cells on fiber was demonstrated by SEM, thus PE‐loaded liposomal fiber could provide an efficient platform for cell growth. The findings of this study proposed that propolis‐loaded liposomal hybrid fibers produced by the co‐axial method can be used as a potential wound healing material.

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Impact of quercetin and fish oil encapsulation on bilayer membrane and oxidation stability of liposomes

Cited by 63 publications

References 31 publications

Enhanced bioactivity and efficient delivery of quercetin through nanoliposomal encapsulation using rice bran phospholipids

Enhanced bioactivity and efficient delivery of quercetin through nanoliposomal encapsulation using rice bran phospholipids

Formulation of Pomegranate Seed Oil: A Promising Approach of Improving Stability and Health‐Promoting Properties

Co‐axial electrospinning of liposomal propolis loaded gelatin‐zein fibers as a potential wound healing material

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