Impact of presence of excipients in drug analysis in fed-state gastric biorelevant media

Baxevanis, Fotios; Kuiper, Jesse; Fotaki, Nikoletta

doi:10.1016/j.ejpb.2018.08.004

Cited by 2 publications

(3 citation statements)

References 64 publications

(59 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Improving solubility and membrane permeability could lead to enhance of oral bioavailability [4]. Drug solubility could be increased by a dry or wet process, for example, indissolvable nifedipine co-grinding with a carrier such as polyvinyl pyrrolidone or microcrystalline cellulose by dry method could enhance the solubility [5][6][7]. However, this method could not be used to produce Nano-level preparation.…”

Section: -(2-mentioning

confidence: 99%

See 1 more Smart Citation

A Liposomal Formulation for Improving Solubility and Oral Bioavailability of Nifedipine

et al. 2020

Molecules

View full text Add to dashboard Cite

Proliposomes were used to improve the solubility and oral bioavailability of nifedipine. Nifedipine proliposomes were prepared by methanol injection-spray drying method. The response surface method was used to optimize formulation to enhance the encapsulation efficiency (EE%) of nifedipine. The particle size of nifedipine proliposomes after rehydration was 114 nm. Surface morphology of nifedipine proliposomes was observed by a scanning electron microscope (SEM) and interaction of formulation ingredients was assessed by differential scanning calorimetry (DSC). The solubility of nifedipine is improved 24.8 times after forming proliposomes. In vitro release experiment, nifedipine proliposomes had a control release effect, especially in simulated gastric fluid. In vivo, nifedipine proliposomes significantly improved the bioavailability of nifedipine. The area under the concentration-time curve (AUC0–∞) of nifedipine proliposomes was about 10 times than nifedipine after oral administration. The elimination half-life (T1/2β) of nifedipine was increased from 1.6 h to 6.6 h. In conclusion, proliposomes was a promising system to deliver nifedipine through oral route and warranted further investigation.

show abstract

Section: -(2-mentioning

confidence: 99%

“…However, it is a challenge to remove residual organic solvent. Therefore, novel formulations were also developed to improve therapeutic effects of nifedipine, including microparticles [9], inclusion complexes [10], freeze-dried lipid nanoparticles [7], and gelatin microcapsules [11,12].…”

Section: -(2-mentioning

confidence: 99%

A Liposomal Formulation for Improving Solubility and Oral Bioavailability of Nifedipine

et al. 2020

Molecules

View full text Add to dashboard Cite

show abstract

“…(1). Recently, the issue of cow milk as a medium for testing drug solubility and for evaluating product dissolution has been raised as a point of interest for several reasons (2)(3)(4)(5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Factors Influencing the Selection of Medium for Evaluating Drug Solubility and Dissolution in Bovine Milk

Martinez,

Longstaff,

Fellner

et al. 2023

Dissolution Technol.

View full text Add to dashboard Cite

Human drug delivery: Cow milk is a potential vehicle for delivering drugs to pediatric and geriatric patients (4-6). Therefore, the issue of drug solubility in milk, or its adsorption to milk proteins and fats, is relevant for both human and animal health. This led the USP to initiate an effort to define the composition of milk in normal and mastitic cattle and the variability that may exist across cow nutritional and health status.• Milk has been suggested as a component of fedstate simulated gastric fluids (SGFs) (7).

show abstract

Impact of presence of excipients in drug analysis in fed-state gastric biorelevant media

Cited by 2 publications

References 64 publications

A Liposomal Formulation for Improving Solubility and Oral Bioavailability of Nifedipine

A Liposomal Formulation for Improving Solubility and Oral Bioavailability of Nifedipine

Factors Influencing the Selection of Medium for Evaluating Drug Solubility and Dissolution in Bovine Milk

Contact Info

Product

Resources

About